ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

Название протокола
Клинические исследование Cardiovascular Risk: Ziltivekimab, Placebo (ziltivekimab) - Реестр клинических исследований
Платное
Нет
Дата начала и окончания КИ
2022-02-06 - 2022-02-06
Спонсоры

Ведущий спонсор: Novo Nordisk A/S

Источник Novo Nordisk A/S
Краткое содержание

This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe. Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits. Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.

Общий статус Recruiting
Дата начала 2021-08-30
Дата завершения 2025-10-15
Дата первичного завершения 2025-09-24
Фаза Phase 3
Тип исследования Interventional
Первичный результат
Мера Временное ограничение
Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: Cardiovascular (CV ) death (Based on EAC-confirmed events; including undetermined cause of death) From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of 3-point MACE, a composite endpoint consisting of: non-fatal myocardial infarction(MI) ( Based on EAC-confirmed events; including undetermined cause of death; acute MI only) From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of 3-point MACE, a composite endpoint consisting of: non-fatal stroke (Based on EAC-confirmed events; including ischaemic, haemorrhagic and undetermined stroke) From randomisation (month 0) to end-of-study (up to 48 months)
Вторичный результат
Мера Временное ограничение
Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death (Based on EAC-confirmed events; including undetermined cause of death From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: non-fatal MI (Based on EAC-confirmed events; acute MI only) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: non-fatal stroke (Based on EAC-confirmed events; including ischaemic, haemorrhagic and undetermined stroke) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Number of hospitalisations for heart failure (Based on EAC-confirmed events) or urgent heart failure visit (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to occurrence of all-cause mortality (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of:onset of persistent greater than or equal to 40% reduction in eGFR (CKD-EPI) compared with baseline From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of kidney failure defined as:death from kidney failure From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of:kidney failure defined as onset of persistente eGFR below 15 mL/min/1.73 m^2 (CKD-EPI) From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of: initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of each of the individual components (Based on EAC-confirmed events) of the expanded MACE endpoint and the kidney composite endpoint From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of MIs (acute MI only) (fatal and non-fatal) (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of stroke (including ischaemic, haemorrhagic and undetermined stroke) (fatal and non-fatal)(Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:all-cause mortality (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:non-fatal MI (Based on EAC-confirmed events; acute MI only) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:non-fatal stroke (Based on EAC-confirmed events,including ischaemic, haemorrhagic and undetermined stroke) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:CV death (Based on EAC-confirmed events; including undetermined cause of death) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:onset of persistent greater than or equal to 40% reduction in eGFR (CKD-EPI) compared with baseline From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as:death from kidney failure From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as onset of persistent eGFR below 15 mL/min/1.73 m^2 (CKD-EPI) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as:initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation) (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of coronary revascularisation From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in UACR (urinary albumin-to-creatinine ratio ) From randomisation (month 0) to 2 years (24 months)
Change in eGFR (estimated glomerular filtration rate) (chronic kidney disease - epidemiology collaboration (CKD-EPI)) From randomisation (month 0) to 2 years (24 months)
Annual rate of change in eGFR (CKD-EPI) (total eGFR slope) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in high-sensitivity C-reactive protein (hs-CRP) From randomisation (month 0) to 2 years (24 months
Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP) From randomisation (month 0) to 2 years (24 months)
Change in left ventricular ejection fraction (LVEF) From randomisation (month 0) to 2 years (24 months)
Number of events of atrial fibrillation From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Number of hospitalisations with infection as primary cause (Based on EAC-confirmed events) or death due to infection (Based on EAC-confirmed events) From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in Short Form 36 (SF-36) Physical Component Score (PCS) From randomisation (month 0) to 2 years (24 months)
Регистрация 6200
Состояние
  • Cardiovascular Risk
  • Chronic Kidney Disease
  • Inflammation
Вмешательство

Тип вмешательства: Drug

Название вмешательства: Ziltivekimab

Описание: Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care

Этикетка Arm Group: ziltivekimab 15 mg

Тип вмешательства: Drug

Название вмешательства: Placebo (ziltivekimab)

Описание: Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care

Этикетка Arm Group: Placebo (ziltivekimab)

Приемлемость

Критерии:

Inclusion Criteria: - Estimated glomerular filtration rate (eGFR) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation) - Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 mg/L at screening (visit 1) - Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following within the last 5 years from screening: a) Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound. c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis). Exclusion Criteria: - Clinical evidence of, or suspicion of, active infection at the discretion of the investigator. - Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2). - Planned coronary, carotid or peripheral artery revascularisation known on the day of screening (visit 1). - Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).

Пол:

All

Минимальный возраст:

18 Years

Максимальный возраст:

N/A

Здоровые волонтеры:

No

Общий Официальный
Фамилия Роль Присоединение
Clinical Transparency (dept. 1452) Study Director Novo Nordisk A/S
Общий контакт

Фамилия: Novo Nordisk

Телефон: (+1) 866-867-7178

Расположение
Объект: Положение дел:
Novo Nordisk Investigational Site | Birmingham, Alabama, 35294, United States Recruiting
Novo Nordisk Investigational Site | Montgomery, Alabama, 36106, United States Recruiting
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Novo Nordisk Investigational Site | Lancaster, California, 93534, United States Not yet recruiting
Novo Nordisk Investigational Site | Los Alamitos, California, 90720, United States Recruiting
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Novo Nordisk Investigational Site | Northridge, California, 91325, United States Recruiting
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Novo Nordisk Investigational Site | San Dimas, California, 91773, United States Recruiting
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Novo Nordisk Investigational Site | Boca Raton, Florida, 33434, United States Recruiting
Novo Nordisk Investigational Site | Boynton Beach, Florida, 33437, United States Recruiting
Novo Nordisk Investigational Site | Clearwater, Florida, 33756, United States Recruiting
Novo Nordisk Investigational Site | Fleming Island, Florida, 32003, United States Recruiting
Novo Nordisk Investigational Site | Hollywood, Florida, 33021, United States Recruiting
Novo Nordisk Investigational Site | Jacksonville, Florida, 32204, United States Not yet recruiting
Novo Nordisk Investigational Site | Miami Lakes, Florida, 33014, United States Recruiting
Novo Nordisk Investigational Site | Miami, Florida, 33126, United States Not yet recruiting
Novo Nordisk Investigational Site | Miami, Florida, 33130, United States Recruiting
Novo Nordisk Investigational Site | Miami, Florida, 33155, United States Not yet recruiting
Novo Nordisk Investigational Site | New Port Richey, Florida, 34652, United States Not yet recruiting
Novo Nordisk Investigational Site | Palm Harbor, Florida, 34684, United States Recruiting
Novo Nordisk Investigational Site | Pembroke Pines, Florida, 33024, United States Not yet recruiting
Novo Nordisk Investigational Site | Pembroke Pines, Florida, 33027, United States Recruiting
Novo Nordisk Investigational Site | Port Charlotte, Florida, 33952, United States Recruiting
Novo Nordisk Investigational Site | Port Charlotte, Florida, 33952, United States Not yet recruiting
Novo Nordisk Investigational Site | Saint Augustine, Florida, 32080, United States Recruiting
Novo Nordisk Investigational Site | Saint Augustine, Florida, 32086, United States Recruiting
Novo Nordisk Investigational Site | Winter Haven, Florida, 33880, United States Recruiting
Novo Nordisk Investigational Site | Augusta, Georgia, 30904, United States Recruiting
Novo Nordisk Investigational Site | Conyers, Georgia, 30094, United States Recruiting
Novo Nordisk Investigational Site | Johns Creek, Georgia, 30024, United States Not yet recruiting
Novo Nordisk Investigational Site | Roswell, Georgia, 30076, United States Not yet recruiting
Novo Nordisk Investigational Site | Savannah, Georgia, 31406, United States Not yet recruiting
Novo Nordisk Investigational Site | Nampa, Idaho, 83686-6011, United States Not yet recruiting
Novo Nordisk Investigational Site | Arlington Heights, Illinois, 60005, United States Not yet recruiting
Novo Nordisk Investigational Site | Gurnee, Illinois, 60031, United States Recruiting
Novo Nordisk Investigational Site | Hazel Crest, Illinois, 60429, United States Not yet recruiting
Novo Nordisk Investigational Site | Skokie, Illinois, 60077, United States Recruiting
Novo Nordisk Investigational Site | Springfield, Illinois, 62711, United States Recruiting
Novo Nordisk Investigational Site | Wauconda, Illinois, 60084, United States Not yet recruiting
Novo Nordisk Investigational Site | Evansville, Indiana, 47714, United States Not yet recruiting
Novo Nordisk Investigational Site | Valparaiso, Indiana, 46383, United States Not yet recruiting
Novo Nordisk Investigational Site | Overland Park, Kansas, 66211, United States Recruiting
Novo Nordisk Investigational Site | Topeka, Kansas, 66606, United States Not yet recruiting
Novo Nordisk Investigational Site | Lexington, Kentucky, 40503, United States Not yet recruiting
Novo Nordisk Investigational Site | Louisville, Kentucky, 40205, United States Not yet recruiting
Novo Nordisk Investigational Site | Bossier City, Louisiana, 71111, United States Not yet recruiting
Novo Nordisk Investigational Site | Monroe, Louisiana, 71201, United States Recruiting
Novo Nordisk Investigational Site | Slidell, Louisiana, 70458, United States Recruiting
Novo Nordisk Investigational Site | West Monroe, Louisiana, 71201, United States Recruiting
Novo Nordisk Investigational Site | Annapolis, Maryland, 21401, United States Not yet recruiting
Novo Nordisk Investigational Site | Bethesda, Maryland, 20814, United States Not yet recruiting
Novo Nordisk Investigational Site | Camp Springs, Maryland, 20746, United States Not yet recruiting
Novo Nordisk Investigational Site | Boston, Massachusetts, 02115-5804, United States Not yet recruiting
Novo Nordisk Investigational Site | Haverhill, Massachusetts, 01830, United States Not yet recruiting
Novo Nordisk Investigational Site | Detroit, Michigan, 48202, United States Recruiting
Novo Nordisk Investigational Site | Flint, Michigan, 48532, United States Recruiting
Novo Nordisk Investigational Site | Grand Rapids, Michigan, 49546, United States Not yet recruiting
Novo Nordisk Investigational Site | Minneapolis, Minnesota, 55407, United States Not yet recruiting
Novo Nordisk Investigational Site | Kansas City, Missouri, 64111, United States Recruiting
Novo Nordisk Investigational Site | Saint Louis, Missouri, 63128, United States Not yet recruiting
Novo Nordisk Investigational Site | Saint Louis, Missouri, 63136, United States Recruiting
Novo Nordisk Investigational Site | Lincoln, Nebraska, 68526, United States Recruiting
Novo Nordisk Investigational Site | Omaha, Nebraska, 68105, United States Not yet recruiting
Novo Nordisk Investigational Site | Omaha, Nebraska, 68114, United States Not yet recruiting
Novo Nordisk Investigational Site | Omaha, Nebraska, 68198-3020, United States Not yet recruiting
Novo Nordisk Investigational Site | Las Vegas, Nevada, 89128, United States Recruiting
Novo Nordisk Investigational Site | Bridgewater, New Jersey, 08807-3064, United States Not yet recruiting
Novo Nordisk Investigational Site | Northport, New York, 11768, United States Not yet recruiting
Novo Nordisk Investigational Site | Ridgewood, New York, 11385, United States Not yet recruiting
Novo Nordisk Investigational Site | Saratoga Springs, New York, 12866, United States Not yet recruiting
Novo Nordisk Investigational Site | West Seneca, New York, 14224, United States Recruiting
Novo Nordisk Investigational Site | Westfield, New York, 14787, United States Not yet recruiting
Novo Nordisk Investigational Site | Asheville, North Carolina, 28801, United States Recruiting
Novo Nordisk Investigational Site | Burlington, North Carolina, 27215, United States Not yet recruiting
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Novo Nordisk Investigational Site | Charlotte, North Carolina, 28207, United States Not yet recruiting
Novo Nordisk Investigational Site | Greensboro, North Carolina, 27408, United States Recruiting
Novo Nordisk Investigational Site | Greenville, North Carolina, 27834, United States Recruiting
Novo Nordisk Investigational Site | Morehead City, North Carolina, 28557-4346, United States Recruiting
Novo Nordisk Investigational Site | Fargo, North Dakota, 58104, United States Recruiting
Novo Nordisk Investigational Site | Cleveland, Ohio, 44106, United States Not yet recruiting
Novo Nordisk Investigational Site | Maumee, Ohio, 43537, United States Not yet recruiting
Novo Nordisk Investigational Site | Bethlehem, Pennsylvania, 18017, United States Not yet recruiting
Novo Nordisk Investigational Site | Philadelphia, Pennsylvania, 19114, United States Recruiting
Novo Nordisk Investigational Site | Philadelphia, Pennsylvania, 19144, United States Not yet recruiting
Novo Nordisk Investigational Site | Lincoln, Rhode Island, 02865, United States Not yet recruiting
Novo Nordisk Investigational Site | Fort Mill, South Carolina, 29707, United States Recruiting
Novo Nordisk Investigational Site | Greenville, South Carolina, 29615, United States Not yet recruiting
Novo Nordisk Investigational Site | Myrtle Beach, South Carolina, 29588, United States Suspended
Novo Nordisk Investigational Site | Spartanburg, South Carolina, 29303, United States Not yet recruiting
Novo Nordisk Investigational Site | Chattanooga, Tennessee, 37411, United States Recruiting
Novo Nordisk Investigational Site | Greeneville, Tennessee, 37745, United States Recruiting
Novo Nordisk Investigational Site | Knoxville, Tennessee, 37934, United States Recruiting
Novo Nordisk Investigational Site | Memphis, Tennessee, 38119, United States Not yet recruiting
Novo Nordisk Investigational Site | Arlington, Texas, 76012-4637, United States Not yet recruiting
Novo Nordisk Investigational Site | Corpus Christi, Texas, 78414, United States Recruiting
Novo Nordisk Investigational Site | Dallas, Texas, 75208, United States Recruiting
Novo Nordisk Investigational Site | Dallas, Texas, 75230, United States Not yet recruiting
Novo Nordisk Investigational Site | Dallas, Texas, 75235, United States Not yet recruiting
Novo Nordisk Investigational Site | Edinburg, Texas, 78539, United States Not yet recruiting
Novo Nordisk Investigational Site | El Paso, Texas, 79935, United States Recruiting
Novo Nordisk Investigational Site | Forney, Texas, 75126, United States Recruiting
Novo Nordisk Investigational Site | Fort Worth, Texas, 76132, United States Not yet recruiting
Novo Nordisk Investigational Site | Fort Worth, Texas, 76133, United States Not yet recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77024, United States Not yet recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77043, United States Recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77054, United States Recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77079, United States Not yet recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77084, United States Not yet recruiting
Novo Nordisk Investigational Site | Houston, Texas, 77090, United States Not yet recruiting
Novo Nordisk Investigational Site | Live Oak, Texas, 78233, United States Recruiting
Novo Nordisk Investigational Site | Longview, Texas, 75605, United States Recruiting
Novo Nordisk Investigational Site | Lufkin, Texas, 75904, United States Recruiting
Novo Nordisk Investigational Site | San Antonio, Texas, 78212, United States Recruiting
Novo Nordisk Investigational Site | San Antonio, Texas, 78215, United States Recruiting
Novo Nordisk Investigational Site | San Antonio, Texas, 78224, United States Not yet recruiting
Novo Nordisk Investigational Site | San Antonio, Texas, 78230, United States Recruiting
Novo Nordisk Investigational Site | San Marcos, Texas, 78666, United States Not yet recruiting
Novo Nordisk Investigational Site | Sugar Land, Texas, 77478, United States Recruiting
Novo Nordisk Investigational Site | Waco, Texas, 76708, United States Not yet recruiting
Novo Nordisk Investigational Site | Webster, Texas, 77598, United States Not yet recruiting
Novo Nordisk Investigational Site | Forest, Virginia, 24551, United States Not yet recruiting
Novo Nordisk Investigational Site | Norfolk, Virginia, 23510-2015, United States Recruiting
Novo Nordisk Investigational Site | Salem, Virginia, 24153-6404, United States Recruiting
Novo Nordisk Investigational Site | Winchester, Virginia, 22601-3834, United States Recruiting
Novo Nordisk Investigational Site | Wausau, Wisconsin, 54401, United States Recruiting
Novo Nordisk Investigational Site | Buenos Aires, B6000BHA, Argentina Not yet recruiting
Novo Nordisk Investigational Site | Caba, C1213, Argentina Not yet recruiting
Novo Nordisk Investigational Site | Caba, C1428ART, Argentina Not yet recruiting
Novo Nordisk Investigational Site | Caba, C1440CFD, Argentina Recruiting
Novo Nordisk Investigational Site | Ciudad Autónoma de Buenos Aire, 1425, Argentina Recruiting
Novo Nordisk Investigational Site | Mar del Plata, B7600GNY, Argentina Not yet recruiting
Novo Nordisk Investigational Site | Quilmes - Buenos Aires, B1878DVB, Argentina Not yet recruiting
Novo Nordisk Investigational Site | San Nicolás, B2900, Argentina Not yet recruiting
Novo Nordisk Investigational Site | Garran, Australian Capital Territory, 2605, Australia Recruiting
Novo Nordisk Investigational Site | Gosford, New South Wales, 2250, Australia Recruiting
Novo Nordisk Investigational Site | Milton, Queensland, 4064, Australia Recruiting
Novo Nordisk Investigational Site | Adelaide, South Australia, 5000, Australia Not yet recruiting
Novo Nordisk Investigational Site | Clayton, Victoria, 3168, Australia Not yet recruiting
Novo Nordisk Investigational Site | Fitzroy, Victoria, 3065, Australia Not yet recruiting
Novo Nordisk Investigational Site | Geelong, Victoria, 3220, Australia Not yet recruiting
Novo Nordisk Investigational Site | Joondalup, Western Australia, 6027, Australia Recruiting
Novo Nordisk Investigational Site | Aalst, 9300, Belgium Not yet recruiting
Novo Nordisk Investigational Site | Brasschaat, 2930, Belgium Not yet recruiting
Novo Nordisk Investigational Site | Brugge, 8000, Belgium Recruiting
Novo Nordisk Investigational Site | Genk, 3600, Belgium Recruiting
Novo Nordisk Investigational Site | Kortrijk, 8500, Belgium Recruiting
Novo Nordisk Investigational Site | Liège, 4000, Belgium Not yet recruiting
Novo Nordisk Investigational Site | Mechelen, 2800, Belgium Not yet recruiting
Novo Nordisk Investigational Site | Curitiba, Parana, 80440-020, Brazil Not yet recruiting
Novo Nordisk Investigational Site | Pleven, 5800, Bulgaria Recruiting
Novo Nordisk Investigational Site | Plovdiv, 4002, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Sofia, 1309, Bulgaria Recruiting
Novo Nordisk Investigational Site | Sofia, 1407, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Sofia, 1431, Bulgaria Recruiting
Novo Nordisk Investigational Site | Sofia, 1431, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Sofia, 1527, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Sofia, 1750, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Sofia, 1750, Bulgaria Recruiting
Novo Nordisk Investigational Site | Varna, 9010, Bulgaria Not yet recruiting
Novo Nordisk Investigational Site | Calgary, Alberta, T2H 2G4, Canada Recruiting
Novo Nordisk Investigational Site | Calgary, Alberta, T2V 4J2, Canada Recruiting
Novo Nordisk Investigational Site | Vancouver, British Columbia, V5Y 3W2, Canada Recruiting
Novo Nordisk Investigational Site | Halifax, Nova Scotia, B3H 2Y9, Canada Not yet recruiting
Novo Nordisk Investigational Site | Barrie, Ontario, L4N 7L3, Canada Recruiting
Novo Nordisk Investigational Site | Brampton, Ontario, L6S 0C6, Canada Recruiting
Novo Nordisk Investigational Site | Concord, Ontario, L4K 4M2, Canada Recruiting
Novo Nordisk Investigational Site | Etobicoke, Ontario, M9R 4E1, Canada Recruiting
Novo Nordisk Investigational Site | Hamilton, Ontario, L8M 1K7, Canada Recruiting
Novo Nordisk Investigational Site | Nepean, Ontario, K2J 0V2, Canada Recruiting
Novo Nordisk Investigational Site | North York, Ontario, M6B 3H7, Canada Recruiting
Novo Nordisk Investigational Site | Oakville, Ontario, L6K 3W7, Canada Not yet recruiting
Novo Nordisk Investigational Site | Oakville, Ontario, L6M 1M1, Canada Recruiting
Novo Nordisk Investigational Site | Peterborough, Ontario, K9J 0B2, Canada Not yet recruiting
Novo Nordisk Investigational Site | Scarborough, Ontario, M1B 4Z8, Canada Not yet recruiting
Novo Nordisk Investigational Site | Toronto, Ontario, M4G 3E8, Canada Recruiting
Novo Nordisk Investigational Site | Toronto, Ontario, M6G 1M2, Canada Not yet recruiting
Novo Nordisk Investigational Site | Waterloo, Ontario, N2T 0C1, Canada Not yet recruiting
Novo Nordisk Investigational Site | Brossard, Quebec, J4Z-2K9, Canada Recruiting
Novo Nordisk Investigational Site | Laval, Quebec, H7T 2P5, Canada Recruiting
Novo Nordisk Investigational Site | Quebec, G1G 3Y8, Canada Not yet recruiting
Novo Nordisk Investigational Site | Beijing, Beijing, 100853, China Not yet recruiting
Novo Nordisk Investigational Site | Aarhus N, 8200, Denmark Not yet recruiting
Novo Nordisk Investigational Site | Herning, 7400, Denmark Recruiting
Novo Nordisk Investigational Site | Hvidovre, 2650, Denmark Recruiting
Novo Nordisk Investigational Site | Svendborg, 5700, Denmark Recruiting
Novo Nordisk Investigational Site | Aachen, 52074, Germany Not yet recruiting
Novo Nordisk Investigational Site | Bad Homburg, 61348, Germany Not yet recruiting
Novo Nordisk Investigational Site | Dresden, 01277, Germany Suspended
Novo Nordisk Investigational Site | Düsseldorf, 40210, Germany Not yet recruiting
Novo Nordisk Investigational Site | Elsterwerda, 04910, Germany Not yet recruiting
Novo Nordisk Investigational Site | Essen, 45136, Germany Recruiting
Novo Nordisk Investigational Site | Falkensee, 14612, Germany Not yet recruiting
Novo Nordisk Investigational Site | Lübeck, 23562, Germany Not yet recruiting
Novo Nordisk Investigational Site | Oldenburg I. Holst, 23758, Germany Recruiting
Novo Nordisk Investigational Site | Witten, 58455, Germany Suspended
Novo Nordisk Investigational Site | Athens, 11527, Greece Not yet recruiting
Novo Nordisk Investigational Site | Athens, GR-11527, Greece Not yet recruiting
Novo Nordisk Investigational Site | Athens, GR-11528, Greece Recruiting
Novo Nordisk Investigational Site | Athens, GR-14233, Greece Recruiting
Novo Nordisk Investigational Site | Athens, GR-15123, Greece Recruiting
Novo Nordisk Investigational Site | Chios, GR82100, Greece Recruiting
Novo Nordisk Investigational Site | Haidari-Athens, GR-12462, Greece Recruiting
Novo Nordisk Investigational Site | Ioannina, 45500, Greece Not yet recruiting
Novo Nordisk Investigational Site | Kifissia, GR-14561, Greece Recruiting
Novo Nordisk Investigational Site | Lamia, GR35100, Greece Not yet recruiting
Novo Nordisk Investigational Site | Larissa, GR-41110, Greece Recruiting
Novo Nordisk Investigational Site | Patra, GR-26504, Greece Recruiting
Novo Nordisk Investigational Site | Thessaloniki, GR-57010, Greece Not yet recruiting
Novo Nordisk Investigational Site | Vijayawada, Andhra Pradesh, 520002, India Recruiting
Novo Nordisk Investigational Site | Mangalore, Karnataka, 575002, India Recruiting
Novo Nordisk Investigational Site | Manipal, Karnataka, 576104, India Recruiting
Novo Nordisk Investigational Site | Nagpur, Maharashtra, 440003, India Recruiting
Novo Nordisk Investigational Site | Hyderabad, Telengana, 500012, India Recruiting
Novo Nordisk Investigational Site | Belgaum, 590010, India Recruiting
Novo Nordisk Investigational Site | Holon, 58100, Israel Recruiting
Novo Nordisk Investigational Site | Jerusalem, 91120, Israel Recruiting
Novo Nordisk Investigational Site | Rehovot, 7661041, Israel Recruiting
Novo Nordisk Investigational Site | Tel Aviv, 6423906, Israel Recruiting
Novo Nordisk Investigational Site | Tel Hashomer, 5265601, Israel Recruiting
Novo Nordisk Investigational Site | Catanzaro, 88100, Italy Not yet recruiting
Novo Nordisk Investigational Site | Milano, 20138, Italy Not yet recruiting
Novo Nordisk Investigational Site | Milan, 20132, Italy Not yet recruiting
Novo Nordisk Investigational Site | Montichiari, 25018, Italy Not yet recruiting
Novo Nordisk Investigational Site | Rome, 00189, Italy Recruiting
Novo Nordisk Investigational Site | Verona, 37126, Italy Recruiting
Novo Nordisk Investigational Site | Bunkyo-ku, Tokyo, 113-8655, Japan Not yet recruiting
Novo Nordisk Investigational Site | Fukushima, 963-8851, Japan Recruiting
Novo Nordisk Investigational Site | Ibaraki, 311-0113, Japan Recruiting
Novo Nordisk Investigational Site | Kishiwada, Osaka, 596-0042, Japan Not yet recruiting
Novo Nordisk Investigational Site | Kita-azumi-gun, Nagano, 399-8695, Japan Not yet recruiting
Novo Nordisk Investigational Site | Kumamoto-shi, Kumamoto, 860-8556, Japan Not yet recruiting
Novo Nordisk Investigational Site | Kumamoto, 862-0976, Japan Recruiting
Novo Nordisk Investigational Site | Kusegun, Kyoto, 613-0034, Japan Not yet recruiting
Novo Nordisk Investigational Site | Kyoto-shi, Kyoto, 607-8062, Japan Not yet recruiting
Novo Nordisk Investigational Site | Kyoto-shi,Kyoto, 601-1495, Japan Not yet recruiting
Novo Nordisk Investigational Site | Matsudo-shi, 270-2251, Japan Not yet recruiting
Novo Nordisk Investigational Site | Meguro-ku, Tokyo, 153-0051, Japan Not yet recruiting
Novo Nordisk Investigational Site | Naha-shi, Okinawa, 902-8511, Japan Not yet recruiting
Novo Nordisk Investigational Site | Okayama, 701-0192, Japan Not yet recruiting
Novo Nordisk Investigational Site | Omihachiman-shi, Siga, 523-0082, Japan Not yet recruiting
Novo Nordisk Investigational Site | Osaka-shi, Osaka, 533-0024, Japan Not yet recruiting
Novo Nordisk Investigational Site | Osaka-shi,Osaka, 559-0012, Japan Not yet recruiting
Novo Nordisk Investigational Site | Sapporo-shi, Hokkaido, 062-0003, Japan Not yet recruiting
Novo Nordisk Investigational Site | Sendai-shi, Miyagi, 980-8574, Japan Not yet recruiting
Novo Nordisk Investigational Site | Takamatsu-shi, Kagawa, 760-8557, Japan Recruiting
Novo Nordisk Investigational Site | Yao-shi, Osaka, 581-0011, Japan Not yet recruiting
Novo Nordisk Investigational Site | Yonezawa-shi, Yamagata, 992-0045, Japan Recruiting
Novo Nordisk Investigational Site | Busan, 49201, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Busan, 49241, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Daegu, 42472, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Daegu, 42601, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Daejeon, 35015, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Gangwon-do, 26426, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Gwangju, 61469, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Gyeonggi-do, 13620, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Incheon, 21565, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Seoul, 02841, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Seoul, 03722, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Seoul, 05278, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Seoul, 08308, Korea, Republic of Not yet recruiting
Novo Nordisk Investigational Site | Kaunas, 48259, Lithuania Not yet recruiting
Novo Nordisk Investigational Site | Kaunas, 49449, Lithuania Recruiting
Novo Nordisk Investigational Site | Siauliai, 76231, Lithuania Recruiting
Novo Nordisk Investigational Site | Alor Setar, 05460, Malaysia Recruiting
Novo Nordisk Investigational Site | Ipoh, Perak, 30450, Malaysia Not yet recruiting
Novo Nordisk Investigational Site | Kedah, 08000, Malaysia Recruiting
Novo Nordisk Investigational Site | Kota Bharu, Kelantan, 16150, Malaysia Recruiting
Novo Nordisk Investigational Site | Kota Bharu, 15586, Malaysia Not yet recruiting
Novo Nordisk Investigational Site | Kota Samarahan, 94300, Malaysia Recruiting
Novo Nordisk Investigational Site | Kuala Lumpur, 59100, Malaysia Not yet recruiting
Novo Nordisk Investigational Site | Sabah, 88300, Malaysia Recruiting
Novo Nordisk Investigational Site | Seremban, 70300, Malaysia Recruiting
Novo Nordisk Investigational Site | Mexico City, México, D.F., 03300, Mexico Recruiting
Novo Nordisk Investigational Site | Monterrey, Nuevo León, 64020, Mexico Recruiting
Novo Nordisk Investigational Site | Monterrey, Nuevo León, 64060, Mexico Not yet recruiting
Novo Nordisk Investigational Site | Monterrey, Nuevo León, 64460, Mexico Recruiting
Novo Nordisk Investigational Site | San Luis Potosí, San Luis Potosi, 78200, Mexico Recruiting
Novo Nordisk Investigational Site | Culiacán, Sinaloa, 80230, Mexico Recruiting
Novo Nordisk Investigational Site | Aguascalientes, 20230, Mexico Recruiting
Novo Nordisk Investigational Site | Queretaro, 76000, Mexico Recruiting
Novo Nordisk Investigational Site | Veracruz, 91900, Mexico Recruiting
Novo Nordisk Investigational Site | Alkmaar, 1815 JD, Netherlands Recruiting
Novo Nordisk Investigational Site | Almelo, 7609 PP, Netherlands Not yet recruiting
Novo Nordisk Investigational Site | Amsterdam, 1105 AZ, Netherlands Recruiting
Novo Nordisk Investigational Site | Apeldoorn, 7334 DZ, Netherlands Recruiting
Novo Nordisk Investigational Site | Hilversum, 1213 XZ, Netherlands Not yet recruiting
Novo Nordisk Investigational Site | Rotterdam, 3083 AN, Netherlands Recruiting
Novo Nordisk Investigational Site | Sneek, 8601 ZR, Netherlands Recruiting
Novo Nordisk Investigational Site | Zaandam, 1502 DV, Netherlands Not yet recruiting
Novo Nordisk Investigational Site | Bialystok, 15-481, Poland Not yet recruiting
Novo Nordisk Investigational Site | Elblag, 82-300, Poland Recruiting
Novo Nordisk Investigational Site | Gorzow Wielkopolski, 66-400, Poland Recruiting
Novo Nordisk Investigational Site | Krakow, 30-082, Poland Recruiting
Novo Nordisk Investigational Site | Krakow, 31-209, Poland Recruiting
Novo Nordisk Investigational Site | Krakow, 31-261, Poland Not yet recruiting
Novo Nordisk Investigational Site | Kraków, 31-202, Poland Recruiting
Novo Nordisk Investigational Site | Lodz, 90-242, Poland Recruiting
Novo Nordisk Investigational Site | Lodz, 90-549, Poland Recruiting
Novo Nordisk Investigational Site | Lodz, 91-211, Poland Recruiting
Novo Nordisk Investigational Site | Pulawy, 24-100, Poland Recruiting
Novo Nordisk Investigational Site | Szczecin, 70-341, Poland Recruiting
Novo Nordisk Investigational Site | Warszawa, 04-628, Poland Recruiting
Novo Nordisk Investigational Site | Warszawa, 04-628, Poland Not yet recruiting
Novo Nordisk Investigational Site | Wroclaw, 51-162, Poland Not yet recruiting
Novo Nordisk Investigational Site | Zamosc, 22-400, Poland Recruiting
Novo Nordisk Investigational Site | Almada, 2805-267, Portugal Not yet recruiting
Novo Nordisk Investigational Site | Aveiro, 3814-501, Portugal Not yet recruiting
Novo Nordisk Investigational Site | Matosinhos, 4464-513, Portugal Not yet recruiting
Novo Nordisk Investigational Site | Novosibirsk, 630099, Russian Federation Recruiting
Novo Nordisk Investigational Site | Sochi, 354057, Russian Federation Not yet recruiting
Novo Nordisk Investigational Site | Bratislava, 81369, Slovakia Recruiting
Novo Nordisk Investigational Site | Bratislava, 83305, Slovakia Not yet recruiting
Novo Nordisk Investigational Site | Kosice, 040 01, Slovakia Recruiting
Novo Nordisk Investigational Site | Lubochna, 03491, Slovakia Recruiting
Novo Nordisk Investigational Site | Martin, 036 59, Slovakia Suspended
Novo Nordisk Investigational Site | Presov, 08-181, Slovakia Not yet recruiting
Novo Nordisk Investigational Site | Bloemfontein, Free State, 9301, South Africa Not yet recruiting
Novo Nordisk Investigational Site | Bloemfontein, Free State, 9301, South Africa Recruiting
Novo Nordisk Investigational Site | Centurion, Gauteng, 0157, South Africa Recruiting
Novo Nordisk Investigational Site | Johannesburg, Gauteng, 2013, South Africa Not yet recruiting
Novo Nordisk Investigational Site | Johannesburg, Gauteng, 2157, South Africa Suspended
Novo Nordisk Investigational Site | Johannesburg, Gauteng, 2193, South Africa Recruiting
Novo Nordisk Investigational Site | Pretoria, Gauteng, 0183, South Africa Not yet recruiting
Novo Nordisk Investigational Site | Pretoria, Gauteng, 0184, South Africa Recruiting
Novo Nordisk Investigational Site | Pretoria, Gauteng, 0186, South Africa Not yet recruiting
Novo Nordisk Investigational Site | Cape Town, Western Cape, 7130, South Africa Recruiting
Novo Nordisk Investigational Site | Cape Town, Western Cape, 7130, South Africa Not yet recruiting
Novo Nordisk Investigational Site | Cape Town, Western Cape, 7500, South Africa Recruiting
Novo Nordisk Investigational Site | Paarl, Western Cape, 7646, South Africa Recruiting
Novo Nordisk Investigational Site | Baracaldo, 48903, Spain Not yet recruiting
Novo Nordisk Investigational Site | Córdoba, 14004, Spain Not yet recruiting
Novo Nordisk Investigational Site | L' Hospitalet Del Llobregat, 08907, Spain Not yet recruiting
Novo Nordisk Investigational Site | Sanlúcar de Barrameda, 11540, Spain Not yet recruiting
Novo Nordisk Investigational Site | Valencia, 46010, Spain Not yet recruiting
Novo Nordisk Investigational Site | Valencia, 46017, Spain Not yet recruiting
Novo Nordisk Investigational Site | Zaragoza, 50009, Spain Not yet recruiting
Novo Nordisk Investigational Site | Malmö, 205 02, Sweden Not yet recruiting
Novo Nordisk Investigational Site | Stockholm, 141 85, Sweden Not yet recruiting
Novo Nordisk Investigational Site | Stockholm, 171 64, Sweden Not yet recruiting
Novo Nordisk Investigational Site | Hsinchu City, 300, Taiwan Not yet recruiting
Novo Nordisk Investigational Site | Tainan City, 704, Taiwan Not yet recruiting
Novo Nordisk Investigational Site | Taipei, 100, Taiwan Not yet recruiting
Novo Nordisk Investigational Site | Taipei, 112, Taiwan Recruiting
Novo Nordisk Investigational Site | Afyon, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Ankara, 06230, Turkey Recruiting
Novo Nordisk Investigational Site | Antalya, 07058, Turkey Recruiting
Novo Nordisk Investigational Site | Eskisehir, 26040, Turkey Recruiting
Novo Nordisk Investigational Site | Istanbul, 34098, Turkey Recruiting
Novo Nordisk Investigational Site | Istanbul, 34098, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Istanbul, 34381, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Istanbul, 34668, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Izmir, 35100, Turkey Recruiting
Novo Nordisk Investigational Site | Izmir, 35340, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Kahramanmaras, 46040, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Kayseri, 38039, Turkey Recruiting
Novo Nordisk Investigational Site | Kocaeli, 41380, Turkey Recruiting
Novo Nordisk Investigational Site | Mugla, 48000, Turkey Not yet recruiting
Novo Nordisk Investigational Site | Chernivtsi, 58023, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Ivano-Frankivsk, 76008, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kharkiv, 61039, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kharkiv, 61178, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kyiv, 02091, Ukraine Recruiting
Novo Nordisk Investigational Site | Kyiv, 02660, Ukraine Recruiting
Novo Nordisk Investigational Site | Kyiv, 03037, Ukraine Recruiting
Novo Nordisk Investigational Site | Kyiv, 03049, Ukraine Recruiting
Novo Nordisk Investigational Site | Kyiv, 03151, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kyiv, 03680, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kyiv, 04050, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Kyiv, 04053, Ukraine Not yet recruiting
Novo Nordisk Investigational Site | Zaporizhzhia, 69063, Ukraine Not yet recruiting