ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
Название протокола
Клинические исследование Cardiovascular Risk: Ziltivekimab, Placebo (ziltivekimab) - Реестр клинических исследований
Платное
Нет
Дата начала и окончания КИ
2022-02-06 - 2022-02-06
Спонсоры
Ведущий спонсор:
Novo Nordisk A/S
Источник
Novo Nordisk A/S
Краткое содержание
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe. Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits. Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
Общий статус
Recruiting
Дата начала
2021-08-30
Дата завершения
2025-10-15
Дата первичного завершения
2025-09-24
Фаза
Phase 3
Тип исследования
Interventional
Первичный результат
Мера
Временное ограничение
Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: Cardiovascular (CV ) death (Based on EAC-confirmed events; including undetermined cause of death)
From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of 3-point MACE, a composite endpoint consisting of: non-fatal myocardial infarction(MI) ( Based on EAC-confirmed events; including undetermined cause of death; acute MI only)
From randomisation (month 0) to end-of-study (up to 48 months)
Time to first occurrence of 3-point MACE, a composite endpoint consisting of: non-fatal stroke (Based on EAC-confirmed events; including ischaemic, haemorrhagic and undetermined stroke)
From randomisation (month 0) to end-of-study (up to 48 months)
Вторичный результат
Мера
Временное ограничение
Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death (Based on EAC-confirmed events; including undetermined cause of death
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: non-fatal MI (Based on EAC-confirmed events; acute MI only)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: non-fatal stroke (Based on EAC-confirmed events; including ischaemic, haemorrhagic and undetermined stroke)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of expanded MACE, a composite endpoint consisting of: hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Number of hospitalisations for heart failure (Based on EAC-confirmed events) or urgent heart failure visit (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to occurrence of all-cause mortality (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of:onset of persistent greater than or equal to 40% reduction in eGFR (CKD-EPI) compared with baseline
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of kidney failure defined as:death from kidney failure
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of:kidney failure defined as onset of persistente eGFR below 15 mL/min/1.73 m^2 (CKD-EPI)
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of a composite CKD endpoint consisting of: initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months) (Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-month follow-up period)
Time to first occurrence of each of the individual components (Based on EAC-confirmed events) of the expanded MACE endpoint and the kidney composite endpoint
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of MIs (acute MI only) (fatal and non-fatal) (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of stroke (including ischaemic, haemorrhagic and undetermined stroke) (fatal and non-fatal)(Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:all-cause mortality (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:non-fatal MI (Based on EAC-confirmed events; acute MI only)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of a composite MACE endpoint consisting of:non-fatal stroke (Based on EAC-confirmed events,including ischaemic, haemorrhagic and undetermined stroke)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:CV death (Based on EAC-confirmed events; including undetermined cause of death)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:onset of persistent greater than or equal to 40% reduction in eGFR (CKD-EPI) compared with baseline
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as:death from kidney failure
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as onset of persistent eGFR below 15 mL/min/1.73 m^2 (CKD-EPI)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of an expanded composite kidney endpoint consisting of:kidney failure defined as:initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation) (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Time to first occurrence of coronary revascularisation
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in UACR (urinary albumin-to-creatinine ratio )
From randomisation (month 0) to 2 years (24 months)
From randomisation (month 0) to 2 years (24 months)
Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in high-sensitivity C-reactive protein (hs-CRP)
From randomisation (month 0) to 2 years (24 months
Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)
From randomisation (month 0) to 2 years (24 months)
Change in left ventricular ejection fraction (LVEF)
From randomisation (month 0) to 2 years (24 months)
Number of events of atrial fibrillation
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Number of hospitalisations with infection as primary cause (Based on EAC-confirmed events) or death due to infection (Based on EAC-confirmed events)
From randomisation (month 0) to end-of-study (up to 48 months)(Maximum treatment duration is dependent on event rates and is estimated to be approximately 48 months including a 3-months follow-up period;)
Change in Short Form 36 (SF-36) Physical Component Score (PCS)
From randomisation (month 0) to 2 years (24 months)
Регистрация
6200
Состояние
Cardiovascular Risk
Chronic Kidney Disease
Inflammation
Вмешательство
Тип вмешательства:
Drug
Название вмешательства:
Ziltivekimab
Описание:
Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care
Этикетка Arm Group:
ziltivekimab 15 mg
Тип вмешательства:
Drug
Название вмешательства:
Placebo (ziltivekimab)
Описание:
Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care
Этикетка Arm Group:
Placebo (ziltivekimab)
Приемлемость
Критерии:
Inclusion Criteria: - Estimated glomerular filtration rate (eGFR) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation) - Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 mg/L at screening (visit 1) - Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following within the last 5 years from screening: a) Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound. c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis). Exclusion Criteria: - Clinical evidence of, or suspicion of, active infection at the discretion of the investigator. - Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2). - Planned coronary, carotid or peripheral artery revascularisation known on the day of screening (visit 1). - Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
Пол:
All
Минимальный возраст:
18 Years
Максимальный возраст:
N/A
Здоровые волонтеры:
No
Общий Официальный
Фамилия
Роль
Присоединение
Clinical Transparency (dept. 1452)
Study Director
Novo Nordisk A/S
Общий контакт
Фамилия:
Novo Nordisk
Телефон:
(+1) 866-867-7178
Расположение
Объект:
Положение дел:
Novo Nordisk Investigational Site
| Birmingham, Alabama, 35294, United States
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| Montgomery, Alabama, 36106, United States
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| Glendale, Arizona, 85308, United States
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| Mesa, Arizona, 85210, United States
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| Searcy, Arkansas, 72143, United States
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| Covina, California, 91723, United States
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| La Jolla, California, 92037, United States
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| La Mesa, California, 91942, United States
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| Lancaster, California, 93534, United States
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| Los Alamitos, California, 90720, United States
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| Lynwood, California, 90262, United States
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| Northridge, California, 91325, United States
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| Palm Springs, California, 92262, United States
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| Riverside, California, 92503, United States
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| S. Gate, California, 90280, United States
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| San Dimas, California, 91773, United States
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| Torrance, California, 90502, United States
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| Bridgeport, Connecticut, 06610, United States
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| West Haven, Connecticut, 06516, United States
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| Boca Raton, Florida, 33434, United States
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| Boynton Beach, Florida, 33437, United States
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Novo Nordisk Investigational Site
| Clearwater, Florida, 33756, United States
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Novo Nordisk Investigational Site
| Fleming Island, Florida, 32003, United States
Recruiting
Novo Nordisk Investigational Site
| Hollywood, Florida, 33021, United States
Recruiting
Novo Nordisk Investigational Site
| Jacksonville, Florida, 32204, United States
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| Miami Lakes, Florida, 33014, United States
Recruiting
Novo Nordisk Investigational Site
| Miami, Florida, 33126, United States
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| Miami, Florida, 33130, United States
Recruiting
Novo Nordisk Investigational Site
| Miami, Florida, 33155, United States
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| New Port Richey, Florida, 34652, United States
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| Palm Harbor, Florida, 34684, United States
Recruiting
Novo Nordisk Investigational Site
| Pembroke Pines, Florida, 33024, United States
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| Pembroke Pines, Florida, 33027, United States
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| Port Charlotte, Florida, 33952, United States
Recruiting
Novo Nordisk Investigational Site
| Port Charlotte, Florida, 33952, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Saint Augustine, Florida, 32080, United States
Recruiting
Novo Nordisk Investigational Site
| Saint Augustine, Florida, 32086, United States
Recruiting
Novo Nordisk Investigational Site
| Winter Haven, Florida, 33880, United States
Recruiting
Novo Nordisk Investigational Site
| Augusta, Georgia, 30904, United States
Recruiting
Novo Nordisk Investigational Site
| Conyers, Georgia, 30094, United States
Recruiting
Novo Nordisk Investigational Site
| Johns Creek, Georgia, 30024, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Roswell, Georgia, 30076, United States
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| Savannah, Georgia, 31406, United States
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| Nampa, Idaho, 83686-6011, United States
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| Arlington Heights, Illinois, 60005, United States
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| Gurnee, Illinois, 60031, United States
Recruiting
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| Hazel Crest, Illinois, 60429, United States
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| Skokie, Illinois, 60077, United States
Recruiting
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| Springfield, Illinois, 62711, United States
Recruiting
Novo Nordisk Investigational Site
| Wauconda, Illinois, 60084, United States
Not yet recruiting
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| Evansville, Indiana, 47714, United States
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| Valparaiso, Indiana, 46383, United States
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| Overland Park, Kansas, 66211, United States
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| Topeka, Kansas, 66606, United States
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| Lexington, Kentucky, 40503, United States
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| Louisville, Kentucky, 40205, United States
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| Bossier City, Louisiana, 71111, United States
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| Monroe, Louisiana, 71201, United States
Recruiting
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| Slidell, Louisiana, 70458, United States
Recruiting
Novo Nordisk Investigational Site
| West Monroe, Louisiana, 71201, United States
Recruiting
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| Annapolis, Maryland, 21401, United States
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| Bethesda, Maryland, 20814, United States
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| Camp Springs, Maryland, 20746, United States
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| Boston, Massachusetts, 02115-5804, United States
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| Haverhill, Massachusetts, 01830, United States
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Novo Nordisk Investigational Site
| Detroit, Michigan, 48202, United States
Recruiting
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| Flint, Michigan, 48532, United States
Recruiting
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| Grand Rapids, Michigan, 49546, United States
Not yet recruiting
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| Minneapolis, Minnesota, 55407, United States
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| Kansas City, Missouri, 64111, United States
Recruiting
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| Saint Louis, Missouri, 63128, United States
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| Saint Louis, Missouri, 63136, United States
Recruiting
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| Lincoln, Nebraska, 68526, United States
Recruiting
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| Omaha, Nebraska, 68105, United States
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| Omaha, Nebraska, 68114, United States
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| Omaha, Nebraska, 68198-3020, United States
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| Las Vegas, Nevada, 89128, United States
Recruiting
Novo Nordisk Investigational Site
| Bridgewater, New Jersey, 08807-3064, United States
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| Northport, New York, 11768, United States
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| Ridgewood, New York, 11385, United States
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| Saratoga Springs, New York, 12866, United States
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Novo Nordisk Investigational Site
| West Seneca, New York, 14224, United States
Recruiting
Novo Nordisk Investigational Site
| Westfield, New York, 14787, United States
Not yet recruiting
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| Asheville, North Carolina, 28801, United States
Recruiting
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| Burlington, North Carolina, 27215, United States
Not yet recruiting
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| Chapel Hill, North Carolina, 27599, United States
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| Charlotte, North Carolina, 28207, United States
Not yet recruiting
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| Greensboro, North Carolina, 27408, United States
Recruiting
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| Greenville, North Carolina, 27834, United States
Recruiting
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| Morehead City, North Carolina, 28557-4346, United States
Recruiting
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| Fargo, North Dakota, 58104, United States
Recruiting
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| Cleveland, Ohio, 44106, United States
Not yet recruiting
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| Maumee, Ohio, 43537, United States
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| Bethlehem, Pennsylvania, 18017, United States
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| Philadelphia, Pennsylvania, 19114, United States
Recruiting
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| Philadelphia, Pennsylvania, 19144, United States
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| Lincoln, Rhode Island, 02865, United States
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| Fort Mill, South Carolina, 29707, United States
Recruiting
Novo Nordisk Investigational Site
| Greenville, South Carolina, 29615, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Myrtle Beach, South Carolina, 29588, United States
Suspended
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| Spartanburg, South Carolina, 29303, United States
Not yet recruiting
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| Chattanooga, Tennessee, 37411, United States
Recruiting
Novo Nordisk Investigational Site
| Greeneville, Tennessee, 37745, United States
Recruiting
Novo Nordisk Investigational Site
| Knoxville, Tennessee, 37934, United States
Recruiting
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| Memphis, Tennessee, 38119, United States
Not yet recruiting
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| Arlington, Texas, 76012-4637, United States
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| Corpus Christi, Texas, 78414, United States
Recruiting
Novo Nordisk Investigational Site
| Dallas, Texas, 75208, United States
Recruiting
Novo Nordisk Investigational Site
| Dallas, Texas, 75230, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Dallas, Texas, 75235, United States
Not yet recruiting
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| Edinburg, Texas, 78539, United States
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| El Paso, Texas, 79935, United States
Recruiting
Novo Nordisk Investigational Site
| Forney, Texas, 75126, United States
Recruiting
Novo Nordisk Investigational Site
| Fort Worth, Texas, 76132, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Fort Worth, Texas, 76133, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77024, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77043, United States
Recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77054, United States
Recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77079, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77084, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Houston, Texas, 77090, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Live Oak, Texas, 78233, United States
Recruiting
Novo Nordisk Investigational Site
| Longview, Texas, 75605, United States
Recruiting
Novo Nordisk Investigational Site
| Lufkin, Texas, 75904, United States
Recruiting
Novo Nordisk Investigational Site
| San Antonio, Texas, 78212, United States
Recruiting
Novo Nordisk Investigational Site
| San Antonio, Texas, 78215, United States
Recruiting
Novo Nordisk Investigational Site
| San Antonio, Texas, 78224, United States
Not yet recruiting
Novo Nordisk Investigational Site
| San Antonio, Texas, 78230, United States
Recruiting
Novo Nordisk Investigational Site
| San Marcos, Texas, 78666, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Sugar Land, Texas, 77478, United States
Recruiting
Novo Nordisk Investigational Site
| Waco, Texas, 76708, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Webster, Texas, 77598, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Forest, Virginia, 24551, United States
Not yet recruiting
Novo Nordisk Investigational Site
| Norfolk, Virginia, 23510-2015, United States
Recruiting
Novo Nordisk Investigational Site
| Salem, Virginia, 24153-6404, United States
Recruiting
Novo Nordisk Investigational Site
| Winchester, Virginia, 22601-3834, United States
Recruiting
Novo Nordisk Investigational Site
| Wausau, Wisconsin, 54401, United States
Recruiting
Novo Nordisk Investigational Site
| Buenos Aires, B6000BHA, Argentina
Not yet recruiting
Novo Nordisk Investigational Site
| Caba, C1213, Argentina
Not yet recruiting
Novo Nordisk Investigational Site
| Caba, C1428ART, Argentina
Not yet recruiting
Novo Nordisk Investigational Site
| Caba, C1440CFD, Argentina
Recruiting
Novo Nordisk Investigational Site
| Ciudad Autónoma de Buenos Aire, 1425, Argentina
Recruiting
Novo Nordisk Investigational Site
| Mar del Plata, B7600GNY, Argentina
Not yet recruiting
Novo Nordisk Investigational Site
| Quilmes - Buenos Aires, B1878DVB, Argentina
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| San Nicolás, B2900, Argentina
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Novo Nordisk Investigational Site
| Garran, Australian Capital Territory, 2605, Australia
Recruiting
Novo Nordisk Investigational Site
| Gosford, New South Wales, 2250, Australia
Recruiting
Novo Nordisk Investigational Site
| Milton, Queensland, 4064, Australia
Recruiting
Novo Nordisk Investigational Site
| Adelaide, South Australia, 5000, Australia
Not yet recruiting
Novo Nordisk Investigational Site
| Clayton, Victoria, 3168, Australia
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Novo Nordisk Investigational Site
| Fitzroy, Victoria, 3065, Australia
Not yet recruiting
Novo Nordisk Investigational Site
| Geelong, Victoria, 3220, Australia
Not yet recruiting
Novo Nordisk Investigational Site
| Joondalup, Western Australia, 6027, Australia
Recruiting
Novo Nordisk Investigational Site
| Aalst, 9300, Belgium
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Novo Nordisk Investigational Site
| Brasschaat, 2930, Belgium
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Novo Nordisk Investigational Site
| Brugge, 8000, Belgium
Recruiting
Novo Nordisk Investigational Site
| Genk, 3600, Belgium
Recruiting
Novo Nordisk Investigational Site
| Kortrijk, 8500, Belgium
Recruiting
Novo Nordisk Investigational Site
| Liège, 4000, Belgium
Not yet recruiting
Novo Nordisk Investigational Site
| Mechelen, 2800, Belgium
Not yet recruiting
Novo Nordisk Investigational Site
| Curitiba, Parana, 80440-020, Brazil
Not yet recruiting
Novo Nordisk Investigational Site
| Pleven, 5800, Bulgaria
Recruiting
Novo Nordisk Investigational Site
| Plovdiv, 4002, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Sofia, 1309, Bulgaria
Recruiting
Novo Nordisk Investigational Site
| Sofia, 1407, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Sofia, 1431, Bulgaria
Recruiting
Novo Nordisk Investigational Site
| Sofia, 1431, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Sofia, 1527, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Sofia, 1750, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Sofia, 1750, Bulgaria
Recruiting
Novo Nordisk Investigational Site
| Varna, 9010, Bulgaria
Not yet recruiting
Novo Nordisk Investigational Site
| Calgary, Alberta, T2H 2G4, Canada
Recruiting
Novo Nordisk Investigational Site
| Calgary, Alberta, T2V 4J2, Canada
Recruiting
Novo Nordisk Investigational Site
| Vancouver, British Columbia, V5Y 3W2, Canada
Recruiting
Novo Nordisk Investigational Site
| Halifax, Nova Scotia, B3H 2Y9, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Barrie, Ontario, L4N 7L3, Canada
Recruiting
Novo Nordisk Investigational Site
| Brampton, Ontario, L6S 0C6, Canada
Recruiting
Novo Nordisk Investigational Site
| Concord, Ontario, L4K 4M2, Canada
Recruiting
Novo Nordisk Investigational Site
| Etobicoke, Ontario, M9R 4E1, Canada
Recruiting
Novo Nordisk Investigational Site
| Hamilton, Ontario, L8M 1K7, Canada
Recruiting
Novo Nordisk Investigational Site
| Nepean, Ontario, K2J 0V2, Canada
Recruiting
Novo Nordisk Investigational Site
| North York, Ontario, M6B 3H7, Canada
Recruiting
Novo Nordisk Investigational Site
| Oakville, Ontario, L6K 3W7, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Oakville, Ontario, L6M 1M1, Canada
Recruiting
Novo Nordisk Investigational Site
| Peterborough, Ontario, K9J 0B2, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Scarborough, Ontario, M1B 4Z8, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Toronto, Ontario, M4G 3E8, Canada
Recruiting
Novo Nordisk Investigational Site
| Toronto, Ontario, M6G 1M2, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Waterloo, Ontario, N2T 0C1, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Brossard, Quebec, J4Z-2K9, Canada
Recruiting
Novo Nordisk Investigational Site
| Laval, Quebec, H7T 2P5, Canada
Recruiting
Novo Nordisk Investigational Site
| Quebec, G1G 3Y8, Canada
Not yet recruiting
Novo Nordisk Investigational Site
| Beijing, Beijing, 100853, China
Not yet recruiting
Novo Nordisk Investigational Site
| Aarhus N, 8200, Denmark
Not yet recruiting
Novo Nordisk Investigational Site
| Herning, 7400, Denmark
Recruiting
Novo Nordisk Investigational Site
| Hvidovre, 2650, Denmark
Recruiting
Novo Nordisk Investigational Site
| Svendborg, 5700, Denmark
Recruiting
Novo Nordisk Investigational Site
| Aachen, 52074, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Bad Homburg, 61348, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Dresden, 01277, Germany
Suspended
Novo Nordisk Investigational Site
| Düsseldorf, 40210, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Elsterwerda, 04910, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Essen, 45136, Germany
Recruiting
Novo Nordisk Investigational Site
| Falkensee, 14612, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Lübeck, 23562, Germany
Not yet recruiting
Novo Nordisk Investigational Site
| Oldenburg I. Holst, 23758, Germany
Recruiting
Novo Nordisk Investigational Site
| Witten, 58455, Germany
Suspended
Novo Nordisk Investigational Site
| Athens, 11527, Greece
Not yet recruiting
Novo Nordisk Investigational Site
| Athens, GR-11527, Greece
Not yet recruiting
Novo Nordisk Investigational Site
| Athens, GR-11528, Greece
Recruiting
Novo Nordisk Investigational Site
| Athens, GR-14233, Greece
Recruiting
Novo Nordisk Investigational Site
| Athens, GR-15123, Greece
Recruiting
Novo Nordisk Investigational Site
| Chios, GR82100, Greece
Recruiting
Novo Nordisk Investigational Site
| Haidari-Athens, GR-12462, Greece
Recruiting
Novo Nordisk Investigational Site
| Ioannina, 45500, Greece
Not yet recruiting
Novo Nordisk Investigational Site
| Kifissia, GR-14561, Greece
Recruiting
Novo Nordisk Investigational Site
| Lamia, GR35100, Greece
Not yet recruiting
Novo Nordisk Investigational Site
| Larissa, GR-41110, Greece
Recruiting
Novo Nordisk Investigational Site
| Patra, GR-26504, Greece
Recruiting
Novo Nordisk Investigational Site
| Thessaloniki, GR-57010, Greece
Not yet recruiting
Novo Nordisk Investigational Site
| Vijayawada, Andhra Pradesh, 520002, India
Recruiting
Novo Nordisk Investigational Site
| Mangalore, Karnataka, 575002, India
Recruiting
Novo Nordisk Investigational Site
| Manipal, Karnataka, 576104, India
Recruiting
Novo Nordisk Investigational Site
| Nagpur, Maharashtra, 440003, India
Recruiting
Novo Nordisk Investigational Site
| Hyderabad, Telengana, 500012, India
Recruiting
Novo Nordisk Investigational Site
| Belgaum, 590010, India
Recruiting
Novo Nordisk Investigational Site
| Holon, 58100, Israel
Recruiting
Novo Nordisk Investigational Site
| Jerusalem, 91120, Israel
Recruiting
Novo Nordisk Investigational Site
| Rehovot, 7661041, Israel
Recruiting
Novo Nordisk Investigational Site
| Tel Aviv, 6423906, Israel
Recruiting
Novo Nordisk Investigational Site
| Tel Hashomer, 5265601, Israel
Recruiting
Novo Nordisk Investigational Site
| Catanzaro, 88100, Italy
Not yet recruiting
Novo Nordisk Investigational Site
| Milano, 20138, Italy
Not yet recruiting
Novo Nordisk Investigational Site
| Milan, 20132, Italy
Not yet recruiting
Novo Nordisk Investigational Site
| Montichiari, 25018, Italy
Not yet recruiting
Novo Nordisk Investigational Site
| Rome, 00189, Italy
Recruiting
Novo Nordisk Investigational Site
| Verona, 37126, Italy
Recruiting
Novo Nordisk Investigational Site
| Bunkyo-ku, Tokyo, 113-8655, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Fukushima, 963-8851, Japan
Recruiting
Novo Nordisk Investigational Site
| Ibaraki, 311-0113, Japan
Recruiting
Novo Nordisk Investigational Site
| Kishiwada, Osaka, 596-0042, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Kita-azumi-gun, Nagano, 399-8695, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Kumamoto-shi, Kumamoto, 860-8556, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Kumamoto, 862-0976, Japan
Recruiting
Novo Nordisk Investigational Site
| Kusegun, Kyoto, 613-0034, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Kyoto-shi, Kyoto, 607-8062, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Kyoto-shi,Kyoto, 601-1495, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Matsudo-shi, 270-2251, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Meguro-ku, Tokyo, 153-0051, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Naha-shi, Okinawa, 902-8511, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Okayama, 701-0192, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Omihachiman-shi, Siga, 523-0082, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Osaka-shi, Osaka, 533-0024, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Osaka-shi,Osaka, 559-0012, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Sapporo-shi, Hokkaido, 062-0003, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Sendai-shi, Miyagi, 980-8574, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Takamatsu-shi, Kagawa, 760-8557, Japan
Recruiting
Novo Nordisk Investigational Site
| Yao-shi, Osaka, 581-0011, Japan
Not yet recruiting
Novo Nordisk Investigational Site
| Yonezawa-shi, Yamagata, 992-0045, Japan
Recruiting
Novo Nordisk Investigational Site
| Busan, 49201, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Busan, 49241, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Daegu, 42472, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Daegu, 42601, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Daejeon, 35015, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Gangwon-do, 26426, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Gwangju, 61469, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Gyeonggi-do, 13620, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Incheon, 21565, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Seoul, 02841, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Seoul, 03722, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Seoul, 05278, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Seoul, 08308, Korea, Republic of
Not yet recruiting
Novo Nordisk Investigational Site
| Kaunas, 48259, Lithuania
Not yet recruiting
Novo Nordisk Investigational Site
| Kaunas, 49449, Lithuania
Recruiting
Novo Nordisk Investigational Site
| Siauliai, 76231, Lithuania
Recruiting
Novo Nordisk Investigational Site
| Alor Setar, 05460, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Ipoh, Perak, 30450, Malaysia
Not yet recruiting
Novo Nordisk Investigational Site
| Kedah, 08000, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Kota Bharu, Kelantan, 16150, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Kota Bharu, 15586, Malaysia
Not yet recruiting
Novo Nordisk Investigational Site
| Kota Samarahan, 94300, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Kuala Lumpur, 59100, Malaysia
Not yet recruiting
Novo Nordisk Investigational Site
| Sabah, 88300, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Seremban, 70300, Malaysia
Recruiting
Novo Nordisk Investigational Site
| Mexico City, México, D.F., 03300, Mexico
Recruiting
Novo Nordisk Investigational Site
| Monterrey, Nuevo León, 64020, Mexico
Recruiting
Novo Nordisk Investigational Site
| Monterrey, Nuevo León, 64060, Mexico
Not yet recruiting
Novo Nordisk Investigational Site
| Monterrey, Nuevo León, 64460, Mexico
Recruiting
Novo Nordisk Investigational Site
| San Luis Potosí, San Luis Potosi, 78200, Mexico
Recruiting
Novo Nordisk Investigational Site
| Culiacán, Sinaloa, 80230, Mexico
Recruiting
Novo Nordisk Investigational Site
| Aguascalientes, 20230, Mexico
Recruiting
Novo Nordisk Investigational Site
| Queretaro, 76000, Mexico
Recruiting
Novo Nordisk Investigational Site
| Veracruz, 91900, Mexico
Recruiting
Novo Nordisk Investigational Site
| Alkmaar, 1815 JD, Netherlands
Recruiting
Novo Nordisk Investigational Site
| Almelo, 7609 PP, Netherlands
Not yet recruiting
Novo Nordisk Investigational Site
| Amsterdam, 1105 AZ, Netherlands
Recruiting
Novo Nordisk Investigational Site
| Apeldoorn, 7334 DZ, Netherlands
Recruiting
Novo Nordisk Investigational Site
| Hilversum, 1213 XZ, Netherlands
Not yet recruiting
Novo Nordisk Investigational Site
| Rotterdam, 3083 AN, Netherlands
Recruiting
Novo Nordisk Investigational Site
| Sneek, 8601 ZR, Netherlands
Recruiting
Novo Nordisk Investigational Site
| Zaandam, 1502 DV, Netherlands
Not yet recruiting
Novo Nordisk Investigational Site
| Bialystok, 15-481, Poland
Not yet recruiting
Novo Nordisk Investigational Site
| Elblag, 82-300, Poland
Recruiting
Novo Nordisk Investigational Site
| Gorzow Wielkopolski, 66-400, Poland
Recruiting
Novo Nordisk Investigational Site
| Krakow, 30-082, Poland
Recruiting
Novo Nordisk Investigational Site
| Krakow, 31-209, Poland
Recruiting
Novo Nordisk Investigational Site
| Krakow, 31-261, Poland
Not yet recruiting
Novo Nordisk Investigational Site
| Kraków, 31-202, Poland
Recruiting
Novo Nordisk Investigational Site
| Lodz, 90-242, Poland
Recruiting
Novo Nordisk Investigational Site
| Lodz, 90-549, Poland
Recruiting
Novo Nordisk Investigational Site
| Lodz, 91-211, Poland
Recruiting
Novo Nordisk Investigational Site
| Pulawy, 24-100, Poland
Recruiting
Novo Nordisk Investigational Site
| Szczecin, 70-341, Poland
Recruiting
Novo Nordisk Investigational Site
| Warszawa, 04-628, Poland
Recruiting
Novo Nordisk Investigational Site
| Warszawa, 04-628, Poland
Not yet recruiting
Novo Nordisk Investigational Site
| Wroclaw, 51-162, Poland
Not yet recruiting
Novo Nordisk Investigational Site
| Zamosc, 22-400, Poland
Recruiting
Novo Nordisk Investigational Site
| Almada, 2805-267, Portugal
Not yet recruiting
Novo Nordisk Investigational Site
| Aveiro, 3814-501, Portugal
Not yet recruiting
Novo Nordisk Investigational Site
| Matosinhos, 4464-513, Portugal
Not yet recruiting
Novo Nordisk Investigational Site
| Novosibirsk, 630099, Russian Federation
Recruiting
Novo Nordisk Investigational Site
| Sochi, 354057, Russian Federation
Not yet recruiting
Novo Nordisk Investigational Site
| Bratislava, 81369, Slovakia
Recruiting
Novo Nordisk Investigational Site
| Bratislava, 83305, Slovakia
Not yet recruiting
Novo Nordisk Investigational Site
| Kosice, 040 01, Slovakia
Recruiting
Novo Nordisk Investigational Site
| Lubochna, 03491, Slovakia
Recruiting
Novo Nordisk Investigational Site
| Martin, 036 59, Slovakia
Suspended
Novo Nordisk Investigational Site
| Presov, 08-181, Slovakia
Not yet recruiting
Novo Nordisk Investigational Site
| Bloemfontein, Free State, 9301, South Africa
Not yet recruiting
Novo Nordisk Investigational Site
| Bloemfontein, Free State, 9301, South Africa
Recruiting
Novo Nordisk Investigational Site
| Centurion, Gauteng, 0157, South Africa
Recruiting
Novo Nordisk Investigational Site
| Johannesburg, Gauteng, 2013, South Africa
Not yet recruiting
Novo Nordisk Investigational Site
| Johannesburg, Gauteng, 2157, South Africa
Suspended
Novo Nordisk Investigational Site
| Johannesburg, Gauteng, 2193, South Africa
Recruiting
Novo Nordisk Investigational Site
| Pretoria, Gauteng, 0183, South Africa
Not yet recruiting
Novo Nordisk Investigational Site
| Pretoria, Gauteng, 0184, South Africa
Recruiting
Novo Nordisk Investigational Site
| Pretoria, Gauteng, 0186, South Africa
Not yet recruiting
Novo Nordisk Investigational Site
| Cape Town, Western Cape, 7130, South Africa
Recruiting
Novo Nordisk Investigational Site
| Cape Town, Western Cape, 7130, South Africa
Not yet recruiting
Novo Nordisk Investigational Site
| Cape Town, Western Cape, 7500, South Africa
Recruiting
Novo Nordisk Investigational Site
| Paarl, Western Cape, 7646, South Africa
Recruiting
Novo Nordisk Investigational Site
| Baracaldo, 48903, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Córdoba, 14004, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| L' Hospitalet Del Llobregat, 08907, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Sanlúcar de Barrameda, 11540, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Valencia, 46010, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Valencia, 46017, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Zaragoza, 50009, Spain
Not yet recruiting
Novo Nordisk Investigational Site
| Malmö, 205 02, Sweden
Not yet recruiting
Novo Nordisk Investigational Site
| Stockholm, 141 85, Sweden
Not yet recruiting
Novo Nordisk Investigational Site
| Stockholm, 171 64, Sweden
Not yet recruiting
Novo Nordisk Investigational Site
| Hsinchu City, 300, Taiwan
Not yet recruiting
Novo Nordisk Investigational Site
| Tainan City, 704, Taiwan
Not yet recruiting
Novo Nordisk Investigational Site
| Taipei, 100, Taiwan
Not yet recruiting
Novo Nordisk Investigational Site
| Taipei, 112, Taiwan
Recruiting
Novo Nordisk Investigational Site
| Afyon, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Ankara, 06230, Turkey
Recruiting
Novo Nordisk Investigational Site
| Antalya, 07058, Turkey
Recruiting
Novo Nordisk Investigational Site
| Eskisehir, 26040, Turkey
Recruiting
Novo Nordisk Investigational Site
| Istanbul, 34098, Turkey
Recruiting
Novo Nordisk Investigational Site
| Istanbul, 34098, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Istanbul, 34381, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Istanbul, 34668, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Izmir, 35100, Turkey
Recruiting
Novo Nordisk Investigational Site
| Izmir, 35340, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Kahramanmaras, 46040, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Kayseri, 38039, Turkey
Recruiting
Novo Nordisk Investigational Site
| Kocaeli, 41380, Turkey
Recruiting
Novo Nordisk Investigational Site
| Mugla, 48000, Turkey
Not yet recruiting
Novo Nordisk Investigational Site
| Chernivtsi, 58023, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Ivano-Frankivsk, 76008, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kharkiv, 61039, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kharkiv, 61178, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kyiv, 02091, Ukraine
Recruiting
Novo Nordisk Investigational Site
| Kyiv, 02660, Ukraine
Recruiting
Novo Nordisk Investigational Site
| Kyiv, 03037, Ukraine
Recruiting
Novo Nordisk Investigational Site
| Kyiv, 03049, Ukraine
Recruiting
Novo Nordisk Investigational Site
| Kyiv, 03151, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kyiv, 03680, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kyiv, 04050, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Kyiv, 04053, Ukraine
Not yet recruiting
Novo Nordisk Investigational Site
| Zaporizhzhia, 69063, Ukraine