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Исследование сравнения тирзепатида (LY3298176) с дулаглутидом в основных сердечно-сосудистых событиях у пациентов с диабетом 2 типа

Название протокола
Клинические исследование Сахарный диабет 2 типа: Tirzepatide, Дулаглутид - Реестр клинических исследований
Платное
Нет
Дата начала и окончания КИ
2022-02-06 - 2022-02-06
Спонсоры

Ведущий спонсор: Eli Lilly and Company

Источник Eli Lilly and Company
Краткое содержание

Цель исследования - оценить эффективность и безопасность тирзепатида по сравнению с дулаглутидом. у участников с диабетом 2 типа и повышенным риском сердечно-сосудистых заболеваний.
Общий статус Рекрутинг
Дата начала 2020-05-29
Дата завершения 2024-10-17
Дата первичного завершения 2024-10-17
Фаза Фаза 3
Тип исследования Интервенционный
Первичный результат
Мера Временное ограничение
Время до первого наступления смерти от сердечно-сосудистых (СС) причин, инфаркта миокарда (ИМ) или инсульта (MACE-3) Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Вторичный результат
Мера Временное ограничение
Time to Death from Any Cause Randomization up to Study Completion (Approximate Maximum 54 Months)
Время смерти от CV Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Время до первого появления ИМ Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Время до первого появления инсульта Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Время до первого появления расширенного сочетания сердечно-сосудистой смерти, инфаркта миокарда, инсульта, коронарной реваскуляризации или госпитализации по поводу нестабильной стенокардии Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Кумулятивное количество смертей от сердечно-сосудистых заболеваний и общее количество (первых и повторных) случаев сердечной недостаточности, требующих госпитализации и / или посещений срочно по поводу сердечной недостаточности Окончание обучения (приблизительный максимум 54 месяца)
Процент участников с потерей веса более 10% 36 месяцев
Изменение массы тела по сравнению с исходным уровнем Исходный уровень, конец исследования (приблизительный максимум 54 месяца)
Изменение гемоглобина A1c (HbA1c) по сравнению с исходным уровнем Исходный уровень, конец исследования (приблизительный максимум 54 месяца)
Изменение соотношения альбумина в моче и креатинина по сравнению с исходным уровнем Исходный уровень, конец исследования (приблизительный максимум 54 месяца)
Изменение липидов крови по сравнению с исходным уровнем Исходный уровень, конец исследования (приблизительный максимум 54 месяца)
Время до первого появления реваскуляризации Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Время до первой госпитализации из-за нестабильной стенокардии Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Время до первого появления новой или ухудшающейся нефропатии Рандомизация до завершения исследования (приблизительный максимум 54 месяца)
Кумулятивное количество первичных комбинированных событий смерти от сердечно-сосудистых заболеваний и общего (первого и повторного) ИМ и / или инсульта Окончание обучения (приблизительный максимум 54 месяца)
Регистрация 12500
Состояние
  • Сахарный диабет 2 типа
Вмешательство

Тип вмешательства: Drug

Название вмешательства: Tirzepatide

Описание: Administered SC

Этикетка Arm Group: Tirzepatide

Другое имя: LY3298176

Тип вмешательства: Препарат, средство, медикамент

Название вмешательства: Дулаглутид

Описание: Администрируемый SC

Этикетка Arm Group: Дулаглутид

Другое имя: LY2189265

Приемлемость

Критерии:

Критерии включения: - иметь диагноз сахарный диабет 2 типа - Подтверждено атеросклеротическое сердечно-сосудистое заболевание. - HbA1c от ≥7,0% до ≤10,5% - Индекс массы тела (ИМТ) ≥25 килограммов на квадратный метр (кг / м²) Критерий исключения: - За последние 60 дней у вас было серьезное сердечно-сосудистое событие - страдаете сахарным диабетом 1 типа - Имейте в анамнезе тяжелую гипогликемию и / или незнание гипогликемии в течение последнего 6 месяцев - В настоящее время планируют лечение диабетической ретинопатии и / или отека желтого пятна. - В настоящее время планируется реваскуляризация коронарных, сонных или периферических артерий. - Имеют в анамнезе панкреатит - Имеют в анамнезе кетоацидоз или гиперосмолярное состояние / кому - имеют известное клинически значимое нарушение опорожнения желудка, перенесли или в настоящее время планируют любую обструкцию выходного отверстия желудка, перенесли или в настоящее время планирование любой операции обходного желудочного анастомоза (бариатрической) или рестриктивной бариатрической хирургии - Имеют в анамнезе активное или нелеченое злокачественное новообразование или находятся в стадии ремиссии после клинически значимое злокачественное новообразование менее 5 лет - Имеют семейный или личный анамнез медуллярной карциномы щитовидной железы (MTC) или множественные синдром эндокринной неоплазии 2 типа (МЭН-2) - перенесли переливание крови или серьезную кровопотерю в течение 90 дней до скрининга или у вас есть известные гематологические состояния, которые могут помешать измерению HbA1c

Пол:

Все

Минимальный возраст:

40 лет

Максимальный возраст:

Нет данных

Здоровые волонтеры:

Нет
Общий Официальный
Фамилия Роль Присоединение
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Study Director Eli Lilly and Company
Общий контакт

Фамилия: There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or

Телефон: 1-317-615-4559
Расположение <
Объект: Положение дел: Контакт: Исследователь:
University of Alabama at Birmingham Medical Center | Birmingham, Alabama, 35294, United States Recruiting 205-975-9564 Fernando Ovalle Principal Investigator
John Muir Physician Network Clinical Research Center | Concord, California, 94520, United States Recruiting 925-687-8860 Anna Chang Principal Investigator
Valley Clinical Trials, Inc. | Covina, California, 91723, United States Recruiting 8182804220 Fahed Georgeos Bitar Principal Investigator
AMCR Institute | Escondido, California, 92025, United States Recruiting 877-567-2627 Timothy S. Bailey Principal Investigator
Valley Endocrine, Fresno | Fresno, California, 93720, United States Recruiting 5592610992 Paul Carlton Norwood Principal Investigator
Marin Endocrine Care & Research, Inc. | Greenbrae, California, 94904, United States Recruiting 415-461-9113 Linda Gaudiani Principal Investigator
UCSD Clinical & Translational Research Institute | La Jolla, California, 92037, United States Recruiting 858-246-2160 Schafer Boeder Principal Investigator
Diabetes and Endocrine Associates | La Mesa, California, 91942, United States Recruiting 6194664899 Raymond Irwin Fink Principal Investigator
First Valley Medical Group | Lancaster, California, 93534, United States Recruiting 646-642-6189 Kanagaratnam Sivalingam Principal Investigator
Monterey Endocrine & Diabetes Institute, Inc. | Monterey, California, 93940, United States Recruiting 831-375-6334 James W Chu Principal Investigator
Riverside County Regional Medical Center | Moreno Valley, California, 92555, United States Recruiting 951-486-2671 Anthony Firek Principal Investigator
Valley Clinical Trials, Inc. | Northridge, California, 91325, United States Recruiting 818-280-4220 Christopher Chow Principal Investigator
Diabetes Associates Medical Group | Orange, California, 92868, United States Recruiting 714-202-8894 Ivy-Joan Madu Principal Investigator
Pasadena Clinical Research | Pasadena, California, 91105, United States Recruiting 6265984952 Fahed Georgeos Bitar Principal Investigator
LCGK Research | San Carlos, California, 94070, United States Recruiting 650-591-9933 Leila Chaychi Principal Investigator
NorCal Endocrinology and Internal Medicine - Roseville | San Ramon, California, 94583, United States Recruiting 916-966-5404 Yshay Shlesinger Principal Investigator
Harbor UCLA Medical Center | Torrance, California, 90502, United States Recruiting 310-781-3622 William J French Principal Investigator
Coastal Metabolic Research Centre | Ventura, California, 93003, United States Recruiting 805-658-8460 Ronald Chochinov Principal Investigator
University of Colorado | Aurora, Colorado, 80045, United States Recruiting 720-848-7174 Neda Rasouli Principal Investigator
CMR of Greater New Haven | Hamden, Connecticut, 06517, United States Recruiting 203-419-4420 Joseph Soufer Principal Investigator
Chase Medical Research, LLC | Waterbury, Connecticut, 06708, United States Recruiting 203-419-4420 Joseph Soufer Principal Investigator
Orlando Heart & Vascular Institute, LLC | Altamonte Springs, Florida, 32714, United States Recruiting 407-767-8554 Nadakishore Ranadive Principal Investigator
Excel Medical Clinical Trials | Boca Raton, Florida, 33434, United States Recruiting 561-488-5535 Seth J. Baum Principal Investigator
Encore Medical Research | Hollywood, Florida, 33021, United States Recruiting 954-400-1725 Rodolfo Perez Principal Investigator
East Coast Institute for Research at The Jones Center | Jacksonville, Florida, 32204, United States Recruiting 904-384-2240 Mae Sheikh-Ali Principal Investigator
Jacksonville Center for Clinical Research | Jacksonville, Florida, 32216, United States Recruiting 904-730-0101 Michael J. Koren Principal Investigator
Ocala Cardiovascular Research | Ocala, Florida, 34471, United States Recruiting 352-873-9557 Lan Luo Principal Investigator
Cardiology Partners Clinical Research Institute, LLC-Palm Beach Gardens | Palm Beach Gardens, Florida, 33410, United States Recruiting 561-537-4778 Amarnath R Vedere Principal Investigator
Charlotte Heart & Vascular Institute | Port Charlotte, Florida, 33952, United States Recruiting 941-629-5356 David A. Hotchkiss Principal Investigator
Meridien Research | Saint Petersburg, Florida, 33709, United States Recruiting 727-347-8839 Gigi C Lefebvre Principal Investigator
Professional Health Care of Pinellas | Saint Petersburg, Florida, 33713, United States Recruiting 727-820-1033 Fadi Saba Principal Investigator
Cardiology Partners Clinical Research Institute, LLC | Wellington, Florida, 33449, United States Recruiting 561-537-4778 Jean Foucauld Principal Investigator
Clinical Research of Central Florida | Winter Haven, Florida, 33880, United States Recruiting 863-293-1191 Robinson N Koilpillai Principal Investigator
Ellipsis Group | Alpharetta, Georgia, 30022, United States Recruiting 404-596-5542 Winston Gandy Principal Investigator
Atlanta Diabetes Associates | Atlanta, Georgia, 30318, United States Recruiting 404-355-4393 Bruce Bode Principal Investigator
Kaiser Permanente - Dutluth, GA | Duluth, Georgia, 30096, United States Recruiting 770-931-6094 Joshua Barzilay Principal Investigator
NSC Research | Johns Creek, Georgia, 30024, United States Recruiting 678-679-1065 Narendra Singh Principal Investigator
Physicians Research Associates, LLC | Lawrenceville, Georgia, 30046, United States Recruiting 6782522375 Adeniyi Olabiyi Odugbesan Principal Investigator
East Coast Institute for Research at The Jones Center | Macon, Georgia, 31210, United States Recruiting 4787468626 Thomas Cunningham Jones Principal Investigator
Atlanta Heart Specialists | Tucker, Georgia, 30084, United States Recruiting 770-407-6369 David D Suh Principal Investigator
East-West Medical Research Institute | Honolulu, Hawaii, 96814, United States Recruiting 808-531-6886 David Fitz-Patrick Principal Investigator
PHREI - Pacific Health Research and Education Institute - VA Pacific Islands Health Care System | Honolulu, Hawaii, 96819, United States Recruiting 808-524-4411 Helen Petrovitch Principal Investigator
Elite Clinical Trials | Blackfoot, Idaho, 83221, United States Recruiting 208-643-0006 Gary W Soucie Principal Investigator
Rocky Mountain Clinical Research | Idaho Falls, Idaho, 83404, United States Recruiting 208-528-9646 Carl D Vance Principal Investigator
Idaho State University | Pocatello, Idaho, 83201, United States Recruiting 208-282-4176 Ronald Solbrig Principal Investigator
Northwest Heart Clinical Research | Arlington Heights, Illinois, 60005, United States Recruiting 847-483-0690 Steven D Lupovitch Principal Investigator
Cedar-Crosse Research Center | Chicago, Illinois, 60607, United States Recruiting 312-431-6780 Danny H Sugimoto Principal Investigator
Clinical Investigation Specialists Inc | Gurnee, Illinois, 60031, United States Recruiting 847-599-2492 Luis Gonzalez Principal Investigator
Springfield Diabetes & Endocrine Center | Springfield, Illinois, 62711, United States Recruiting 217-787-8870 Diana Widicus Principal Investigator
University of Iowa Hospital & Clinic | Iowa City, Iowa, 52242, United States Recruiting 319-356-2838 Marcelo Correia Principal Investigator
Iowa Diabetes and Endocrinology Research Center | West Des Moines, Iowa, 50265, United States Recruiting 515-329-6800 Anuj Bhargava Principal Investigator
University of Kansas Medical Center | Kansas City, Kansas, 66160, United States Recruiting 913-588-2097 David Robbins Principal Investigator
Cotton O'Neil Clinic | Topeka, Kansas, 66606, United States Recruiting 785-368-0744 Scott M. Teeter Principal Investigator
Cotton O'Neil Diabetes and Endocrinology Center | Topeka, Kansas, 66606, United States Recruiting 7853680490 Alan Glenn Wynne Principal Investigator
Qualmedica Research, LLC | Bowling Green, Kentucky, 42101, United States Recruiting 270-685-4589 Christopher Sartore Principal Investigator
L-MARC Research Center | Louisville, Kentucky, 40213, United States Recruiting 502-214-3905 Harold E. Bays Principal Investigator
Qualmedica Research, LLC | Owensboro, Kentucky, 42301, United States Recruiting 270-685-4589 Christopher Sartore Principal Investigator
Maryland Cardiovascular Specialists | Baltimore, Maryland, 21229, United States Recruiting 443-798-2670 Carlos S Ince Principal Investigator
MedStar Health Research Institute | Hyattsville, Maryland, 20782, United States Recruiting 3015602925 Jean Young Park Principal Investigator
Ong Medical Center | Oxon Hill, Maryland, 20745, United States Recruiting 301-839-2916 Stephen Ong Principal Investigator
Endocrine and Metabolic Consultants | Rockville, Maryland, 20852, United States Recruiting 301-770-7373 Helena W. Rodbard Principal Investigator
Brigham and Women's Hospital | Boston, Massachusetts, 02115, United States Recruiting 617-732-5661 Vanita Aroda Principal Investigator
Joslin Diabetes Center | Boston, Massachusetts, 02215, United States Recruiting 617-309-4426 Osama Hamdy Principal Investigator
ActivMed Practices and Research | Methuen, Massachusetts, 01844, United States Recruiting 978-655-7155 Michael J. McCartney Principal Investigator
Infinity Medical Research | North Dartmouth, Massachusetts, 02747, United States Recruiting 508-998-3041 Curtis Mello Principal Investigator
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy, Michigan, 48098, United States Recruiting 248-312-0025 Neil J. Fraser Principal Investigator
St. John's Hospital | Edina, Minnesota, 55435, United States Recruiting 952-836-3546 Les Forgosh Principal Investigator
HealthEast Medical Research Institute | Maplewood, Minnesota, 55109, United States Recruiting 651-471-2651 Les Forgosh Principal Investigator
St Cloud Hospital/Central Minnesota Heart Center | Saint Cloud, Minnesota, 56303, United States Recruiting 320-656-7020 Timothy N Schuchard Principal Investigator
StudyMetrix Research | Saint Peters, Missouri, 63303, United States Recruiting 636-387-5100 Timothy R Smith Principal Investigator
Mercy Research - Smith Glynn Callaway | Springfield, Missouri, 65807, United States Recruiting 417-841-0242 Gregory Ledger Principal Investigator
Clinvest Research LLC | Springfield, Missouri, 65810, United States Recruiting 4178837889 David Gregory True Principal Investigator
Billings Clinic | Billings, Montana, 59101, United States Recruiting 406-435-8470 Haleigh James Principal Investigator
Mercury Street Medical Group, PLLC | Butte, Montana, 59701, United States Recruiting 406-723-1375 John Pullman Principal Investigator
Omaha VA Medical Center | Omaha, Nebraska, 68105, United States Recruiting 402-995-4045 Robert L Anderson Principal Investigator
University of Nebraska Medical Center | Omaha, Nebraska, 68198, United States Recruiting 402-559-5082 Vijay Shivaswamy Principal Investigator
Palm Research Center Tenaya | Las Vegas, Nevada, 89128, United States Recruiting 702-826-2795 Samer Nakhle Principal Investigator
Palm Research Center Tenaya | Las Vegas, Nevada, 89148, United States Recruiting 702-736-5161 Betsy Palal Principal Investigator
Southern Nh Diabetes and Endocrinology | Nashua, New Hampshire, 03060, United States Recruiting 6035777574 Robert Jeffrey Silver Principal Investigator
Cardiovascular Associates of the Delaware Valley | Haddon Heights, New Jersey, 08035, United States Recruiting 856-582-2000 Sanford Gips Principal Investigator
Albany Medical College | Albany, New York, 12203, United States Recruiting 518-461-9734 Robert Busch Principal Investigator
Great Lakes Medical Research | Westfield, New York, 14787, United States Recruiting 716-326-4890 Donald F Brautigam Principal Investigator
Atrium Health - Department of Family Medicine Research | Charlotte, North Carolina, 28207, United States Recruiting 704-304-7178 Jewell Carr Principal Investigator
Duke University Medical Center | Durham, North Carolina, 27710, United States Recruiting 919-668-1220 Jennifer Rowell Principal Investigator
PMG Research Mooresville, LLC | Mooresville, North Carolina, 28117, United States Recruiting 704-924-2105 Timothy Barker Principal Investigator
PMG Research of Wilmington | Wilmington, North Carolina, 28401, United States Recruiting 9108156108 John Charles Parker Principal Investigator
Lillestol Research LLC | Fargo, North Dakota, 58104, United States Recruiting 701-232-7705 Michael J Lillestol Principal Investigator
Cleveland Clinic Foundation | Cleveland, Ohio, 44195, United States Recruiting 216-444-3267 Kevin Pantalone Principal Investigator
Intend Research, LLC | Norman, Oklahoma, 73069, United States Recruiting 405-701-8999 Lisa Connery Principal Investigator
Heritage Valley Medical Group, Inc. | Beaver, Pennsylvania, 15009, United States Recruiting 724-774-7743 Michael J Oliver Principal Investigator
Capital Area Research, LLC | Camp Hill, Pennsylvania, 17011, United States Recruiting 717-963-8389 Venkatesh K Nadar Principal Investigator
Diabetes & Endocrinology Consultants of Pennsylvania, LLC | Feasterville, Pennsylvania, 19053, United States Recruiting 215-953-6804 Arvind R Cavale Principal Investigator
Detweiler Family Medicine & Associates | Lansdale, Pennsylvania, 19446, United States Recruiting 215-368-1900 Robert Detweiler Principal Investigator
Thomas Jefferson University | Philadelphia, Pennsylvania, 19107, United States Recruiting 215-955-1979 Serge Jabbour Principal Investigator
Northeast Endocrine Metabolic Associates | Philadelphia, Pennsylvania, 19114, United States Recruiting 215-969-9511 Mihaela Biscoveanu Principal Investigator
Preferred Primary Care Physicians | Pittsburgh, Pennsylvania, 15236, United States Recruiting 412-650-5623 Bryce A. Palchick Principal Investigator
Cardiology Consultants of Philadelphia | Yardley, Pennsylvania, 19067, United States Recruiting 215-321-7400 Paul Grena Principal Investigator
Ralph H Johnson VA Med Ctr | Charleston, South Carolina, 29401-5703, United States Recruiting 803-577-5011 Kathie L Hermayer Principal Investigator
Tribe Clinical Research, LLC | Greenville, South Carolina, 29607, United States Recruiting 8643340141 Ronald Keith Mayfield Principal Investigator
PMG Research of Charleston, LLC | Mount Pleasant, South Carolina, 29464, United States Recruiting 843-849-1880 Richard Mills Principal Investigator
Black Hills Cardiovascular Research Group | Rapid City, South Dakota, 57701, United States Recruiting 605-718-2610 Sonalika Khachikian Principal Investigator
Holston Medical Group | Bristol, Tennessee, 37620, United States Recruiting 4238572789 Rick James Whiles Principal Investigator
PMG Research of Knoxville | Knoxville, Tennessee, 37938, United States Recruiting 865-244-4276 Rickey Manning Principal Investigator
Endocrine Clinic | Memphis, Tennessee, 38119, United States Recruiting 9017633636 Alan Jay Cohen Principal Investigator
Office of Dr. Osvaldo Brusco | Corpus Christi, Texas, 78414, United States Recruiting 361-885-0790 Osvaldo A Brusco Principal Investigator
Dallas Diabetes Research Center | Dallas, Texas, 75230, United States Recruiting 972-566-7799 Julio Rosenstock Principal Investigator
Cardiovascular Research Institute of Dallas | Dallas, Texas, 75231, United States Recruiting 214-345-4387 Martin R Berk Principal Investigator
North Texas Endocrine Center | Dallas, Texas, 75231, United States Recruiting 4693646918 Peter Edward Bressler Principal Investigator
Research Institute of Dallas | Dallas, Texas, 75231, United States Recruiting 214-265-2145 Stephen Aronoff Principal Investigator
Galenos Research | Dallas, Texas, 75251, United States Recruiting 972-233-5410 Rafael Canadas Principal Investigator
Academy Of Diabetes Thyroid & Endocrine | El Paso, Texas, 79935, United States Recruiting 915-633-9387 Sergio F Rovner Principal Investigator
Diabetes and Thyroid Center of Fort Worth | Fort Worth, Texas, 76132, United States Recruiting 817-644-3815 Anjanette Tan Principal Investigator
Horizon Clinical Research Group | Houston, Texas, 77070, United States Recruiting 281-469-8007 Aditya K. Samal Principal Investigator
Southern Endocrinology Associates | Mesquite, Texas, 75149, United States Recruiting 214-909-8903 Sumana Gangi Principal Investigator
North Hills Medical Research | North Richland Hills, Texas, 76180, United States Recruiting 817-595-3399 John Gabriel Principal Investigator
South Texas Veterans Administration Health Care | San Antonio, Texas, 78229, United States Recruiting 210-949-3933 Devjit Tripathy Principal Investigator
Consano Clinical Research, LLC | Shavano Park, Texas, 78231, United States Recruiting 210-896-7772 Michelle Welch Principal Investigator
Northwest Houston Heart Center | Tomball, Texas, 77375-4536, United States Recruiting 281-351-4911 Shamaila Aslam Principal Investigator
Physicians' Research Options, LLC | Draper, Utah, 84020, United States Recruiting 801-352-9228 David Jack Principal Investigator
Advanced Research Institute | Ogden, Utah, 84405, United States Recruiting 801-409-2040 Michael D. Woolman Principal Investigator
Kalo Clinical Research | Salt Lake City, Utah, 84102, United States Recruiting 801-363-7353 Wobo Bekwelem Principal Investigator
Wasatch Clinical Research, LLC | Salt Lake City, Utah, 84107, United States Recruiting 8012880607 Mara Lee Rabin Principal Investigator
Virginia Heart | Falls Church, Virginia, 22042, United States Recruiting 703-573-3494 Tariq M Haddad Principal Investigator
VA Puget Sound Health Care System | Seattle, Washington, 98108, United States Recruiting 206-764-2788 KRISTINA UTZSCHNEIDER Principal Investigator
Rockwood Clinic Research Center | Spokane, Washington, 99202, United States Recruiting 509-342-3773 Carol H Wysham Principal Investigator
MultiCare Good Samaritan Hospital | Tacoma, Washington, 98405, United States Recruiting 253-697-4192 Ahmad Slim Principal Investigator
Wenatchee Valley Hospital & Clinics | Wenatchee, Washington, 98801, United States Recruiting 509-665-5800 Steven R Kaster Principal Investigator
Clinical Investigation Specialists Inc | Kenosha, Wisconsin, 53144, United States Recruiting 262-925-1280 John M Agaiby Principal Investigator
Instituto de Investigaciones Clínicas Bahia Blanca | Bahía Blanca, Buenos Aires, B8000, Argentina Recruiting 542914521482 Andrea Dominguez Principal Investigator
Centro OMI | Caba, Buenos Aires, C1015ABO, Argentina Recruiting 541143720308 Diego Alberto Carrozza Principal Investigator
CEDIC | Caba, Buenos Aires, C1060ABN, Argentina Recruiting 541148238701 Elizabeth Gelersztein Principal Investigator
Mautalen Salud e Investigación | Caba, Buenos Aires, C1128AAF, Argentina Recruiting 541145143406 José Osvaldo Fretes Principal Investigator
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada | Caba, Buenos Aires, C1425AGC, Argentina Recruiting +541148019001 Sonia Angelica Sassone Principal Investigator
Glenny Corp SA- BIOCLINICA Argentina | Caba, Buenos Aires, C1430CKE, Argentina Recruiting 541145445522 Martin Horacio Koretzky Principal Investigator
Stat Research S.A. | Capital Federal, Buenos Aires, 1023, Argentina Recruiting 541148166733 Lucas Lisandro Lisandro Gutnisky Principal Investigator
Centro de Investigaciones Metabólicas (CINME) | Ciudad Autónoma de Buenos Aire, Buenos Aires, 1056, Argentina Recruiting 541150319914 Maria Alejandra Romeo Principal Investigator
Instituto de Investigaciones Clínicas Mar del Plata | Mar del Plata, Buenos Aires, B7600FZN, Argentina Recruiting 542234963224 Ignacio MacKinnon Principal Investigator
DIM Clinica Privada | Ramos Mejía, Buenos Aires, 1704, Argentina Recruiting 541146562828 Oscar Romano Montana Principal Investigator
Instituto de Investigaciones Clínicas Rosario (IIC-Rosario)- Sanatorio Delta | Rosario, Buenos Aires, S2000BIF, Argentina Recruiting 543414473997 Maximiliano Sicer Principal Investigator
Go Centro Medico San Nicolás | San Nicolás, Buenos Aires, B2900DPA, Argentina Recruiting 5403364420980 Paulina Virginia Lanchiotti Principal Investigator
Instituto de Investigaciones Clinicas Zarate | Zárate, Buenos Aires, 2800, Argentina Recruiting +54 348 7431654 Marisa Liliana Vico Principal Investigator
Centro Médico Viamonte | Buenos Aires, Ciudad Autónoma De Buenos Aire, C1120AAC, Argentina Recruiting 541149635650 Diego Aizenberg Principal Investigator
CEMEDIAB | C.a.b.a., Ciudad Autónoma De Buenos Aire, C1205AAO, Argentina Recruiting 541149815688 Alejandro Chertkoff Principal Investigator
CIPREC | Ciudad Autonoma de Buenos Aire, Ciudad Autónoma De Buenos Aire, C1119ACN, Argentina Recruiting +5411 4827-3866 Cesar Javier Zaidman Principal Investigator
Centro Medico Privado San Vicente Diabetes | Cordoba, Córdoba, 5006, Argentina Recruiting 543514558041 Andrea Steinacher Principal Investigator
Instituto Médico Catamarca | Rosario, Santa Fe, 2000, Argentina Recruiting 543412985581 Natacha Maldonado Principal Investigator
Grupo Colaborativo Rosario | Rosario, Santa Fe, S2002OJN, Argentina Recruiting 543414393644 Horacio Sessa Principal Investigator
Centro de Investigaciones Médicas Tucuman | SAN M. DE Tucuman, Tucumán, T4000AXL, Argentina Recruiting 543814200180 Leonardo Pablo Serra Principal Investigator
Investigaciones Clínicas Tucumán | San Miguel de Tucuman, TUC, T4000NIL, Argentina Recruiting 543814210815 Aldo Prado Principal Investigator
CEMEDIC | Buenos Aires, 1407, Argentina Recruiting 541146356624 Claudio R. Majul Principal Investigator
Asociación de Beneficencia Hospital Sirio Libanés | Buenos Aires, C1419AHN, Argentina Recruiting 541145740870 Gustavo Daniel Frechtel Principal Investigator
CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani | Cordoba, 5000, Argentina Recruiting 543514681516 Maria Rosa Ulla Principal Investigator
Cent Priva Especiali Médicas Ambulatorias Inve Clin CEMAIC | Cordoba, X5008HHW, Argentina Recruiting 5403514766837 Lucrecia Nardone Principal Investigator
Centro Universitario de Investigaciones en Farmacologia Clinica (CUIFC) | Corrientes, 3400, Argentina Recruiting 543794474180 Silvia Lapertosa Principal Investigator
Instituto de Cardiologia de Corrientes | Corrientes, 3400, Argentina Recruiting 543794410000 Julio Andres Vallejos Principal Investigator
Centro Diabetológico Dr. Waitman | Córdoba, 5000, Argentina Recruiting 543514245162 Jorge Waitman Principal Investigator
Sanatorio Parque | Salta, 4400, Argentina Recruiting 543874318800 Silvia Saavedra Principal Investigator
Sanatorio Norte | Santiago del Estero, 4200, Argentina Recruiting 0385 4224722/ 4999 Franklin Hector Abalos Principal Investigator
Clínica Mayo | Tucuman, T4000IHE, Argentina Recruiting 543814265000 Maria Eugenia Valdez Principal Investigator
Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders | Camperdown, New South Wales, 2006, Australia Recruiting 61286271944 Ian Caterson Principal Investigator
Nepean Family Metabolic Health Service | Kingswood, New South Wales, 2747, Australia Recruiting 61247344533 Kathryn Williams Principal Investigator
The AIM Centre / Hunter Diabetes Centre | Merewether, New South Wales, 2291, Australia Recruiting 61249576754 Claire Morbey Principal Investigator
Illawarra Shoalhaven Local Health District | Wollongong, New South Wales, 2500, Australia Recruiting 61242311950 Alexia Pape Principal Investigator
Core Research Group | Brisbane, Queensland, 4064, Australia Recruiting 61733719477 David Martin Colquhoun Principal Investigator
The Townsville Hospital | Douglas, Queensland, 4814, Australia Recruiting 61744331111 Kunwarjit Sangla Principal Investigator
Royal Brisbane and Womens Hospital | Herston, Queensland, 4029, Australia Recruiting 61736467780 Michael D'Emden Principal Investigator
Mater Adult Hospital Brisbane | South Brisbane, Queensland, 4700, Australia Recruiting 61734638111 Helen Barrett Principal Investigator
Gold Coast University Hospital | Southport, Queensland, 4215, Australia Recruiting 61755198211 Atifur Rahman Principal Investigator
Heart and Vascular Institute | Adelaide, South Australia, 5000, Australia Recruiting 61874444219 Andrew Hamilton Principal Investigator
Royal Adelaide Hospital | Adelaide, South Australia, 5000, Australia Recruiting 61871172231 Matthew Worthley Principal Investigator
Southern Adelaide Diabetes & Endocrine Services | Oaklands Park, South Australia, 5046, Australia Recruiting 610874258690 Stephen Neil Stranks Principal Investigator
Launceston General Hospital | Launceston, Tasmania, 7250, Australia Recruiting 61367776960 Duncan Cooke Principal Investigator
Box Hill Hospital Outpatients | Box Hill, Victoria, 3128, Australia Recruiting 61390949508 Christopher Gilfillan Principal Investigator
Monash Cardiovascular Research Centre | Clayton, Victoria, 3168, Australia Recruiting 61395944507 Stephen Nicholls Principal Investigator
Barwon Health - The Geelong Hospital | Geelong, Victoria, 3220, Australia Recruiting 61342152875 Shannon McCarthy Principal Investigator
Austin Health - Heidelberg Repatriation Hospital | Heidelberg Heights, Victoria, 3081, Australia Recruiting 61404488958 Elif Ekinci Principal Investigator
School of Medicine, Fremantle Hospital | Fremantle, Western Australia, 6160, Australia Recruiting 61894313228 Timothy Mark Davis Principal Investigator
GenesisCare - Wexford Medical Centre WA | Murdoch, Western Australia, 6150, Australia Recruiting 61894006118 Peter Walter Purnell Principal Investigator
GenesisCare - Shenton House | Joondalup, 6027, Australia Recruiting 61894006118 Peter Walter Purnell Principal Investigator
Universitätsklinikum Graz | Graz, Steiermark, 8036, Austria Recruiting 4331638581310 Harald Sourij Principal Investigator
Universitätsklinikum Salzburg | Salzburg, 5020, Austria Recruiting 43 57255 57345 Lars Stechemesser Principal Investigator
Klinik Landstraße | Wien, 1030, Austria Recruiting 431711652101 Bernhard Ludvik Principal Investigator
Zentrum für klinische Studien Dr Hanusch Gmbh | Wien, 1060, Austria Recruiting 436763872281 Ursula Hanusch Principal Investigator
AKH | Wien, 1090, Austria Recruiting 431404000 Alexandra Kautzky-Willer Principal Investigator
Krankenhaus Hietzing | Wien, 1130, Austria Recruiting 431801102351 Thomas Stulnig Principal Investigator
Imelda General Hospital | Bonheiden, Antwerpen, 2820, Belgium Recruiting 015504706 Chris Vercammen Principal Investigator
AZ Klina | Brasschaat, Antwerp, 2930, Belgium Recruiting 03 650 52 88 Frank Cools Principal Investigator
Onze Lieve Vrouw Ziekenhuis Aalst | Aalst, Oost-Vlaanderen, 9300, Belgium Recruiting 32053724488 Frank NOBELS Principal Investigator
AZ Nikolaas, Campus Moerland | Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium Recruiting 003237602181 Peter Ernest Coremans Principal Investigator
ZNA Jan Palfijn | Merksem, Vlaams Gewest, 2170, Belgium Recruiting 3236402111 Ann Verhaegen Principal Investigator
AZ Delta | Roeselare, West Flanders, 8800, Belgium Recruiting 3251237430 Francis Duyck Principal Investigator
AZ Sint-Jan AV | Brugge, 8000, Belgium Recruiting 050452330 Youri Taes Principal Investigator
ULB Erasme | Brussels, 1070, Belgium Recruiting +3225555377 Laurent Crenier Principal Investigator
Universitair Ziekenhuis Antwerpen | Edegem, 2650, Belgium Recruiting 003238254980 Christophe De Block Principal Investigator
UZ Brussel | Jette, 1090, Belgium Recruiting 0032 02 477 77 60 Corinne Debroye Principal Investigator
AZ Groeninge | Kortrijk, 8500, Belgium Recruiting 003256633188 Gerd Vanhaverbeke Principal Investigator
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven, 3000, Belgium Recruiting 3216341579 Ann Mertens Principal Investigator
CHU de Liège | Liege, 4000, Belgium Recruiting (324) 366-7237 Regis Radermecker Principal Investigator
AZ Damiaan Oostende | Oostende, 8400, Belgium Recruiting 059414166 Linsey Winne Principal Investigator
Centro de Pesq. em Diabetes e Doencas Endocrino Metabol. | Fortaleza, Ceará, 60430-350, Brazil Recruiting 558530327044 Viviane Rocha Nasser Hissa Principal Investigator
CEDOES | Vitoria, ES, 29055-450, Brazil Recruiting 552721250220 queulla garret santos Principal Investigator
QUANTA - Medicina Nuclear Alto da XV | Curitiba, Paraná, 80045-170, Brazil Recruiting 554132628040 Rosangela Rea Principal Investigator
Centro de Pesquisas em Diabetes | Porto Alegre, Rio Grande Do Sul, 90430-001, Brazil Recruiting 555132684276 Luis Henrique Canani Principal Investigator
CPCLIN | São Paulo, SP, 01228-200, Brazil Recruiting 551127110251 Denise Reis Franco Principal Investigator
Hospital da Clinicas da Faculdade de Medicina da USP | São Paulo, SP, 05403-000, Brazil Recruiting 551126617846 Cintia Cercato Principal Investigator
Loema Instituto de Pesquisa Clinica | Campinas, São Paulo, 13010-001, Brazil Recruiting 551932670023 Maria Helena Vidotti Principal Investigator
IPECC - Instituto de Pesquisa Clinica de Campinas | Campinas, São Paulo, 13060-080, Brazil Recruiting 551932670023 Jose Francisco Kerr Saraiva Principal Investigator
CECIP - Centro de Estudos do Interior Paulista | Jaú, São Paulo, 17201-130, Brazil Recruiting 5514981169078 Gabriela Romano Oliveira Principal Investigator
Faculdade de Medicina do ABC | Santo André, São Paulo, 09060-870, Brazil Recruiting 551149935459 Augusto Cesar Santomauro Junior Principal Investigator
ISPEM - Instituto São José dos Campos em Pesquisas Médicas | São José dos Campos, São Paulo, 12243-280, Brazil Recruiting 551239131789 Márcio Antonio Pereira Principal Investigator
Instituto Brasil de Pesquisa Clínica - IBPCLIN | Rio de Janeiro, 20241180, Brazil Recruiting 552125277979 Luis Augusto Tavares Russo Principal Investigator
IPEC - Instituto de Pesquisa Clínica | São Paulo, 01223-001, Brazil Recruiting 551127370277 Joao Eduardo Nunes Salles Principal Investigator
CPQuali Pesquisa Clínica | São Paulo, 01228-000, Brazil Recruiting 551127766801 Gustavo Akerman Akerman Augusto Principal Investigator
CEPIC - Centro Paulista de Investigação Clínica | São Paulo, 04266-010, Brazil Recruiting 551122713450 Breno Balabem Alves Principal Investigator
LMC Diabetes & Endocrinology | Calgary, Alberta, T2H 2G4, Canada Recruiting 4032883224 Buki Ajala Principal Investigator
Dr. T.G. Elliott, Inc. | Vancouver, British Columbia, V5Y 3W2, Canada Recruiting 6046833734 Thomas G Elliott Principal Investigator
Dr. M.B. Jones Inc. | Victoria, British Columbia, V8V 4A1, Canada Recruiting 5814773439 Michael Jones Principal Investigator
Winnipeg Clinic | Winnipeg, Manitoba, R3C 0N2, Canada Recruiting 2049573218 Vincent C Woo Principal Investigator
Queen Elizabeth II Health Sciences Center | Halifax, Nova Scotia, B3H 1V7, Canada Recruiting 9024733712 Churn-Ern Yip Principal Investigator
LMC Clinical Research Inc. (Montreal) | Barrie, Ontario, L4N 7L3, Canada Recruiting 7057370830 Hani Alasaad Principal Investigator
LMC Endocrinology Centers Brampton | Brampton, Ontario, L6S 0C6, Canada Recruiting 9055950560 Harpreet Bajaj Principal Investigator
Aggarwal and Associates Limited | Brampton, Ontario, L6T 0G1, Canada Recruiting 9054589033 Naresh Kumar Aggarwal Principal Investigator
Cambridge Cardiac Care Centre | Cambridge, Ontario, N1R 6V6, Canada Recruiting 5196243511 Shekhar Pandey Principal Investigator
LMC Clinical Research Inc. (Montreal) | Concord, Ontario, L4K 4M2, Canada Recruiting 9057638660 Ronald Goldenberg Principal Investigator
LMC Clinical Research Inc. (Montreal) | Etobicoke, Ontario, M9R 4E1, Canada Recruiting 8667013636 Hasnain L. Khandwala Principal Investigator
Milestone Research Inc. | London, Ontario, N5W 6A2, Canada Recruiting 5196594040 Peter Dzongowski Principal Investigator
St Joseph Health Care | London, Ontario, N6A 4V2, Canada Recruiting 5196466100 Irene Mary Hramiak Principal Investigator
LMC Clinical Research Inc. (Montreal) | Nepean, Ontario, K2J 0V2, Canada Recruiting 6135059704 Chetna Tailor Principal Investigator
North York Diagnostic & Cardiac Centre | North York, Ontario, M6B 3H7, Canada Recruiting 4167109050 Subodh Verma Principal Investigator
LMC Clinical Research Inc. (Oakville) | Oakville, Ontario, L6M 1M1, Canada Recruiting 9053370040 David Twum-Barima Principal Investigator
Private Practice - Dr. James Cha | Oshawa, Ontario, L1J 2K1, Canada Recruiting 9057258632 James Cha Principal Investigator
Kawartha Cardiology Clinical Trials | Peterborough, Ontario, K9J 0B2, Canada Recruiting 7057754278 Michael Hartleib Principal Investigator
Bluewater Clinical Research Group Inc. | Sarnia, Ontario, N7T 4X3, Canada Recruiting 5193446612 John O'Mahony Principal Investigator
Canadian Centre for Research on Diabetes | Smiths Falls, Ontario, K7A 4W8, Canada Recruiting 6132838582 James Robin Conway Principal Investigator
Janik Research Corporation | Sudbury, Ontario, P3B4H5, Canada Recruiting 7054192107 Dinkar Shukla Principal Investigator
Canadian Phase Onward Inc | Toronto, Ontario, M3J 2C5, Canada Recruiting 5142597265 Lew Pliamm Principal Investigator
LMC Clinical Research Inc. (Montreal) | Toronto, Ontario, M4G 3E8, Canada Recruiting 4166452929 Alexandre Abitol Principal Investigator
Diabetes Heart Research Center | Toronto, Ontario, M6G 1M2, Canada Recruiting 14169245871 LUIS NORONHA Principal Investigator
Dr. Anil K. Gupta Medicine Professional Corporation | Toronto, Ontario, M9V 4B4, Canada Recruiting 4167411500 Anil Gupta Principal Investigator
ViaCar Recherche Clinique | Greenfield Park, Quebec, J4V 2G8, Canada Recruiting 4504657252 Raja Chehayeb Principal Investigator
Centre De Recherche Clinique De Laval | Laval, Quebec, H7T 2P5, Canada Recruiting 4506884340 Richard Dumas Principal Investigator
Manna Research | Lévis, Quebec, G6W 0M5, Canada Recruiting 4188398572 Francois Blouin Principal Investigator
Clinique Sante Cardio MC | Montreal, Quebec, H1T 3Y7, Canada Recruiting 5142597265 Christian Constance Principal Investigator
CR A&E Centre de Recherche Inc. | Quebec City, Quebec, G1N 4V3, Canada Recruiting 5814773439 Andre Frechette Principal Investigator
Peking University First Hospital | Beijing, Beijing, 100034, China Active, not recruiting
Peking University People's Hospital | Beijing, Beijing, 100044, China Active, not recruiting
Beijing Friendship Hospital | Beijing, Beijing, 100050, China Active, not recruiting
The First Hospital of Lanzhou University | Lanzhou, Gansu, 730000, China Active, not recruiting
Lanzhou university second hospital | Lanzhou, Gansu, 730030, China Active, not recruiting
The First Affiliated Hospital, Sun-Yat Sen University | Guangzhou, Guangdong, 510080, China Active, not recruiting
The Fourth Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, 150001, China Active, not recruiting
First Huai'an Hospital Affiliated to Nanjing Medical Univers | Huai'an, Jiangsu, 223300, China Active, not recruiting
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School | Nanjing, Jiangsu, 210000, China Active, not recruiting
The First Hospital of Nanjing | Nanjing, Jiangsu, 210006, China Active, not recruiting
Zhongda Hospital Southeast University | Nanjing, Jiangsu, 210009, China Active, not recruiting
The Second Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, 210011, China Active, not recruiting
Affiliated Hospital of Jiangsu University | Zhenjiang, Jiangsu, 212000, China Active, not recruiting
The First Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, China Active, not recruiting
Pingxiang People's Hospital | Pingxiang, Jiangxi, 337055, China Active, not recruiting
China-Japan Union Hospital of Jilin University | Changchun, Jilin, 100853, China Active, not recruiting
The People's Hospital of Liaoning Province | Shenyang, Liaoning, 110016, China Active, not recruiting
General Hospital of Ningxia Medical University | Yinchuan, Ningxia, 750004, China Active, not recruiting
The First Afflicated Hospital of Xian Jiaotong University | Xian, Shan XI, 710061, China Active, not recruiting
Jinan Central Hospital | Jinan, Shandong, 250013, China Active, not recruiting
Tianjin Medical University General Hospital | Tianjin, Tianjin, 300052, China Active, not recruiting
Beijing Anzhen Hospital | Beijing, 100029, China Active, not recruiting
People's Hospital of Hunan Province | Changsha, 410002, China Active, not recruiting
MUDr. Tomas Edelsberger | Krnov, Moravskoslezský Kraj, 79401, Czechia Recruiting 420554611468 Tomas Edelsberger Principal Investigator