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Индукционное исследование мирикизумаба у участников с язвенным колитом средней и тяжелой степени (LUCENT 1)

Название протокола
Клинические исследование Язвенный колит: Mirikizumab, Плацебо - Реестр клинических исследований
Платное
Нет
Дата начала и окончания КИ
2022-02-06 - 2022-02-06
Спонсоры

Ведущий спонсор: Eli Lilly and Company

Источник Eli Lilly and Company
Краткое содержание

Целью данного исследования является оценка безопасности и эффективности мирикизумаба при участники с активным язвенным колитом (ЯК) от умеренной до тяжелой степени, перенесшие неадекватный ответ, потеря ответа или непереносимость традиционной или биологической терапии для УЦ.
Общий статус Рекрутинг
Дата начала 2018-03-15
Дата завершения 2022-10-08
Дата первичного завершения 2021-01-21
Фаза Фаза 3
Тип исследования Интервенционный
Первичный результат
Мера Временное ограничение
Процент участников с клинической ремиссией Неделя 12
Вторичный результат
Мера Временное ограничение
Percentage of Participants in Clinical Response Week 12
Процент участников с эндоскопической ремиссией Неделя 12
Процент участников с симптоматической ремиссией Неделя 12
Процент участников симптоматического ответа Неделя 12
Процент участников с гистологической ремиссией Неделя 12
Процент участников эндоскопического ответа Неделя 12
Изменение симптомов ЯК по сравнению с исходным уровнем на 12-й неделе: числовая шкала оценки (NRS) Исходный уровень, неделя 12
Изменение качества жизни, связанного со здоровьем, по сравнению с 12-й неделей по сравнению с исходным уровнем: опросник по воспалительным заболеваниям кишечника (IBDQ) Исходный уровень, неделя 12
Изменение фекального кальпротектина по сравнению с исходным уровнем на 12-й неделе Исходный уровень, неделя 12
Фармакокинетика (ПК): клиренс Мирикизумаба Недели 0, 4, 8 и 12: предварительная доза; Неделя 0 и 4: до 2 часов после введения дозы
Регистрация 1160
Состояние
  • Язвенный колит
Вмешательство

Тип вмешательства: Drug

Название вмешательства: Mirikizumab

Описание: Administered IV

Этикетка Arm Group: Mirikizumab

Другое имя: LY3074828

Тип вмешательства: Препарат, средство, медикамент

Название вмешательства: Плацебо

Описание: Администрируемый IV

Этикетка Arm Group: Плацебо

Приемлемость

Критерии:

Критерии включения: - Диагноз язвенного колита не менее чем за 3 месяца до исходного уровня. - Подтвержденный диагноз умеренно или тяжело активного ЯК, по оценке модифицированного Оценка Мейо (MMS). - Демонстрировал неадекватную реакцию, потерю реакции или нетерпимость к традиционной или биологической терапии язвенного колита. - Если женщина, должны соответствовать требованиям контрацепции. Критерий исключения: - Участники с текущим диагнозом болезни Крона или воспаления кишечника заболевание неклассифицированное (неопределенный колит). - Участники с предыдущей колэктомией. - Участники с текущими признаками токсического мегаколона. - Предшествующее воздействие антител к IL12p40 (например, устекинумаб) или антител к IL-23p19 антитела (например, рисанкизумаб, бразикумаб, гуселкумаб или тилдракизумаб).

Пол:

Все

Минимальный возраст:

18 лет

Максимальный возраст:

80 лет

Здоровые волонтеры:

Нет
Общий Официальный
Фамилия Роль Присоединение
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Study Director Eli Lilly and Company
Общий контакт

Фамилия: There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or

Телефон: 1-317-615-4559
Расположение
Объект: Положение дел:
Digestive Health Specialists of the Southeast | Dothan, Alabama, 36305, United States Active, not recruiting
Dcr-Pi, Pc | Litchfield Park, Arizona, 85340, United States Active, not recruiting
Maricopa Integrated Health System | Phoenix, Arizona, 85008, United States Active, not recruiting
Physicians Research Group | Tempe, Arizona, 85284, United States Completed
University of Arizona, CATS Research Center | Tucson, Arizona, 85724, United States Active, not recruiting
Yuma Gastro LLC | Yuma, Arizona, 85364, United States Completed
Valley Gastroenterology Cnslts | Arcadia, California, 91006, United States Active, not recruiting
Care Access Research | Berkeley, California, 94705, United States Active, not recruiting
Citrus Valley Health Partners | Covina, California, 91722, United States Completed
Valley View Internal Medicine | Garden Grove, California, 92843, United States Completed
University of California - San Diego | La Jolla, California, 92093, United States Active, not recruiting
Om Research, LLC | Lancaster, California, 93534, United States Active, not recruiting
Catalina Research Institute, LLC | Montclair, California, 91763, United States Completed
California Medical Research Group | Northridge, California, 91324, United States Active, not recruiting
Gastroenterology Associates | Pasadena, California, 91105, United States Completed
Clinical Applications Laboratories, Inc. | San Diego, California, 92103, United States Active, not recruiting
UCSF Medical Center at Mission Bay | San Francisco, California, 94158, United States Active, not recruiting
University of Colorado | Aurora, Colorado, 80045, United States Completed
Delta Waves Sleep Disorders and Research Center | Colorado Springs, Colorado, 80918, United States Completed
Gastro Florida | Clearwater, Florida, 33756, United States Completed
West Central Gastroenterology d/b/a Gastro Florida | Clearwater, Florida, 33761, United States Completed
Clinical Research of West Florida, Inc. (Clearwater) | Clearwater, Florida, 33765, United States Completed
Pioneer Clinical Research | Coral Springs, Florida, 33067, United States Completed
Doral Research Center | Doral, Florida, 33166, United States Active, not recruiting
Direct Helpers Medical Center | Hialeah, Florida, 33012, United States Active, not recruiting
Wellness Clinical Research | Hialeah, Florida, 33012, United States Active, not recruiting
The Center for Gastrointestinal Disorders | Hollywood, Florida, 33021, United States Completed
Nature Coast Clinical Research, LLC | Inverness, Florida, 34452, United States Active, not recruiting
SIH Research, LLC | Kissimmee, Florida, 34741, United States Active, not recruiting
Center for Advanced Gastroenterology, PLLC | Maitland, Florida, 32751, United States Active, not recruiting
Inpatient Research Clinic, LLC | Miami Lakes, Florida, 33014, United States Completed
Life Medical Center & Research, Inc | Miami Lakes, Florida, 33014, United States Active, not recruiting
Columbus Clinical Services, LLC | Miami, Florida, 33125, United States Completed
Research Associates of South Florida, LLC | Miami, Florida, 33134, United States Active, not recruiting
Coral Research Clinic Corp | Miami, Florida, 33186, United States Active, not recruiting
Pharma Research International, Inc. | Naples, Florida, 34110, United States Completed
Center for Interventional Endoscopy | Orlando, Florida, 32804, United States Active, not recruiting
Clintheory Healthcare | Orlando, Florida, 32819, United States Active, not recruiting
IMIC, Inc. | Palmetto Bay, Florida, 33157, United States Completed
Gastroenterology Associates of Pensacola, PA | Pensacola, Florida, 32503, United States Active, not recruiting
Florida Digestive Specialist | Saint Petersburg, Florida, 33709, United States Completed
Florida Medical Clinic LLC | Zephyrhills, Florida, 33542-7505, United States Active, not recruiting
Digestive Healthcare of Georgia | Atlanta, Georgia, 30309, United States Active, not recruiting
Gastrointestinal Diseases Research | Columbus, Georgia, 31904, United States Completed
Atlanta Gastroenterology Specialists, PC | Suwanee, Georgia, 30024, United States Completed
Grand Teton Research Group, PLLC | Idaho Falls, Idaho, 83404, United States Active, not recruiting
NorthShore University HealthSystem | Evanston, Illinois, 60201, United States Active, not recruiting
Lemah Creek Clinical Research | Oakbrook Terrace, Illinois, 60181, United States Active, not recruiting
Indiana University School of Medicine | Indianapolis, Indiana, 46202, United States Active, not recruiting
Iowa Digestive Disease Center | Clive, Iowa, 50325, United States Completed
University of Kansas Medical Center | Kansas City, Kansas, 66160, United States Active, not recruiting
WestGlen GI Consultants | Shawnee Mission, Kansas, 66217, United States Active, not recruiting
Cotton-O'Neil Clinical Research Center, Digestive Health | Topeka, Kansas, 66606, United States Active, not recruiting
Texas Digestive Disease Consultants | Baton Rouge, Louisiana, 70809, United States Active, not recruiting
Clinical Trials of SWLA, LLC | Lake Charles, Louisiana, 70601, United States Completed
Delta Research Partners LLC | Monroe, Louisiana, 71201, United States Active, not recruiting
Tulane Univ School of Med | New Orleans, Louisiana, 70112 2715, United States Completed
Nola Research Works, LLC | New Orleans, Louisiana, 70125, United States Active, not recruiting
University of Maryland Medical Center | Baltimore, Maryland, 21201, United States Active, not recruiting
University of Massachusetts Medical Center | Worcester, Massachusetts, 01655, United States Active, not recruiting
Clinical Research Institute of Michigan, LLC | Chesterfield, Michigan, 48047, United States Active, not recruiting
Henry Ford Health System | Novi, Michigan, 48377, United States Active, not recruiting
Gastroenterology Associates of Western Michigan, P.L.C. | Wyoming, Michigan, 49519, United States Active, not recruiting
Huron Gastroenterology Associates | Ypsilanti, Michigan, 48197, United States Active, not recruiting
Minnesota Gastroenterology, P.A. | Plymouth, Minnesota, 55446, United States Active, not recruiting
Washington University Medical School | Saint Louis, Missouri, 63110, United States Active, not recruiting
Bozeman Health Deaconess Hospital | Bozeman, Montana, 59715, United States Active, not recruiting
Capital Health Medical Center Hopewell | Pennington, New Jersey, 08534, United States Completed
Holy Name Medical Center | Teaneck, New Jersey, 07666, United States Active, not recruiting
Northwell Health | Great Neck, New York, 11021, United States Active, not recruiting
NYU Langone Long Island Clinical Research Associates | Lake Success, New York, 11042, United States Completed
Weill Cornell Medical College | New York, New York, 10021, United States Active, not recruiting
Mount Sinai - PRIME | New York, New York, 10029, United States Active, not recruiting
University of North Carolina | Chapel Hill, North Carolina, 27599, United States Active, not recruiting
Carolina Digestive Diseases | Greenville, North Carolina, 27834, United States Active, not recruiting
Wake Forest University School of Medicine | Winston-Salem, North Carolina, 27157-1045, United States Completed
Mid Dakota Clinic | Bismarck, North Dakota, 58501, United States Active, not recruiting
Trinity Health Center Medical Arts | Minot, North Dakota, 58701, United States Completed
META Medical Research Institute, LLC | Dayton, Ohio, 45432, United States Completed
Paramount Medical Research | Middleburg Heights, Ohio, 44130, United States Active, not recruiting
Care Access Research - Youngstown | Poland, Ohio, 44514, United States Active, not recruiting
Great Lakes Medical Research, LLC | Westlake, Ohio, 44145, United States Completed
Central Sooner Research | Norman, Oklahoma, 73071, United States Active, not recruiting
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, 73104, United States Active, not recruiting
Care Access Research LLC | Pottsville, Pennsylvania, 17901, United States Active, not recruiting
Digestive Disease Associates, Ltd. | Wyomissing, Pennsylvania, 19610, United States Active, not recruiting
Ocean State Clinical Research Partners | Lincoln, Rhode Island, 02865, United States Completed
Invocare Clinical Research Center | Mauldin, South Carolina, 29662, United States Active, not recruiting
Invocare Clinical Research Center | West Columbia, South Carolina, 29169, United States Completed
Midwest Medical Care | Sioux Falls, South Dakota, 57108, United States Active, not recruiting
Gastro One | Germantown, Tennessee, 38138, United States Active, not recruiting
Galen Medical Group | Hixson, Tennessee, 37343, United States Active, not recruiting
Vanderbilt University Medical Center | Nashville, Tennessee, 37232, United States Completed
Doctors Hospital at Renaissance Research Institute | Edinburg, Texas, 78539, United States Active, not recruiting
University of Texas Medical Branch at Galveston | Galveston, Texas, 77555, United States Completed
Digestive Health Associates of Texas | Garland, Texas, 75044, United States Active, not recruiting
Houston Methodist Research Ins | Houston, Texas, 77030, United States Active, not recruiting
Biopharma Informatic, Inc. | Houston, Texas, 77084, United States Active, not recruiting
Gastroenterology Research of San Antonio | San Antonio, Texas, 78229, United States Active, not recruiting
Southern Star Research Institute, LLC | San Antonio, Texas, 78229, United States Active, not recruiting
BFHC Research | San Antonio, Texas, 78249, United States Completed
Texas Digestive Disease Consultants | Southlake, Texas, 76092, United States Active, not recruiting
GI and Liver Research, LLC | Webster, Texas, 77598, United States Completed
Care Access Research LLC - Salt Lake City | Ogden, Utah, 84403, United States Active, not recruiting
Care Access Research LLC - Salt Lake City | Salt Lake City, Utah, 84124, United States Completed
Emeritas Research Group | Leesburg, Virginia, 20176, United States Active, not recruiting
Blue Ridge Medical Research | Lynchburg, Virginia, 24502, United States Completed
Gastroenterology Associates, PC | Manassas, Virginia, 20110, United States Active, not recruiting
The Gastroenterology Group, P.C. | Reston, Virginia, 20191, United States Completed
Carilion Clinic | Roanoke, Virginia, 24016, United States Active, not recruiting
University of Washington Medical Center | Seattle, Washington, 98195-6424, United States Completed
Digestive Health Specialists | Tacoma, Washington, 98405, United States Active, not recruiting
Wisconsin Center for Advanced Research | Milwaukee, Wisconsin, 53215, United States Active, not recruiting
Allegiance Research Specialists, LLC | Milwaukee, Wisconsin, 53226, United States Completed
Centro de Investigaciones Metabólicas (CINME) | Caba, Buenos Aires, C1027AAP, Argentina Active, not recruiting
Mautalen Salud e Investigacion-Centro de Osteopatías Médicas | Ciudad Autonoma De Buenos Air, Buenos Aires, C1128AAF, Argentina Active, not recruiting
CER Instituto Medico | Quilmes, Buenos Aires, B1878DVC, Argentina Active, not recruiting
Instituto de Investigaciones Clinicas Quilmes | Quilmes, Buenos Aires, B1878GEG, Argentina Completed
Fundación de Estudios Clínicos | Rosario, Santa Fe, S2000DEJ, Argentina Active, not recruiting
Sanatorio 9 de Julio SA | San Miguel de Tucuman, Tucuman, 4000, Argentina Active, not recruiting
Centro Medico Privado de Reumatologia | SAN M. DE Tucuman, Tucumán, T4000AXL, Argentina Active, not recruiting
Hospital Privado Centro Medico de Cordoba SA | Cordoba, X5016KEH, Argentina Active, not recruiting
John Hunter Hospital | Newcastle, New South Wales, 2305, Australia Completed
Princess Alexandra Hospital | Brisbane, Queensland, 4102, Australia Active, not recruiting
Coastal Digestive Health | Maroochydore, Queensland, 4558, Australia Active, not recruiting
Mater University Hospital | South Brisbane, Queensland, 4101, Australia Completed
Royal Adelaide Hospital | Adelaide, South Australia, 5000, Australia Active, not recruiting
Box Hill Hospital | Box Hill, Victoria, 3128, Australia Active, not recruiting
The Northern Hospital | Epping, Victoria, 3076, Australia Completed
Melbourne Gastrointestinal Investigation Unit (MGIU) | Malvern, Victoria, 3144, Australia Completed
The Alfred Hospital | Melbourne, Victoria, 3004, Australia Active, not recruiting
The Royal Melbourne Hospital | Parkville, Victoria, 3050, Australia Active, not recruiting
Medizinische Universität Innsbruck | Innsbruck, 6020, Austria Active, not recruiting
Universitätsklinikum Salzburg | Salzburg, 5020, Austria Active, not recruiting
Medical University of Vienna | Vienna, 1090, Austria Active, not recruiting
Krankenhaus der Barmherzigen Schwestern | Wien, 1060, Austria Completed
Universitair Ziekenhuis Gent | Gent, Oost-Vlaanderen, 9000, Belgium Active, not recruiting
AZ Klina | Brasschaat, 2930, Belgium Active, not recruiting
AZ Groeninge | Kortrijk, 8500, Belgium Completed
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven, 3000, Belgium Active, not recruiting
Centre Hospitalier de Wallonie picarde - CHwapi A.S.B.L. | Tournai, 7500, Belgium Active, not recruiting
Allen Whey Khye Lim Professional Corporation | Edmonton, Alberta, T5R 1W2, Canada Active, not recruiting
The Gordon and Leslie Diamond Health Care Centre | Vancouver, British Columbia, V5Z 1M9, Canada Active, not recruiting
GI Research Institute | Vancouver, British Columbia, V6Z 2K5, Canada Active, not recruiting
PerCuro Clinical Research Ltd. | Victoria, British Columbia, V8V 3M9, Canada Active, not recruiting
Victoria Hospital | London, Ontario, N6A 4G5, Canada Active, not recruiting
University of Western Ontario | London, Ontario, N6A 5G1, Canada Active, not recruiting
Centre de santé et de services sociaux Champlain-Charles-Le Moyne | Greenfield Park, Quebec, J4V 2H1, Canada Active, not recruiting
Hopital Maisonneure-Rosemount | Montreal, Quebec, H1T 2M4, Canada Active, not recruiting
Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC | Montreal, Quebec, H3G 1A4, Canada Active, not recruiting
Anhui Provincial Hospital | Hefei City, Anhui, 230000, China Recruiting 13855170097 Kaiguang Zhang Principal Investigator
The First Affiliated Hospital of Anhui Medical University | HefeiCity, Anhui, 230022, China Recruiting 13956047040 Naizhong Hu Principal Investigator
Beijing Friendship Hospital | Beijing, Beijing, 100050, China Recruiting 13910702345 Yongdong Wu Principal Investigator
Xiangya Hospital Central South University | Kaifu District, Changsha City, 410008, China Recruiting 13787270539 Meihua Xu Principal Investigator
The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA | Chongqing, Chongqing, 400037, China Recruiting 8613508389768 Hong Guo Principal Investigator
The First Hospital Affiliated to AMU (Southwest Hospital) | Chongqing, Chongqing, 400038, China Recruiting 13508389768 Lei Chen Principal Investigator
Fujian Province Hospital | Fuzhou, Fujian, 350001, China Recruiting 13799371368 Zhihui Lin Principal Investigator
The Sixth Affiliated Hospital, Sun Yat-Sen University | Guangzhou, Guangdong, 510655, China Recruiting 863502405878 Xiang Gao Principal Investigator
The University of Hong Kong-Shenzhen Hospital | Shenzhen, Guangdong, 518053, China Recruiting 8675583913333 Wai Kay Walter Seto Principal Investigator
Hainan General Hospital | Haikou, Hainan, 570311, China Recruiting 13086008873 Hong Wei Principal Investigator
Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan, Hubei, 430022, China Recruiting 13035143646 Xiaohua Hou Principal Investigator
The Affiliated Drum Tower Hospital of Nanjing University | Nanjing, Jiangsu, 210008, China Recruiting 13770771661 Xiaoping Zou Principal Investigator
Jiangsu Province Hospital of Chinese Medicine | Nanjing, Jiangsu, 210029, China Recruiting 138 5187 2859 Hong Shen Principal Investigator
Jiangsu Province Hospital | Nanjing, Jiangsu, 210029, China Recruiting 13951913128 Guoxin Zhang Principal Investigator
Zhongda Hospital Southeast University | Nanjing, Jiangsu, 210029, China Recruiting 13951799326 Ruihua Shi Principal Investigator
Nanjing Medical University - Nanjing Jiangning Hospital | Nanjing, Jiangsu, 211106, China Recruiting 862552281322 Jianning Wang Principal Investigator
Jiangxi Pingxiang People's Hospital | Pingxiang, Jiangxi, 337055, China Recruiting 13979936681 Xing Li Principal Investigator
Jilin Central General Hospital | Jilin, Jilin, 132011, China Recruiting 8615543430315 Dongming Wang Principal Investigator
The Second Hospital of Dalian Medical University | Dalian, Lianing, 116000, China Recruiting 13940891419 Chunmeng Jiang Principal Investigator
Qilu Hospital of Shandong University | Jinan, Shandong, 250014, China Recruiting 18560087666 Yanqing Li Principal Investigator
Liaocheng People's hospital | Liaocheng, Shandong, 252000, China Recruiting 8613346256157 Peng Yan Principal Investigator
Ruijin Hospital Shanghai Jiaotong University School of Medicine | Shanghai, Shanghai, 200025, China Recruiting 8613817815616 Jie Zheng Principal Investigator
Renji Hospital Affliated to Shanghai Jiaotong University | Shanghai, Shanghai, 200127, China Recruiting 13801868827 Zhihua Ran Principal Investigator
West China Hospital Sichuan University | Chengdu, Sichuan, 610041, China Recruiting 8618980601283 Yufang WANG Principal Investigator
No.1 Hospital Affiliated to Xinjiang Medical University | Urumchi, Urumchi, 830054, China Recruiting 15999101990 Ping Yao Principal Investigator
Kunming Medical College Affiliated First Hospital | Kunming, Yunnan, 650032, China Recruiting 13708498467 Yinglei Miao Principal Investigator
The First People's Hospital of Yunnan Province | Kunming, Yunnan, 650034, China Recruiting 13678786157 Zhengji Song Principal Investigator
The Second Affiliated Hospital of Zhejiang University School of Med | Hangzhou, Zhejiang, 310000, China Recruiting 13757118653 Yan Chen Principal Investigator
First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou, Zhejiang, 310003, China Recruiting 8613906523922 Chunxiao Chen Principal Investigator
Sir Run Run Shaw Hospital | Hangzhou, Zhejiang, 310016, China Recruiting 13588706896 Qian Cao Principal Investigator
The Second Affiliated Hospital of Wenzhou Medical College | Wenzhou, Zhejiang, 325027, China Recruiting 8613676715542 Yi Jiang Principal Investigator
Tongji Hospital of Tongji University | Wuhan, 430030, China Recruiting 13971107769 Dean Tian Principal Investigator
University Hospital Center Osijek | Osijek, 31000, Croatia Completed
CHC Zagreb | Zagreb, 10000, Croatia Completed
Polyclinic Bonifarm | Zagreb, 10000, Croatia Completed
Fakultni nemocnice Kralovske Vinohrady | Praha 10, Hl. M. Praha, 100 34, Czechia Active, not recruiting
Klinika ResTrial | Praha, Modrany, 14300, Czechia Completed
Vojenska nemocnice Brno | Brno, 636 00, Czechia Active, not recruiting
Fakultni nemocnice u sv. Anny v Brne | Brno, 65691, Czechia Active, not recruiting
Hepato-gastroenterologie HK, s.r.o. | Hradec Kralove, 50012, Czechia Active, not recruiting
Gregar s.r.o. | Olomouc, 779 00, Czechia Active, not recruiting
PreventaMed, s.r.o. | Olomouc, 779 00, Czechia Active, not recruiting
A-Shine s.r.o. | Plzen, 31200, Czechia Active, not recruiting
Mediendo s.r.o. | Praha 8 - Karlin, 18600, Czechia Active, not recruiting
ISCARE Clinical Centre | Praha 9, 19000, Czechia Active, not recruiting
Sydvestjysk Sygehus Esbjerg | Esbjerg, 6700, Denmark Completed
Herlev and Gentofte Hospital | Herlev, 2730, Denmark Active, not recruiting
Zealand University Hospital Køge | Køge, 4600, Denmark Active, not recruiting
Hopital de Hautepierre - Service d'Hépatogastroentérolgie | Strasbourg Cedex, Bas Rhin, 67098, France Active, not recruiting
Hopital Saint-Louis | Paris, Cedex 10, 75475, France Active, not recruiting
CHU Lille - Hôpital Claude Huriez | Lille cedex, Nord, 59037, France Active, not recruiting
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud - | Pierre Benite cedex, Rhone, 69495, France Active, not recruiting
CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro | Amiens Cedex, Somme, 80480, France Active, not recruiting
CHU Tours - Hôpital Trousseau | Chambray les Tours, 37170, France Active, not recruiting
Hopital Beaujon | Clichy, 92110, France Active, not recruiting
Hopital Nord de Marseille | Marseille Cedex 20, 13915, France Active, not recruiting
Hopital Saint Eloi | Montpellier, 34295, France Active, not recruiting
Hopital L'Archet 2 | Nice Cedex, 06200, France Active, not recruiting
Centre Hospitalier de Pau | Pau CEDEX, 64000, France Active, not recruiting
CHU Bordeaux - Hôpital Haut-Lévêque | Pessac Cedex, 33604, France Active, not recruiting
CHU de Poitiers- Service d'Hépato-gastro-entérologie, | Poitiers Cedex, 86021, France Completed
Robert Debre Hospital | Reims, 51092, France Active, not recruiting
CHU de Saint Etienne Hopital Nord | Saint Priest en Jarez, 42270, France Active, not recruiting
CHRU Nancy Brabois - Hôpital d'Enfants | Vandoeuvre les Nancy, 54500, France Active, not recruiting
Staedisches Klinikum Brandenburg | Brandenburg an der Havel, Brandenburg, 14770, Germany Active, not recruiting
Medizinische Hochschule Hanover | Hannover, Niedersachsen, 30625, Germany Active, not recruiting
Gastro Campus Research GbR | Muenster, Nordrhein Westfalen, 48159, Germany Completed
Studiengesellschaft BSF Unternehmergesellschaft haftungsbeschraenkt | Halle (Saale),, Sachsen Anhalt, 06108, Germany Active, not recruiting
Martin-Luther-Universität Halle-Wittenberg | Halle (Saale), Sachsen-Anhalt, 06120, Germany Active, not recruiting
Charité Universitätsmedizin Berlin Campus Buch | Berlin, 10117, Germany Active, not recruiting
Charité Universitätsmedizin Berlin Campus Buch | Berlin, 12203, Germany Active, not recruiting
Krankenhaus Waldfriede e. V. | Berlin, 14163, Germany Active, not recruiting
Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen | Hamburg, 20251, Germany Active, not recruiting
INLUGA im Haus der Gesundheit | Ludwigshafen, 67067, Germany Active, not recruiting
Praxiszentrum Alte Maelzerei | Regensburg, 93053, Germany Completed
Internistische Praxisgemeinschaft | Weyhe, 28844, Germany Active, not recruiting
DRC Gyogyszervizsgalo Rendelointezet Kft | Balatonfüred, EU, 8230, Hungary Active, not recruiting
Obudai Egeszsegugyi Centrum Kft | Budapest, 1036, Hungary Active, not recruiting
Magyar Honvedseg Egeszsegugyi Kozpont | Budapest, 1062, Hungary Active, not recruiting
Semmelweis Egyetem | Budapest, 1088, Hungary Active, not recruiting
Debreceni Egyetem Klinikai Kozpont | Debrecen, 4032, Hungary Active, not recruiting
Endomedix Diagnosztikai Kozpont | Miskolc, 3525, Hungary Active, not recruiting
Karolina Korhaz-Rendelointezet | Mosonmagyarovar, 9200, Hungary Active, not recruiting
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika | Szeged, 6720, Hungary Active, not recruiting
Clinfan Szolgaltato Kft. | Szekszard, 7100, Hungary Active, not recruiting
Javorszky Odon Hospital | Vac, 2600, Hungary Active, not recruiting
Osmania Medical College & Hospital | Hyderabad, Andhra Pradesh, 500012, India Active, not recruiting
Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre | Hyderabad, Andhra Pradesh, 500058, India Active, not recruiting
Yashoda Hospital | Secunderabad, Andhra Pradesh, 500003, India Active, not recruiting
Institute of Digestive and Liver Diseases | Guwahati, Assam, 781 006, India Completed
Escorts Heart Institute and Research Centre Ltd | New Delhi, Delhi, 110 025, India Active, not recruiting
Sir Ganga Ram Hospital | New Delhi, Delhi, 110060, India Completed
Apollo Research and Innovations, Apollo Hospitals International Ltd | Gandhinagar, Gujarat, 382428, India Active, not recruiting
Shree Giriraj Hospital | Rajkot, Gujarat, 360005, India Active, not recruiting
Nirmal Hospital Private Limited | Surat, Gujarat, 395002, India Active, not recruiting
Bangalore Medical College and Research Institute | Bangalore, Karnataka, 560 002, India Active, not recruiting
M S Ramaiah Medical College Hospital | Bangalore, Karnataka, 560054, India Active, not recruiting
Lokmanya Hospital | Mumbai, Maharashtra, 400022, India Completed
Fortis Hospital | Mumbai, Maharashtra, 400078, India Active, not recruiting
Poona Medical Foundation. Ruby Hall Clinic | Pune, Maharashtra, 411 001, India Active, not recruiting
K E M Hospital and Research Centre | Pune, Maharashtra, 411011, India Completed
Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital | Wardha, Maharashtra, 442004, India Active, not recruiting
Midas Multispecilaity Hopsital Pvt Ltd | Ramdaspeth, Nagpur, 440010, India Active, not recruiting
Dayanand Medical College | Ludhiana, Punjab, 141001, India Active, not recruiting
S.R. Kalla Hospital | Jaipur, Rajasthan, 302001, India Active, not recruiting
King George Medical University | Lucknow, Uttar Pradesh, 226003, India Active, not recruiting
Fortis Hospital | Noida, Uttar Pradesh, 201301, India Active, not recruiting
SSKM Post Graduate Hospital | Kolkata, West Bengal, 700020, India Completed
Nil Ratan Sircar Medical College | Kolkata, West Bengal, 700073, India Completed
Asian Institute of Gastroenterology | Hyderabad, 500082, India Completed
Gandhi Hospital | Telangana, 500003, India Active, not recruiting
Beaumont Hospital | Dublin, DUBLIN 9, Ireland Active, not recruiting
Shaare Zedek Medical Center | Bait Vagan, Jerusalem, 91031, Israel Active, not recruiting
Soroka Medical Center - Pediatric Outpatient Clinic | Beer-Sheva, 8410101, Israel Active, not recruiting
Meir Medical Center | Kfar Saba, 4428164, Israel Completed
Galilee Medical Center Department of Internal Medicine A | Nahariya, 2210001, Israel Active, not recruiting
Chaim Sheba Medical Center | Ramat Gan, 5262100, Israel Completed
Kaplan Medical Center | Rehovot, 7610001, Israel Active, not recruiting
Tel Aviv Sourasky Medical Center | Tel Aviv, 6423906, Israel Active, not recruiting
Assaf Harofeh Medical Center | Zerifin, 70300, Israel Active, not recruiting
Presidio di Rho | Rho, Milano, 20017, Italy Active, not recruiting
Istituto Clinico Humanitas | Rozzano, Milano, 20089, Italy Active, not recruiting
Ospedale Sandro Pertini | Roma, RM, 00157, Italy Active, not recruiting
Azienda Ospedaliera Universitaria Policlinico Tor Vergata | Torre, Roma, 00133, Italy Active, not recruiting
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) | Brescia, 25123, Italy Active, not recruiting
Azienda ospedaliero-universitaria Mater Domini | Catanzaro, 88100, Italy Active, not recruiting
Azienda Ospedaliera Universitaria Careggi | Firenze, 50134, Italy Completed
Azienda Ospedaliero Universitaria San Martino | Genova, 16132, Italy Active, not recruiting
Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation | Milano, 20122, Italy Active, not recruiting
Azienda Ospedaliera Universitaria Policlinico de Modena | Modena, 41124, Italy Active, not recruiting
Azienda Ospedaliera Universitaria Pisana | Pisa, 56124, Italy Active, not recruiting
Policlinico Univ. Agostino Gemelli | Roma, 00168, Italy Active, not recruiting
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona Medicina Interna | Salerno, 84131, Italy Completed
I.R.C.C.S Policlinico San Donato | San Donato Milanese (MI), 20097, Italy Completed
Ospedale Mauriziano Umberto I | Torino, 10128, Italy Active, not recruiting
Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia | Udine, 33100, Italy Active, not recruiting
Aichi Medical University Hospital | Nagakute-shi, Aichi-ken, 480-1195, Japan Active, not recruiting
Fujita Health University Hospital | Toyoake-shi, Aichi-ken, 470-1192, Japan Active, not recruiting
NHO Hirosaki National Hospital | Hirosaki-shi, Aomori-Ken, 036 8545, Japan Active, not recruiting
Toho University School of Medicine, Sakura Hospital | Sakura, Chiba, 285-8741, Japan Active, not recruiting
Kitakyushu Municipal Medical Center | Kitakyusyu-shi, Fukoka, 802-0077, Japan Active, not recruiting
Fukuoka University Chikushi Hospital | Chikushino-shi, Fukuoka-Ken, 818 8502, Japan Active, not recruiting
Yukinoseibokai St. Mary's Hospital | Kurume-shi, Fukuoka-Ken, 830 8543, Japan Completed
Hidaka Coloproctology Clinic | Kurume-shi, Fukuoka-Ken, 839 0809, Japan Active, not recruiting
Gunma University Hosptial | Maebashi, Gunma, 371-8511, Japan Active, not recruiting
Takasaki General Medical Center | Takasaki, Gunma, 370-0829, Japan Active, not recruiting
NHO Mito Medical Center | Ibaraki-machi, HigaShiibaraki-Gun, 311 3193, Japan Active, not recruiting
Hiroshima University Hospital | Hiroshima-shi, Hiroshima-ken, 734-8551, Japan Active, not recruiting
Asahikawa City Hospital | Asahikawa, Hokkaido, 070-8610, Japan Completed
Tokushukai Sapporo Tokushukai Hospital | Sapporo-shi, Hokkaido, 004 0041, Japan Active, not recruiting
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital | Sapporo-shi, Hokkaido, 060 0033, Japan Completed
Tokushukai Sapporo Higashi Tokushukai Hospital | Sapporo-shi, Hokkaido, 065 0033, Japan Active, not recruiting
Aoyama Clinic GI Endoscopy & IBD Center | Kobe-shi, Hyogo-Ken, 650 0015, Japan Active, not recruiting
Takamatsu Red Cross Hospital | Takamatsu, Kagawa, 760-0017, Japan Completed
Kagawa Prefectural Central Hospital | Takamatsu, Kagawa, 760-8557, Japan Active, not recruiting
Sameshima Hospital | Kagoshima-shi, Kagoshima, 892-0846, Japan Active, not recruiting
Kitasato University Hospital | Sagamihara-shi, Kanagawa-ken, 252-0375, Japan Completed
Sankikai Yokohama Shin midori General Hospital | Yokohama-shi, Kanagawa-Ken, 226 0025, Japan Active, not recruiting
Gokeikai Ofuna Chuo Hospital | Kamakura-shi, Kanagawa, 247-0056, Japan Active, not recruiting
Kawasaki Municipal Kawasaki Hospital | Kawasaki, Kanagawa, 210-0013, Japan Active, not recruiting
Showa University Northern Yokohama Hospital | Yokohama, Kanagawa, 224-8503, Japan Active, not recruiting
Yokohama City University Medical Center | Yokohama, Kanagawa, 232-0024, Japan Active, not recruiting
Kumamoto University Hospital | Kumamoto-shi, Kumamoto, 860-0012, Japan Active, not recruiting
NHO Kyoto Medical Center | Kyoto-shi, Kyoto, 612 8555, Japan Active, not recruiting
Mie University Hospital | Tsu, Mie, 514-8507, Japan Active, not recruiting
Takagi Clinic | Sendai-shi, Miyagi-Ken, 981 3213, Japan Completed
Nagaoka Chuo General Hospital | Nagaoka-shi, Niigata, 940-8653, Japan Active, not recruiting
Ishida Clinic of IBD and Gastroenterology | Oita-shi, Oita-Ken, 870 0823, Japan Active, not recruiting
Shinseikai Sai Gastroenterology, proctology | Fujiidera-shi, Osaka Fu, 583 0027, Japan Active, not recruiting
Kinshukai Infusion Clinic | Osaka-City, Osaka-fu, 530-0011, Japan Active, not recruiting
NHO Osaka National Hospital | Osaka-shi, Osaka, 540 0006, Japan Active, not recruiting
Osaka University Hospital | Suita-shi, Osaka, 565 0871, Japan Completed
Saga-Ken Medical Center Koseikan | Saga-Shi, Saga-Ken, 840-8571, Japan Active, not recruiting
Kumagaya General Hospital | Kumagaya-shi, Saitama-Ken, 360-8567, Japan Active, not recruiting
Tokitokai Tokito Clinic | Saitama-shi, Saitama-Ken, 336 0963, Japan Active, not recruiting
Matsuaikai Matsuda Hospital | Hamamatsu-shi, Shizuoka-Ken, 4328061, Japan Active, not recruiting
Jichi Medical University Hospital | Shimotsuke-shi, Tochigi-Ken, 329-0498, Japan Active, not recruiting
Mitsui Memorial Hospital | Chiyoda-ku, Tokyo-To, 101-8643, Japan Active, not recruiting
Center Hospital of the National Center for Global Health and Medicine | Shinjuku-ku, Tokyo-To, 162 8655, Japan Completed
Juntendo University Hospital | Bunkyo-ku, Tokyo, 113-8431, Japan Completed
Tokyo Medical And Dental University Medical Hospital | Bunkyō, Tokyo, 113-8519, Japan Active, not recruiting
Showa University Koto Toyosu Hospital | Koto-ku, Tokyo, 135 8577, Japan Completed
Kitasato University Kitasato Institute Hospital | Minato-Ku, Tokyo, 108 8642, Japan Active, not recruiting
Kyorin University Hospital | Mitaka, Tokyo, 181-8611, Japan Active, not recruiting
JHCO Tokyo Yamate Medical Center | Shinjuku-ku, Tokyo, 169-0073, Japan Active, not recruiting
Toyama Prefectural Central Hospital | Toyama-Shi, Toyama, 930-8550, Japan Active, not recruiting
Fukuoka University Hospital | Fukuoka, 814-0180, Japan Active, not recruiting
Okayama University Hospital | Okayama, 700-8558, Japan Active, not recruiting
The Catholic University of Daejeon St. Mary's Hospital | Jung-gu, Daejeon, 34943, Korea, Republic of Active, not recruiting
Severance Hospital | Wonju-si, Gangwon-do, 26426, Korea, Republic of Active, not recruiting
Korea University Ansan Hospital | Ansan-si, Gyeonggi-do, 15355, Korea, Republic of Active, not recruiting
The Catholic University of Korea, St. Vincent's Hospital | Suwon-si, Gyeonggi-do, 16247, Korea, Republic of Completed
Ajou University Hospital | Suwon, Gyeonggi-do, 16499, Korea, Republic of Active, not recruiting
Hanyang University Guri Hospital | Guri-si, Gyeonggido, 11923, Korea, Republic of Active, not recruiting
Kyung Hee University Hospital | Seoul, Korea, 02447, Korea, Republic of Active, not recruiting
Asan Medical Center | Seoul, Korea, 05505, Korea, Republic of Active, not recruiting
Dong-A University Hospital | Busan, Pusan-Kwangyǒkshi, 49201, Korea, Republic of Active, not recruiting
Kangbuk Samsung Hospital | Seoul, Seoul-teukbyeolsi [Seoul], 03181, Korea, Republic of Active, not recruiting
Samsung Medical Center | Seoul, Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of Active, not recruiting
Inje University Haeundae Paik Hospital | Busan, 48108, Korea, Republic of Active, not recruiting
Kyungpook National University Medical Center Chilgok Hospital | Daegu, 41404, Korea, Republic of Completed
Yeungnam Univeristy Medical Center | Daegu, 42415, Korea, Republic of Active, not recruiting
Seoul National University Hospital | Seoul, 03080, Korea, Republic of Active, not recruiting
Ewha Womans University Mokdong Hospital | Seoul, 07985, Korea, Republic of Active, not recruiting
Digestive Diseases Center "Gastro" | Riga, 1079, Latvia Active, not recruiting
Pauls Stradins Kliniska Universitates Slimnica | Riga, LV-1002, Latvia Active, not recruiting
Riga Eastern Clinical University Hospital | Riga, LV-1038, Latvia Active, not recruiting
Hospital of Lithuanian University of Health Sciences Kaunas | Kaunas, 50161, Lithuania Active, not recruiting
Republic Hospital of Klaipeda | Klaipeda, 92231, Lithuania Active, not recruiting
Klaipeda Seamen's Hospital | Klaipeda, 92288, Lithuania Active, not recruiting
Respublikine Panevezio Ligonine | Panevezys, LT-35144, Lithuania Active, not recruiting
Vilnius University Hospital Santariskiu Clinics | Vilnius, LT-08661, Lithuania Active, not recruiting
Hospital Sultanah Bahiyah | Alor Star, Kedah, 05460, Malaysia Completed
Pusat Penyelidikan Klinikal (CRC), Hospital Raja Perempuan Zainab II | Kota Bharu, Kelantan, 15586, Malaysia Active, not recruiting
Universiti Sains Malaysia | Kubang Kerian, Kelantan, 16150, Malaysia Active, not recruiting
University Malaya Medical Centre | Lembah Pantai, Kuala Lumpur, 59100, Malaysia Active, not recruiting
Hospital Pulau Pinang | Georgetown, Penang, 10450, Malaysia Completed
Hospital Ampang | Ampang, Selangor, 68000, Malaysia Active, not recruiting
Pusat Perubatan University Kebangsaan Malaysia | Cheras, Kuala Lumpur, 56000, Malaysia Active, not recruiting
Clinicos Asociados BOCM, S.C. | Mexico, DF, 03300, Mexico Completed
Centro de Investigación Clínica Acelerada | Mexico City, Distrito Federal, 07020, Mexico Active, not recruiting
Clinical Research Institute S C | Tlalnepantla, Edo De Mex, 54055, Mexico Completed
Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V. | Zapopan, Jalisco, 45030, Mexico Active, not recruiting
Christus Muguerza Sur S.A. de C.V. | Monterrey, Nuevo León, 64908, Mexico Active, not recruiting
Centro Para el Desarrollo de la Medicina y de Asistencia Med | Culiacan, Sinaloa, 80230, Mexico Active, not recruiting
Clinical Medical Research S.C. | Orizaba, Veracruz, 94300, Mexico Active, not recruiting
Scientia Investigacion Clinica S.C. | Chihuahua, 31203, Mexico Active, not recruiting
Sociedad de Metabolismo y Corazon S.C. | Veracruz, 91900, Mexico Active, not recruiting
St Elisabeth Ziekenhuis | Tilburg, Noord Brabant, 5022 GC, Netherlands Active, not recruiting
Academisch Medisch Centrum | Amsterdam, Noord-Holland, 1105 AZ, Netherlands Active, not recruiting
Amphia Ziekenhuis | Breda, 4818 CK, Netherlands Active, not recruiting
Albert Schweitzer Ziekenhuis | Dordrecht, 3318 AT, Netherlands Active, not recruiting
Bernhoven Ziekenhuis | Uden, 5406 PT, Netherlands Active, not recruiting
UMC Utrecht, Dept. of Internal Medicine, MDL | Utrecht, 3584 CX, Netherlands Active, not recruiting
Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej | Bydgoszcz, Kujawsko-pomorskie, 85-168, Poland Active, not recruiting
Promedica S.C | Bedzin, 42-500, Poland Active, not recruiting
Centrum Medyczne Pratia Bydgoszcz | Bydgoszcz, 85-796, Poland Active, not recruiting
NZOZ ALL-MEDICUS, Zaklad Gastroenterologii | Katowice, 40-660, Poland Active, not recruiting
Indywidualna Specjalistyczna Praktyka Lekarska | Knurow, 44-190, Poland Completed
Topolowa Medicenter | Krakow, 31-506, Poland Active, not recruiting
GASTROMED Zakład Opieki Zdrowotnej | Lublin, 20-582, Poland Active, not recruiting
Samodzielny Publiczny Szpital Kliniczny nr 4 | Lublin, 20-954, Poland Active, not recruiting
Medicenter Nowy Targ | Nowy Targ, 34-400, Poland Active, not recruiting
Wojewodzki Specjalistyczny Szpital w Olsztynie | Olsztyn, 10-561, Poland Active, not recruiting
Endoskopia sp z o. o | Sopot, 81-756, Poland Completed
KO-MED Centra Kliniczne Staszow | Staszow, 28-200, Poland Active, not recruiting
Twoja Przychodnia-Szczecinskie Centrum Medyczne | Szczecin, 71-434, Poland Active, not recruiting
Niepubliczny Zaklad Opieki Zdrowotnej SONOMED | Szczecin, 71-685, Poland Active, not recruiting
Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii | Torun, 87-100, Poland Active, not recruiting
Nzoz Formed | Wadowice, 34-100, Poland Active, not recruiting
Warsaw IBD Point Profesor Kierkus | Warszawa, 00-728, Poland Active, not recruiting
Centrum Zdrowia Matki, Dziecka i Młodzieży (CZMDM) Przychodnie | Warszawa, 00635, Poland Active, not recruiting
Centrum Medyczne NeuroProtect | Warszawa, 01-697, Poland Active, not recruiting
Centralny Szpital Kliniczny MSWiA | Warszawa, 02-507, Poland Completed
Vivamed | Warszawa, 03-580, Poland Active, not recruiting
PlanetMed Sp.z o.o. | Wroclaw, 52-210, Poland Active, not recruiting
LexMedica Osrodek Badan Klinicznych | Wroclaw, 53 114, Poland Active, not recruiting
ETG Zamosc | Zamosc, 22-400, Poland Active, not recruiting
CCBR Clinical Research | Bucharest, București, 030463, Romania Active, not recruiting
MedLife Grivita | Bucuresti, 010719, Romania Active, not recruiting
Spitalul Clinic Colentina | Bucuresti, 020125, Romania Active, not recruiting
Institutul Clinic Fundeni | Bucuresti, 022328, Romania Completed
Institutul Clinic Fundeni | Bucuresti, 022328, Romania Active, not recruiting
Hifu Terramed Conformal SRL | Bucuresti, 031864, Romania Active, not recruiting
Centrul Medical Unirea SRL | Bucuresti, 040055, Romania Completed
Spital Pelican Oradea | Oradea, 410469, Romania Active, not recruiting
Multidisciplinary Medical Clinic "Anthurium" | Barnaul, 656043, Russian Federation Active, not recruiting
Medical and Sanitary Division of Severstal | Cherepovets, 162600, Russian Federation Active, not recruiting
LLC MA New Hospital | Ekaterinburg, 620109, Russian Federation Active, not recruiting
Irkutsk State Medical Academy of Continuing Education | Irkutsk, 664049, Russian Federation Active, not recruiting
LLC Alliance Biomedical - Ural Group | Izhevsk, 426061, Russian Federation Active, not recruiting
Clinical Trials Center of Medical Institute | Kaliningrad, 236035, Russian Federation Active, not recruiting
State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan" | Kazan, 420064, Russian Federation Active, not recruiting
SIH Kemerovo Regional