Исследование по изучению CSL112 у субъектов с острым коронарным синдромом

Название протокола
Клинические исследование Острый коронарный синдром: Apolipoprotein A-I [human] (apoA-I), Плацебо - Реестр клинических исследований
Платное
Нет
Дата начала и окончания КИ
2022-02-06 - 2022-02-06
Спонсоры

Ведущий спонсор: CSL Behring

Источник CSL Behring
Краткое содержание

Это фаза 3, многоцентровая, двойная слепая, рандомизированная, плацебо-контролируемая, параллельная группа. исследование для оценки эффективности и безопасности CSL112 в отношении снижения неблагоприятных сердечно-сосудистых заболеваний. события [MACE - смерть от сердечно-сосудистых заболеваний (ССЗ), инфаркт миокарда (ИМ) и инсульт] у субъектов с острым коронарным синдромом (ОКС) с диагнозом миокард с подъемом сегмента ST инфаркт миокарда (ИМпST) или инфаркт миокарда без подъема сегмента ST (ИМпST), включая те, которым удалось провести чрескожное коронарное вмешательство (ЧКВ) или лечить с медицинской точки зрения.

Общий статус Рекрутинг
Дата начала 2018-03-21
Дата завершения 2023-04-01
Дата первичного завершения 2022-07-01
Фаза Фаза 3
Тип исследования Интервенционный
Первичный результат
Мера Временное ограничение
Время до первого появления любого компонента комбинированного MACE (смерть от сердечно-сосудистых заболеваний, инфаркт миокарда или инсульт) Через 90 дней
Вторичный результат
Мера Временное ограничение
Key secondary outcome: Total number of hospitalizations for coronary, cerebral, or peripheral ischemia Through 90 days
Ключевой вторичный результат: время до первого появления смерти от сердечно-сосудистых заболеваний, инфаркта миокарда или инсульта. Через 180 дней
Ключевой вторичный результат: время до первого появления смерти от сердечно-сосудистых заболеваний, инфаркта миокарда или инсульта. Через 365 дней
Время до наступления смерти от ССЗ Через 90 дней
Время до первого появления ИМ Через 90 дней
Время до первого инсульта Через 90 дней
Время до наступления смерти по любой причине Через 365 дней
Количество субъектов с нежелательными явлениями Через 90 дней
Процент субъектов с нежелательными явлениями Через 90 дней
Количество субъектов с побочными эффектами, связанными с лечением Через 365 дней
Процент субъектов с побочными эффектами, связанными с лечением Через 365 дней
Количество субъектов с серьезными нежелательными явлениями Через 365 дней
Процент субъектов с серьезными нежелательными явлениями Через 365 дней
Количество субъектов со сдвигом в клинических лабораторных оценках от исходного уровня до наихудшего значения после лечения в соответствии с критериями нормального диапазона (нормальный, высокий или низкий) Исходный уровень и 29 дней
Процент субъектов со сдвигом в клинических лабораторных оценках от исходного уровня до наихудшего значения после лечения в соответствии с критериями нормального диапазона (нормальный, высокий или низкий) Исходный уровень и 29 дней
Регистрация 17400
Состояние
  • Острый коронарный синдром
Вмешательство

Тип вмешательства: Biological

Название вмешательства: Apolipoprotein A-I [human] (apoA-I)

Описание: Apolipoprotein A-I [human] (apoA-I) purified from human plasma for intravenous administration

Этикетка Arm Group: CSL112

Другое имя: CSL112

Тип вмешательства: Другой

Название вмешательства: Плацебо

Описание: 25% раствор альбумина, разбавленный до 4,4%

Этикетка Arm Group: Плацебо

Приемлемость

Критерии:

Критерии включения: - Мужчина или женщина моложе 18 лет - Признаки некроза миокарда, соответствующие ИМ I типа (спонтанный). - Нет подозрений на острое повреждение почек - Доказательства многососудистой ишемической болезни сердца - Наличие факторов риска сердечно-сосудистых заболеваний: 1. Сахарный диабет на фармакотерапии ИЛИ. 2. 2 или более из следующего: возраст ≥ 65 лет, перенесенный инфаркт миокарда в анамнезе, периферический артериальное заболевание Критерий исключения: - Постоянная гемодинамическая нестабильность. - Доказательства гепатобилиарной болезни - Доказательства тяжелой хронической болезни почек - Запланируйте плановую операцию по аортокоронарному шунтированию в качестве лечения индекс MI - Известная история аллергии, гиперчувствительности или дефицита сои, арахиса или альбумин

Пол:

Все

Минимальный возраст:

18 лет

Максимальный возраст:

N / A

Здоровые волонтеры:

Нет

Общий Официальный
Фамилия Роль Присоединение
Danielle Duffy, MD Study Director CSL Behring - Sr Global Clinical Program Dir - CV & Metabolism
Общий контакт

Фамилия: Trial Registration Coordinator

Телефон: 610-878-4000

Расположение
Объект: Положение дел: Контакт:
8400896 - Advanced Cardiovascular LLC | Alexander City, Alabama, 35010, United States Recruiting Use Central Contact
8400350 - Cardiology, PC | Birmingham, Alabama, 35211, United States Recruiting Use Central Contact
8400337 - Heart Center Research, LLC | Huntsville, Alabama, 35801, United States Recruiting
8400713 - University of South Alabama College of Medicine | Mobile, Alabama, 36617, United States Active, not recruiting
8400556 - Mercy Gilbert Medical Center | Gilbert, Arizona, 85297, United States Recruiting Use Central Contact
8400747 - Phoenix V.A. Health Care System | Phoenix, Arizona, 85012, United States Completed
8400772 - Mayo Clinic Arizona | Phoenix, Arizona, 85054, United States Active, not recruiting
8400996 - Southern Arizona V.A. Healthcare System | Tucson, Arizona, 85723, United States Recruiting Use Central Contact
8400789 - Sparks Regional Medical Center | Fort Smith, Arkansas, 72901, United States Active, not recruiting
8400645 - NEA Baptist Clinic | Jonesboro, Arkansas, 72401, United States Recruiting Use Central Contact
8400975 - Central Arkansas Veterans Healthcare System | Little Rock, Arkansas, 72205, United States Recruiting Use Central Contact
8401054 - Central Cardiology Medical Center | Bakersfield, California, 93308, United States Active, not recruiting
8400379 - John Muir Health and Cardiovascular Institute | Concord, California, 94520, United States Recruiting Use Central Contact
8400931 - Valley Clinical Trials | Covina, California, 91723, United States Recruiting Use Central Contact
8401103 - Orange Coast Memorial Hospital | Fountain Valley, California, 92708, United States Recruiting Use Central Contact
8401166 - Sharp Grossmont Hospital | La Mesa, California, 91942, United States Recruiting Use Central Contact
8401192 - South Orange County Surgical Medical Group | Laguna Hills, California, 92653, United States Recruiting Use Central Contact
8400596 - Long Beach Memorial Medical Center | Long Beach, California, 90806, United States Recruiting Use Central Contact
8400910 - Cardiovascular Innovation and Research Center | Long Beach, California, 90813, United States Active, not recruiting
8400597 - Los Alamitos Cardiovascular | Los Alamitos, California, 90720, United States Recruiting Use Central Contact
8400693 - University of California Los Angeles | Los Angeles, California, 90038, United States Recruiting Use Central Contact
8400717 - V.A. Greater Los Angeles Healthcare System | Los Angeles, California, 90073, United States Recruiting Use Central Contact
8400888 - Saint Jude Heritage Healthcare | Mission Viejo, California, 92691, United States Recruiting Use Central Contact
8400745 - Hoag Memorial Hospital Presbyterian | Newport Beach, California, 92663, United States Recruiting Use Central Contact
8400658 - Valley Clinical Trials, Inc. | Northridge, California, 91325, United States Recruiting Use Central Contact
8400720 - Valley Clinical Trials | Pasadena, California, 91105, United States Recruiting Use Central Contact
8400787 - Riverside Community Hospital | Riverside, California, 92501, United States Active, not recruiting
8400694 - University of California San Diego Medical Center | San Diego, California, 92103, United States Active, not recruiting
8400703 - San Diego Cardiac Center | San Diego, California, 92123, United States Recruiting Use Central Contact
8400719 - V.A. San Diego Health Care System | San Diego, California, 92161, United States Recruiting Use Central Contact
8400909 - Ventura Clinical Trials | Ventura, California, 93003, United States Recruiting Use Central Contact
8400891 - John Muir Medical Center Walnu | Walnut Creek, California, 94598, United States Recruiting Use Central Contact
8400893 - Interventional Cardiology Medical Group | West Hills, California, 91307, United States Recruiting Use Central Contact
8400574 - Aurora Denver Cardiology Associates | Aurora, Colorado, 80012, United States Recruiting Use Central Contact
8400684 - UCHealth Memorial Hospital Central - Colorado Springs | Colorado Springs, Colorado, 80909, United States Completed
8400997 - CardioVascular Institute of North Colorado Cardiology Clinic | Greeley, Colorado, 80631, United States Recruiting Use Central Contact
8400670 - Medical Center of the Rockies | Loveland, Colorado, 80538, United States Completed
8400371 - Danbury Hospital | Danbury, Connecticut, 06810, United States Recruiting Use Central Contact
8401134 - Christiana Hospital | Newark, Delaware, 19718, United States Recruiting Use Central Contact
8400779 - MedStar Clinical Research Center | Washington, District of Columbia, 20010, United States Recruiting Use Central Contact
8400688 - George Washington University Medical Center | Washington, District of Columbia, 20037, United States Recruiting Use Central Contact
8400484 - Clearwater Cardiovascular and Interventional Consultants | Clearwater, Florida, 33756, United States Recruiting Use Central Contact
8400544 - Cardiology Research Associates | Daytona Beach, Florida, 32117, United States Recruiting Use Central Contact
8400930 - Lake Internal Medicine Assoc. | Eustis, Florida, 32726, United States Completed
8400613 - Jim Moran Heart and Vascular Center | Fort Lauderdale, Florida, 33308, United States Recruiting Use Central Contact
8401010 - Integrative Research Associates Inc. | Fort Lauderdale, Florida, 33312, United States Recruiting Use Central Contact
8400490 - University of Florida | Gainesville, Florida, 32610, United States Recruiting Use Central Contact
8400517 - Shands Jacksonville Medical Center | Jacksonville, Florida, 32209, United States Recruiting Use Central Contact
8400985 - Optimus U Corp. | Miami, Florida, 33125, United States Completed
8400543 - Cardiology Partners Research Institute | Palm Beach Gardens, Florida, 33410, United States Recruiting Use Central Contact
8400542 - Cardiology Consultants | Pensacola, Florida, 32501, United States Recruiting Use Central Contact
8400557 - Clearwater Cardiovascular and Interventional Consultants | Safety Harbor, Florida, 34695, United States Recruiting Use Central Contact
8400686 - Intercoastal Medical Group | Sarasota, Florida, 34239, United States Recruiting Use Central Contact
8400736 - Pepin Heart Institute | Tampa, Florida, 33613, United States Recruiting Use Central Contact
8401011 - Cardiology Partners Research Institute | Wellington, Florida, 33449, United States Completed
8401185 - Piedmont Heart Institute | Athens, Georgia, 30606, United States Active, not recruiting
8400376 - Emory University | Atlanta, Georgia, 30322-1059, United States Recruiting Use Central Contact
8400918 - Augusta University | Augusta, Georgia, 30912, United States Recruiting Use Central Contact
8400849 - IACT Health | Columbus, Georgia, 31904, United States Recruiting Use Central Contact
8400655 - Atlanta V.A. Medical Center | Decatur, Georgia, 30033, United States Recruiting Use Central Contact
8401120 - Northeast Georgia Medical Center | Gainesville, Georgia, 30501, United States Recruiting Use Central Contact
8401157 - Memorial Health University Medical Center | Savannah, Georgia, 31404, United States Recruiting Use Central Contact
8400357 - Saint Luke's Boise Medical Center | Boise, Idaho, 83712, United States Recruiting Use Central Contact
8400610 - Jesse Brown V.A. Medical Center | Chicago, Illinois, 60612, United States Recruiting Use Central Contact
8401093 - Advanced Heart Care Group | Fairview Heights, Illinois, 62208, United States Recruiting Use Central Contact
8401000 - Advocate Lutheran General Hospital | Park Ridge, Illinois, 60068, United States Recruiting Use Central Contact
8400785 - OSF Multi-Specialty Group | Peoria, Illinois, 61614, United States Recruiting Use Central Contact
8400361 - Midwest Cardiovascular Research | Elkhart, Indiana, 46514, United States Recruiting Use Central Contact
8400961 - Indiana Heart Physicians, Inc. | Indianapolis, Indiana, 46237, United States Recruiting Use Central Contact
8400989 - Indiana Heart Hospital | Indianapolis, Indiana, 46250, United States Recruiting Use Central Contact
8400507 - The Saint Vincent Heart Center of Indiana | Indianapolis, Indiana, 46290, United States Recruiting Use Central Contact
8400576 - IU Health Ball Memorial Hospital Physicians, Inc | Muncie, Indiana, 47303, United States Recruiting Use Central Contact
8400882 - Reid Health | Richmond, Indiana, 47374, United States Recruiting Use Central Contact
8400618 - McFarland Clinic, PC | Ames, Iowa, 50010, United States Completed
8400904 - Northeast Iowa Medical Education Foundation | Waterloo, Iowa, 50702, United States Recruiting Use Central Contact
8400678 - The Iowa Clinic, PC | West Des Moines, Iowa, 50266, United States Completed
8400978 - Midwest Heart and Vascular | Overland Park, Kansas, 66209, United States Completed
8400661 - Norton Cardiovascular Associates | Louisville, Kentucky, 40205, United States Recruiting Use Central Contact
8400368 - Cambridge Medical Trials | Alexandria, Louisiana, 71301, United States Recruiting Use Central Contact
8400862 - Cardiovascular Associates Research | Covington, Louisiana, 70433, United States Recruiting Use Central Contact
8401104 - Cardiovascular Institute of the South | Houma, Louisiana, 70361-4176, United States Recruiting Use Central Contact
8400563 - Cardiovascular Institute of the South | Lafayette, Louisiana, 70503, United States Recruiting Use Central Contact
8401127 - Tulane University Health Science Center | New Orleans, Louisiana, 70112, United States Recruiting Use Central Contact
8401173 - Ochsner Clinic Foundation | New Orleans, Louisiana, 70121, United States Recruiting Use Central Contact
8401175 - Overton Brooks V.A. Medical Center | Shreveport, Louisiana, 71101, United States Active, not recruiting
8400483 - Eastern Maine Medical Center | Bangor, Maine, 04401, United States Recruiting Use Central Contact
8400812 - Maine Medical Center Bramhall Campus | Portland, Maine, 04102, United States Recruiting Use Central Contact
8401142 - Anne Arundel Health System | Annapolis, Maryland, 21401, United States Completed
8401163 - Washington Adventist Hospital | Takoma Park, Maryland, 20912, United States Recruiting Use Central Contact
8400998 - Beth Israel Deaconess Medical Center | Boston, Massachusetts, 02215, United States Recruiting Use Central Contact
8400769 - Healthy Heart Cardiology | Grandville, Michigan, 49418, United States Recruiting Use Central Contact
8401141 - Western Michigan University Homer Striker MD School of Medicine | Kalamazoo, Michigan, 49048, United States Recruiting Use Central Contact
8400638 - Mid Michigan Regional Medical Center | Midland, Michigan, 48670, United States Recruiting Use Central Contact
8401092 - Saint Joseph Mercy Oakland | Pontiac, Michigan, 48341, United States Recruiting Use Central Contact
8400861 - Ascension Providence Rochester Hospital | Rochester, Michigan, 48307, United States Recruiting Use Central Contact
8400372 - Covenant Medical Center | Saginaw, Michigan, 48602, United States Recruiting Use Central Contact
8400667 - Michigan Cardiovascular Institute | Saginaw, Michigan, 48602, United States Completed
8401165 - Ascension Macomb-Oakland Hospital Warren Campus | Warren, Michigan, 48236, United States Recruiting Use Central Contact
8400625 - Michigan Heart and Vascular Institute | Ypsilanti, Michigan, 48197, United States Recruiting Use Central Contact
8400488 - Essentia Health | Duluth, Minnesota, 55805, United States Completed
8400920 - Saint Lukes Hospital | Duluth, Minnesota, 55805, United States Recruiting Use Central Contact
8400364 - Minneapolis Heart Institute Foundation | Minneapolis, Minnesota, 55401, United States Recruiting Use Central Contact
8400752 - Regions Hospital | Saint Paul, Minnesota, 55101, United States Recruiting Use Central Contact
8400369 - HealthEast Saint Joseph's Hospital | Saint Paul, Minnesota, 55102, United States Completed
8401168 - Jackson Heart Clinic | Jackson, Mississippi, 39216, United States Recruiting Use Central Contact
8400334 - Cardiology Associates of North Mississippi | Tupelo, Mississippi, 38801, United States Recruiting Use Central Contact
8401108 - University of Missouri Health System | Columbia, Missouri, 65212, United States Recruiting Use Central Contact
8400648 - Saint Luke's Cardiovascular Consultants | Kansas City, Missouri, 64111, United States Completed
8400631 - North Kansas City Hospital | North Kansas City, Missouri, 64116, United States Recruiting Use Central Contact
8400840 - Washington University | Saint Louis, Missouri, 63110, United States Recruiting Use Central Contact
8400622 - Mercy Medical Research Institute | Springfield, Missouri, 65807, United States Active, not recruiting
8400091 - Glacier View Cardiology | Kalispell, Montana, 59901, United States Recruiting Use Central Contact
8400783 - Nebraska Heart Institute | Lincoln, Nebraska, 68526, United States Recruiting Use Central Contact
8400689 - University Medical Center | Las Vegas, Nevada, 89102, United States Recruiting Use Central Contact
8400545 - Advanced Heart Care LLC | Bridgewater, New Jersey, 08807, United States Recruiting Use Central Contact
8400835 - Cooper University Hospital | Camden, New Jersey, 08103, United States Recruiting Use Central Contact
8400836 - Our Lady of Lourdes Medical Center | Camden, New Jersey, 08103, United States Recruiting Use Central Contact
8401178 - Jersey Shore University Medical Center Meridian Health | Neptune, New Jersey, 07753, United States Recruiting Use Central Contact
8401144 - Saint Michael's Medical Center | Newark, New Jersey, 07102, United States Recruiting Use Central Contact
8400572 - AtlantiCare Regional Medical Center | Pomona, New Jersey, 08240, United States Recruiting Use Central Contact
8401189 - Cardiovascular Associates of the Delaware Valley | Vineland, New Jersey, 08360, United States Recruiting Use Central Contact
8400742 - VMG Cardiology, Westwood | Westwood, New Jersey, 07675, United States Recruiting Use Central Contact
8400626 - Montefiore Medical Center - Albert Einstein College of Medicine | Bronx, New York, 10461, United States Recruiting Use Central Contact
8400636 - Jacobi Medical Center | Bronx, New York, 10461, United States Recruiting Use Central Contact
8400360 - Buffalo Heart Group | Buffalo, New York, 14215, United States Recruiting Use Central Contact
8401028 - Buffalo V.A. Medical Center | Buffalo, New York, 14215, United States Completed
8400677 - Saint Joseph's Hospital Cardiac Catheterization Associates | Liverpool, New York, 13088, United States Recruiting Use Central Contact
8400380 - Mount Sinai Medical Center | New York, New York, 10029, United States Recruiting Use Central Contact
8401119 - Lenox Hill Hospital | New York, New York, 10075, United States Recruiting Use Central Contact
8401154 - Rochester General Hospital | Rochester, New York, 14621, United States Completed
8400847 - University of Rochester Medical Center-Strong Memorial Hospital | Rochester, New York, 14642, United States Completed
8400726 - Westchester Medical Center | Valhalla, New York, 10595, United States Recruiting Use Central Contact
8401027 - UNC Hospitals Heart and Vascular Center at Meadowmont | Chapel Hill, North Carolina, 27517, United States Recruiting Use Central Contact
8400733 - Novant Health Heart and Vascular Institute | Charlotte, North Carolina, 28204, United States Completed
8400489 - Duke University Hospital | Durham, North Carolina, 27710, United States Active, not recruiting
8400491 - Moses H. Cone Memorial Hospital | Greensboro, North Carolina, 27401-1020, United States Recruiting Use Central Contact
8400366 - High Point Regional Hospital | High Point, North Carolina, 27262, United States Recruiting Use Central Contact
8400916 - Southeastern Cardiology & Cardiovascular Clinic | Lumberton, North Carolina, 28358, United States Recruiting Use Central Contact
8400887 - Matthews Medical Center | Matthews, North Carolina, 28105, United States Completed
8400889 - NC Heart and Vascular Research | Raleigh, North Carolina, 27607, United States Completed
8400322 - Wake Forest University Health Sciences, Dept. of Cardiovascular Medicine | Winston-Salem, North Carolina, 27157, United States Recruiting Use Central Contact
8400651 - Sanford Medical Center Fargo | Fargo, North Dakota, 58122, United States Completed
8400682 - Trinity Medical Group | Minot, North Dakota, 58701, United States Recruiting Use Central Contact
8400657 - Summa Health | Akron, Ohio, 44304, United States Recruiting Use Central Contact
8400793 - Aultman Hospital | Canton, Ohio, 44710, United States Recruiting Use Central Contact
8400858 - University of Cincinnati | Cincinnati, Ohio, 45219, United States Recruiting Use Central Contact
8401233 - Cincinnati V.A. Medical Center | Cincinnati, Ohio, 45220, United States Recruiting Use Central Contact
8400966 - MetroHealth System | Cleveland, Ohio, 44109, United States Recruiting Use Central Contact
8400565 - Miami Valley Hospital | Dayton, Ohio, 45409, United States Recruiting Use Central Contact
8400654 - North Ohio Research Ltd. | Elyria, Ohio, 44035, United States Recruiting Use Central Contact
8400632 - North Ohio Heart Center | Sandusky, Ohio, 44870, United States Recruiting Use Central Contact
8400700 - Mercy Saint Vincent Medical Center | Toledo, Ohio, 43608, United States Recruiting Use Central Contact
8401164 - University of Toledo Medical Center | Toledo, Ohio, 43614, United States Recruiting Use Central Contact
8400639 - Genesis Health Care System | Zanesville, Ohio, 43701, United States Recruiting Use Central Contact
8400504 - Integris Baptist Medical Center | Oklahoma City, Oklahoma, 73112, United States Recruiting Use Central Contact
8400936 - South Oklahoma Heart Research | Oklahoma City, Oklahoma, 73135, United States Recruiting Use Central Contact
8400664 - Oklahoma Heart Institute | Tulsa, Oklahoma, 74104, United States Recruiting Use Central Contact
8401042 - Abington Medical Specialists | Abington, Pennsylvania, 19001, United States Completed
8400595 - Lehigh Valley Hospital | Allentown, Pennsylvania, 18103, United States Completed
8400608 - Holy Spirit Cardiology | Camp Hill, Pennsylvania, 17001, United States Active, not recruiting
8400872 - Chambersburg Hospital | Chambersburg, Pennsylvania, 17201, United States Recruiting Use Central Contact
8400577 - Doylestown Cardiology Associates | Doylestown, Pennsylvania, 18901, United States Active, not recruiting
8400324 - Milton Hershey Medical Center | Hershey, Pennsylvania, 17033, United States Recruiting Use Central Contact
8400344 - Lancaster General Hospital | Lancaster, Pennsylvania, 17604, United States Completed
8400746 - Penn Presbyterian Medical Center | Philadelphia, Pennsylvania, 19104, United States Recruiting Use Central Contact
8400718 - V.A. Pittsburgh Healthcare System | Pittsburgh, Pennsylvania, 15240, United States Recruiting Use Central Contact
8400570 - Advanced Cardiology Specialists | Scranton, Pennsylvania, 18508, United States Recruiting Use Central Contact
8401179 - Reading Hospital | West Reading, Pennsylvania, 19611, United States Completed
8400794 - Geisinger Wyoming Valley | Wilkes-Barre, Pennsylvania, 18711, United States Active, not recruiting
8400811 - Rhode Island Hospital | Providence, Rhode Island, 02903, United States Completed
8400591 - AnMed Health Medical Center | Anderson, South Carolina, 29621, United States Recruiting Use Central Contact
8401171 - Greenville Hospital System | Greenville, South Carolina, 29605, United States Recruiting Use Central Contact
8401055 - Upstate Cardiology, PA | Greenville, South Carolina, 29607, United States Recruiting Use Central Contact
8400496 - Advanced Cardiology Associates | Greenwood, South Carolina, 29646, United States Recruiting Use Central Contact
8400582 - Carolina Heart Specialists | Lancaster, South Carolina, 29720, United States Active, not recruiting
8400320 - Black Hills Cardiovascular Research | Rapid City, South Dakota, 57701, United States Recruiting Use Central Contact
8400854 - The Chattanooga Heart Institute | Chattanooga, Tennessee, 37404, United States Active, not recruiting
8400500 - Tennova Health Care - Turkey Creek Medical Center | Knoxville, Tennessee, 37934, United States Recruiting Use Central Contact
8400760 - V.A. Medical Center - Memphis | Memphis, Tennessee, 38104, United States Recruiting Use Central Contact
8400873 - Baptist Clinical Research Institute | Memphis, Tennessee, 38120, United States Recruiting Use Central Contact
8400801 - Centennial Medical Center | Nashville, Tennessee, 37203, United States Completed
8400735 - Parkway Cardiology Associates, PC | Oak Ridge, Tennessee, 37830, United States Recruiting Use Central Contact
8400551 - Cardiovascular Research of Knoxville | Powell, Tennessee, 37849, United States Recruiting Use Central Contact
8400805 - PharmaTex Research | Amarillo, Texas, 79016, United States Recruiting Use Central Contact
8400482 - Amarillo Heart Clinical Research Institute | Amarillo, Texas, 79106, United States Recruiting Use Central Contact
8400485 - V.A. North Texas Health Care System | Dallas, Texas, 75216, United States Recruiting Use Central Contact
8400911 - Brooke Army Medical Center | Fort Sam Houston, Texas, 78234-6200, United States Active, not recruiting
8401231 - Revival Research Institute | McKinney, Texas, 75069, United States Recruiting Use Central Contact
8400881 - North Texas Research Associates | McKinney, Texas, 75071, United States Completed
8400921 - Mission Research Institute, LLC | New Braunfels, Texas, 78130, United States Recruiting Use Central Contact
8400890 - Revival Research Institute, LLC | Sherman, Texas, 75092, United States Recruiting Use Central Contact
8401176 - Methodist Sugar Land Hospital | Sugar Land, Texas, 77479, United States Active, not recruiting
8401128 - Hillcrest Family Health Center | Waco, Texas, 76710-4023, United States Recruiting Use Central Contact
8400515 - Wichita Falls Heart Clinic | Wichita Falls, Texas, 76301, United States Recruiting Use Central Contact
8401064 - Inova Fairfax Hospital | Falls Church, Virginia, 22042-3300, United States Recruiting Use Central Contact
8400502 - Stroobants Cardiovascular Center | Lynchburg, Virginia, 24501, United States Completed
8400601 - McGuire Research Institute | Richmond, Virginia, 23249, United States Recruiting Use Central Contact
8400759 - Winchester Cardiology and Vascular Medicine | Winchester, Virginia, 22601, United States Recruiting Use Central Contact
8400751 - Providence Everett Medical Center | Everett, Washington, 98201, United States Active, not recruiting
8400628 - Multicare Health System | Puyallup, Washington, 98372, United States Active, not recruiting
8400863 - Swedish Medical Center - Providence Campus | Seattle, Washington, 98122, United States Completed
8400503 - The Heart and Vascular Center / Holy Family Memorial | Manitowoc, Wisconsin, 54220, United States Recruiting Use Central Contact
8400358 - Aspirus Research Institute | Wausau, Wisconsin, 54401, United States Completed
0320069 - Hospital Italiano Regional del Sur | Bahía Blanca, B8001HXM, Argentina Recruiting Use Central Contact
0320020 - Clinica Privada | Buenos Aires, 1722, Argentina Completed
0320025 - Fundación Sanatorio Güemes | Ciudad Autonoma Buenos Aires, 1413, Argentina Recruiting Use Central Contact
0320041 - Clinica y Maternidad Suizo Argentina (CyMSA) | Ciudad Autónoma Buenos Aires, 1118, Argentina Active, not recruiting
0320019 - Hospital Británico de Buenos Aires | Ciudad Autónoma Buenos Aires, 1280, Argentina Recruiting Use Central Contact
0320029 - Instituto Cardiovascular de Buenos Aires | Ciudad Autónoma Buenos Aires, 1428, Argentina Recruiting Use Central Contact
0320034 - Clinica Adventista Belgrano | Ciudad Autónoma Buenos Aires, 1430, Argentina Recruiting Use Central Contact
0320033 - Corporacion Medica de San Martin | Ciudad Autónoma Buenos Aires, 4071, Argentina Recruiting Use Central Contact
0320013 - Hospital Municipal de Coronel Suárez | Coronel Suárez, 7540, Argentina Recruiting Use Central Contact
0320040 - Instituto de Cardiología de Corrientes | Corrientes, 3400, Argentina Recruiting Use Central Contact
0320015 - Clinica Chutro S.R.L. | Córdoba, 5000, Argentina Recruiting Use Central Contact
0320063 - Clinica Romagosa | Córdoba, 5000, Argentina Recruiting Use Central Contact
0320023 - Clínica Privada del Prado | Córdoba, X5000AAX, Argentina Recruiting Use Central Contact
0320012 - Sanatorio Allende | Córdoba, X5000, Argentina Recruiting Use Central Contact
0320036 - Hospital Italiano | Córdoba, X5000, Argentina Recruiting Use Central Contact
0320026 - Clínica Colombo | Córdoba, X5002AOQ, Argentina Recruiting Use Central Contact
0320039 - Santatorio Parque S.A. | Córdoba, X5006IKK, Argentina Recruiting Use Central Contact
0320022 - Hospital El Cruce | Florencio Varela, 1888, Argentina Recruiting Use Central Contact
0320014 - Hospital Italiano La Plata | La Plata, B1897, Argentina Recruiting Use Central Contact
0320016 - Sanatorio Modelo Quilmes | Quilmes, 1878, Argentina Recruiting Use Central Contact
0320044 - Instituto Medico de la Fundacion de Estudios Clínicos | Rosario, 2000, Argentina Recruiting Use Central Contact
0320017 - Entidades Vinculadas al Sanatorio Parque | Rosario, S2000, Argentina Recruiting Use Central Contact
0320071 - Hospital Provincial del Centenario | Rosario, S2000, Argentina Recruiting Use Central Contact
0320070 - Hospital Papa Francisco | Salta, 4400, Argentina Recruiting Use Central Contact
0320073 - Instituto Medico De Alta Complejidad - IMAC | Salta, 4401, Argentina Recruiting Use Central Contact
0320027 - Estudios Clínicos de los Arroyos | San Nicolás, 2900, Argentina Recruiting Use Central Contact
0320021 - Sanatorio Medico de Diagnostico y Tratamiento S.A. | Santa Fe, 3000, Argentina Recruiting Use Central Contact
0320038 - Sanatorio Mayo Privado S.A. | Santa Fe, 3000, Argentina Recruiting Use Central Contact
0320032 - Hospital Dr. Jose Maria Cullen | Santa Fe, S3000, Argentina Recruiting Use Central Contact
0320067 - Sanatorio Santa Rosa | Santa Rosa, P3600, Argentina Recruiting Use Central Contact
0320037 - Centro Privado de Cardiologia (CPC) | Tucuman, 4000, Argentina Recruiting Use Central Contact
0320054 - Clínica Privada de Especialidades Médicas de Villa María | Villa María, 5901, Argentina Recruiting Use Central Contact
0360087 - Campbelltown Hospital | Campbelltown, New South Wales, 2560, Australia Completed
0360069 - Liverpool Hospital | Liverpool, New South Wales, 2170, Australia Recruiting Use Central Contact
0360070 - Royal North Shore Hospital | St. Leonards, New South Wales, 2065, Australia Recruiting Use Central Contact
0360071 - Wollongong Hospital | Wollongong, New South Wales, 2500, Australia Recruiting Use Central Contact
0360063 - Cairns Base Hospital | Cairns, Queensland, 4870, Australia Recruiting Use Central Contact
0360062 - The Prince Charles Hospital | Chermside, Queensland, 4032, Australia Recruiting Use Central Contact
0360061 - Royal Brisbane Hospital | Herston, Queensland, 4029, Australia Recruiting Use Central Contact
0360060 - Gold Coast Hospital | Southport, Queensland, 4215, Australia Recruiting Use Central Contact
0360057 - Royal Adelaide Hospital | Adelaide, South Australia, 5000, Australia Recruiting Use Central Contact
0360032 - Flinders Medical Centre | Bedford Park, South Australia, 5042, Australia Recruiting Use Central Contact
0360055 - Queen Elizabeth Hospital | Woodville South, South Australia, 5011, Australia Recruiting Use Central Contact
0360084 - Royal Hobart Hospital | Hobart, Tazmania, 7001, Australia Recruiting Use Central Contact
0360092 - Monash Medical Centre | Clayton, Victoria, 3168, Australia Recruiting Use Central Contact
0360036 - The Northern Hospital | Epping, Victoria, 3076, Australia Recruiting Use Central Contact
0360096 - Peninsula Health | Frankston, Victoria, 3199, Australia Recruiting Use Central Contact
0360076 - Geelong Hospital | Geelong, Victoria, 3320, Australia Recruiting Use Central Contact
0360081 - Peninsula Heart Centre | Langwarrin, Victoria, 3910, Australia Recruiting Use Central Contact
0360073 - The Alfred Hospital | Melbourne, Victoria, 3004, Australia Recruiting Use Central Contact
0360080 - Fiona Stanley Hospital | Murdoch, Western Australia, 6150, Australia Recruiting Use Central Contact
0360059 - Royal Perth Hospital | Perth, Western Australia, 6000, Australia Recruiting Use Central Contact
0360072 - John Hunter Hospital | New Lambton Heights, 2305, Australia Recruiting Use Central Contact
0400035 - Landeskrankenhaus Feldkirch | Feldkirch, 6800, Austria Recruiting Use Central Contact
0400020 - LKH-Universität Hospital Graz | Graz, 8036, Austria Recruiting Use Central Contact
0400028 - Medizinische Universitaet Innsbruck - Universitaetsklinik für Innere Medizin | Innsbruck, 6020, Austria Recruiting Use Central Contact
0400034 - Klinikum Klagenfurt am Wörthersee | Klagenfurt, 9020, Austria Recruiting Use Central Contact
0400031 - Universitatsklinik fuer Innere Medizin II, Kardiol | Salzburg, 5020, Austria Recruiting Use Central Contact
0400013 - Wilhelminenspital | Wien, 1160, Austria Recruiting Use Central Contact
0560024 - Onze-Lieve-Vrouwziekenhuis VZW (OLV) | Aalst, 9300, Belgium Recruiting Use Central Contact
0560043 - Algemeen Stedelijk Ziekenhuis | Aalst, 9300, Belgium Recruiting Use Central Contact
0560027 - ZNA Middelheim | Antwerpen, 2020, Belgium Recruiting Use Central Contact
0560028 - AZ Klina | Brasschaat, 2930, Belgium Recruiting Use Central Contact
0560020 - AZ Sint-Jan Brugge-Oostende AV | Brugge, 8000, Belgium Recruiting Use Central Contact
0560023 - Centre Hospitalier Universitaire Brugmann | Brussels, 1020, Belgium Recruiting Use Central Contact
0560015 - Clinique Saint Jean | Brussel, 1000, Belgium Completed
0560016 - Ziekenhuis Oost-Limburg | Genk, 3600, Belgium Completed
0560037 - Universitair Ziekenhuis Gent | Gent, 9000, Belgium Recruiting Use Central Contact
0560045 - AZ Sint-Lucas | Gent, 9000, Belgium Recruiting Use Central Contact
0560038 - Jessa Ziekenhuis | Hasselt, 3500, Belgium Active, not recruiting
0560019 - Centre Hospitalier Régional de Huy | Huy, 4500, Belgium Completed
0560026 - Universitair Ziekenhuis Brussel | Jette, 1090, Belgium Recruiting Use Central Contact
0560046 - AZ Groeninge - Campus Kennedylaan | Kortrijk, 8500, Belgium Recruiting Use Central Contact
0560022 - Centre Hospitalier Universitaire de Tivoli | La Louvière, 7100, Belgium Recruiting Use Central Contact
0560036 - Universitair Ziekenhuis Leuven | Leuven, 3000, Belgium Recruiting Use Central Contact
0560017 - CHR de la Citadelle | Liège, 4000, Belgium Recruiting Use Central Contact
0560044 - Heilig Hartziekenhuis Mol | Mol, 2400, Belgium Recruiting Use Central Contact
0560032 - AZ Delta | Roeselare, 8800, Belgium Recruiting Use Central Contact
0560018 - AZ Glorieux | Ronse, 9600, Belgium Recruiting Use Central Contact
0560040 - Campus Saint Elizabeth | Turnhout, 2300, Belgium Recruiting Use Central Contact
0760069 - Hospital Universitario Evangelico de Curitiba | Curitiba, Paraná, 80730-150, Brazil Recruiting Use Central Contact
0760087 - MK BC Pesquisa Clinica | Balneario Camboriu, 88331-085, Brazil Recruiting Use Central Contact
0760056 - Hospital Felício Rocho | Belo Horizonte, 30110-068, Brazil Recruiting Use Central Contact
0760068 - Gutierrez Cardiologia Clinica e Intervencionista Ltda. | Belo Horizonte, 30350-540, Brazil Recruiting Use Central Contact
0760085 - Hospital Universitário São José (HUSJ) | Belo Horizonte, 30860-382, Brazil Recruiting Use Central Contact
0760021 - Fundacao Hospitalar Sao Francisco de Assis | Belo Horizonte, 31110-580, Brazil Recruiting Use Central Contact
0760059 - Hospital do Coração do Brasil | Brasília, 70390-903, Brazil Recruiting Use Central Contact
0760038 - Instituto de Cardiologia do Distrito Federal (ICDF) | Brasília, 70658-700, Brazil Recruiting Use Central Contact
0760057 - Centro de Cardiologia Clinica e Pesquisa Dra. Juliana Souza | Brasília, 70710-100, Brazil Recruiting Use Central Contact
0760060 - Hospital Angelina Caron | Campina Grande Do Sul, 83430-000, Brazil Recruiting Use Central Contact
0760077 - Instituto de Pesquisa Clinica de Campinas | Campinas, 13060-080, Brazil Recruiting Use Central Contact
0760035 - Loema - Instituto de Pesquisa Clinica | Campinas, 13060-400, Brazil Recruiting Use Central Contact
0760034 - Hospital e Maternidade Celso Pierro | Campinas, 13060-904, Brazil Recruiting Use Central Contact
0760061 - Hospital Universitario Maria Aparecida Pedrossian | Campo Grande, 79080-090, Brazil Recruiting Use Central Contact
0760036 - Hospital Geral Universitário de Cuiabá - HGU | Cuiabá, 78025-000, Brazil Recruiting Use Central Contact
0760011 - Hospital Cardiologico Costantini | Curitiba, 80320-320, Brazil Active, not recruiting
0760037 - Hospital de Messejana Dr. Carlos Alberto Gomes Studart | Fortaleza, 60840-285, Brazil Recruiting Use Central Contact
0760009 - Santa Casa de Misericordia de Marilia | Marília, 17515-000, Brazil Recruiting Use Central Contact
0760058 - Hospital São Vicente de Paulo | Passo Fundo, 99010-080, Brazil Recruiting Use Central Contact
0760040 - Santa Casa de Misericordia de Pelotas | Pelotas, 96015-290, Brazil Recruiting Use Central Contact
0760019 - Hospital São Lucas da PUCRS | Porto Alegre, 90610-000, Brazil Recruiting Use Central Contact
0760012 - Instituto de Cardiologia do Rio Grande do Sul | Porto Alegre, 90620-001, Brazil Recruiting Use Central Contact
0760015 - Hospital de Clínicas de Porto | Porto Alegre, 90620-050, Brazil Recruiting Use Central Contact
0760052 - Hospital Nossa Senhora da Conceicao (HNSC) | Porto Alegre, 91350-200, Brazil Recruiting Use Central Contact
0760018 - Pronto Socorro Cardiológico de Pernambuco (PROCAPE) | Recife, 50100-060, Brazil Recruiting Use Central Contact
0760062 - Hospital Agamenon Magalhães | Recife, 52051-380, Brazil Recruiting Use Central Contact
0760075 - Instituto D'Or de Pesquisa e Ensino | Rio De Janeiro, 22281-100, Brazil Recruiting Use Central Contact
0760025 - Hospital Santa Izabel | Salvador, 40050-410, Brazil Recruiting Use Central Contact
0760055 - Instituto Cardio Pulmonar da Bahia - Hospital | Salvador, 40170-130, Brazil Recruiting Use Central Contact
0760053 - Fundação Bahiana de Cardiologia | Salvador, 41810-010, Brazil Recruiting Use Central Contact
0760044 - Hospital da Bahia | Salvador, 41810-011, Brazil Recruiting Use Central Contact
0760041 - Hospital e Maternidade Dr. Christovao da Gama | Santo André, 09030-010, Brazil Recruiting Use Central Contact
0760027 - CEMEC - Centro Multidisciplinar de Estudos Clínicos | São Bernardo Do Campo, 09780-000, Brazil Recruiting Use Central Contact
0760016 - Faculdade de Medicina de Sao Jose do Rio Preto-SP - Hospital | São José Do Rio Preto, 15090-000, Brazil Recruiting Use Central Contact
0760047 - Instituto de Cardiologia de Santa Catarina (ICSC) | São José, 88103-450, Brazil Recruiting Use Central Contact
0760083 - Irmandade da Santa Casa de Misericordia de Sao Paulo | São Paulo, 01221-020, Brazil Recruiting Use Central Contact
0760031 - Instituto do Coração (InCor) | São Paulo, 05403-900, Brazil Recruiting Use Central Contact
0760010 - Eurolatino Medical Research | Uberlândia, 38411-186, Brazil Recruiting Use Central Contact
0760039 - Hospital Evangelico de Vila Velha (HEVV) | Vila Velha, 19460, Brazil Recruiting Use Central Contact
0760081 - Hospital Universitário Cassiano Antonio Moraes (HUCAM) | Vitória, 29060-220, Brazil Active, not recruiting
0760028 - Santa Casa de Votuporanga | Votuporanga, 15500-003, Brazil Recruiting Use Central Contact
1000023 - MHAT "Pulse AD" | Blagoevgrad, 2700, Bulgaria Recruiting Use Central Contact
1000043 - Multiprofile Hospital for Active Treatment Blagoevgrad AD | Blagoevgrad, 2700, Bulgaria Active, not recruiting
1000074 - "UMHAT Deva Mariya" EOOD | Burgas, 8000, Bulgaria Recruiting Use Central Contact
1000072 - Multiprofile Hospital for Active Treatment - Dobrich AD | Dobrich, 9300, Bulgaria Recruiting Use Central Contact
1000029 - Multiprofile Hospital for Active Treatment AD Haskovo | Haskovo, 6300, Bulgaria Recruiting Use Central Contact
1000045 - MHAT City Clinic - Sv. Georgi EOOD | Lom, 3600, Bulgaria Active, not recruiting
1000036 - MHAT-Higia | Pazardzhik, 4400, Bulgaria Active, not recruiting
1000053 - Multiprofile Hospital For Active Treatment - Pazardzhik AD | Pazardzhik, 4400, Bulgaria Active, not recruiting
1000049 - SHATC Sv. Georgi - Pernik | Pernik, 2300, Bulgaria Recruiting Use Central Contact
1000071 - University Multiprofile Hospital for Active Treatment "Dr. G" | Pleven, 5803, Bulgaria Recruiting Use Central Contact
1000057 - Specialized Hospital for Active Treatment in Cardiology EAD | Pleven, 5804, Bulgaria Recruiting Use Central Contact
1000058 - Multiprofile Hospital for Active Treatment Plovdiv AD | Plovdiv, 4003, Bulgaria Recruiting Use Central Contact
1000044 - Second Multiprofile Hospital for Active Treatment - Sofia EA | Sofia, 1202, Bulgaria Recruiting Use Central Contact
1000054 - Multiprofile Hospital for Active Treatment "National Cardiac Hospital" | Sofia, 1309, Bulgaria Recruiting Use Central Contact
1000056 - Acibadem City Clinic Tokuda Hospital, EAD | Sofia, 1407, Bulgaria Recruiting Use Central Contact
1000070 - University Multiprofile Hospital for Active Treatment Alexa | Sofia, 1431, Bulgaria Active, not recruiting
1000033 - University Multiprofile Hospital for Active Treatment | Sofia, 1527, Bulgaria Recruiting Use Central Contact
1000047 - University Hospital for Active Treatment & Emergency Medicine | Sofia, 1606, Bulgaria Recruiting Use Central Contact
1000035 - "MHAT "Sveta Anna"" - Sofia AD | Sofia, 1750, Bulgaria Recruiting Use Central Contact
1000038 - Acibadem City Clinic University Hospital, EOOD | Sofia, 1784, Bulgaria Recruiting Use Central Contact
1000028 - SHAT Cardiology Varna - EAD | Varna, 9002, Bulgaria Recruiting Use Central Contact
1000024 - Multiprofile District Hospital | Veliko Tarnovo, 5000, Bulgaria Recruiting Use Central Contact
1240063 - Heritage Medical Research Clinic | Calgary, Alberta, T2N 4Z6, Canada Recruiting Use Central Contact
1240032 - Royal Alexandra Hospital | Edmonton, Alberta, T5H 3V9, Canada Recruiting Use Central Contact
1240058 - University of Alberta Hospital | Edmonton, Alberta, T6